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91.
Peter Krumbiegel Irina Lehmann Albin Alfreider Gisela J. Fritz David Boeckler Ulrike Rolle-Kampczyk 《Isotopes in environmental and health studies》2013,49(1):75-80
Background.?Studies conducted in Europe as well as in North and South America have tried to link Helicobacter pylori colonization with the drinking water supply, especially since H. pylori is known to survive quite well in water. Methods.?In 2000, a cohort of 1884 grade-two children from two rural counties surrounding the city of Leipzig, Germany (77.4% of the 1991/1992 birth cohort) were tested for H. pylori colonization using the [13C]urea breath test. A parent-completed questionnaire elicited details on living conditions and lifestyle habits including questions on the children's drinking water from sources other than public water supplies, swimming in natural waters, etc. In a second independent study, samples of well water, taken from 157 private wells still used in the two counties, were being tested for the presence of H. pylori, using polymerase chain reaction (PCR) method to determine relevant target DNA fragments of H. pylori. Results.?In county I, 5.7% of the children and in county II 6.6% tested H. pylori-positive. Cluster analyses of the questionnaire data in both counties pointed to ‘drinking water from other than municipal sources’, as the closest H. pylori-associated cluster variable. The cluster estimations were supported by odds ratio (OR) calculations with an OR?=?16.4 (95% confidence interval (CI) 3.1,…,88.5) for county I and OR?=?4.0 (95% CI 1.3,…,12.4) for county II. The PCR analyses showed H. pylori DNA fragments in 10.8% of the wells in county I and 9.2% in county II. The detection limit was set at 10 DNA copies corresponding to 125?bacteria/L, the average infestation of these wells was 931?bacteria/L. Conclusion.?Despite the fact that the microbiological and epidemiological data do not correspond except that both studies were conducted in the same geographical areas, the independent findings of H. pylori in well water in the same general areas where children do seem to drink water other than from the public water supply suggests that water may be an important source of H. pylori infection. 相似文献
92.
Marcus B. Kindervater Katherine M. Marczenko Ulrike Werner‐Zwanziger Saurabh S. Chitnis 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(23):7932-7937
Reaction of a tethered triamine ligand with Bi(NMe2)3 gives a Bi triamide, for which a BiI electronic structure is shown to be most appropriate. The T‐shaped geometry at bismuth provides the first structural model for edge inversion in bismuthines and the only example of a planar geometry for pnictogen triamides. Analogous phosphorus compounds exhibit a distorted pyramidal geometry because of different Bi?N and P?N bond polarities. Although considerable BiI character is indicated for the title Bi triamide, it exhibits reactivity similar to BiIII electrophiles, and expresses either a vacant or a filled p orbital at Bi, as evidenced by coordination of either pyridine N‐oxide or W(CO)5. The product of the former shows evidence of coordination‐induced oxidation state change at bismuth. 相似文献
93.
Burkhard Kleihaus Jutta Kunz Francisco Navarro-Lérida Ulrike Neemann 《General Relativity and Gravitation》2008,40(6):1279-1310
We consider globally regular and black hole solutions in SU(2) Einstein–Yang–Mills–Higgs theory, coupled to a dilaton field.
The basic solutions represent magnetic monopoles, monopole–antimonopole systems or black holes with monopole or dipole hair.
When the globally regular solutions carry additionally electric charge, an angular momentum density results, except in the
simplest spherically symmetric case. We evaluate the global charges of the solutions and their effective action, and analyze
their dependence on the gravitational coupling strength. We show, that in the presence of a dilaton field, the black hole
solutions satisfy a generalized Smarr type mass formula.
B. Kleihaus gratefully acknowledges support by the German Aerospace Center.
F. Navarro-Lérida gratefully acknowledges support by the Ministerio de Educación y Ciencia under grant EX2005-0078. 相似文献
94.
95.
Kavitha Telikepalli Király Tamás Matuschke Jannik Schlotter Ildikó Schmidt-Kraepelin Ulrike 《Mathematical Programming》2022,192(1-2):567-595
Mathematical Programming - Let G be a digraph where every node has preferences over its incoming edges. The preferences of a node extend naturally to preferences over branchings, i.e., directed... 相似文献
96.
Ferrocenyl‐Coupled N‐Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs
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Dr. Julienne K. Muenzner Dr. Bernhard Biersack Alexander Albrecht Tobias Rehm Dr. Ulrike Lacher Dr. Wolfgang Milius Prof. Dr. Angela Casini Dr. Jing‐Jing Zhang Prof. Dr. Ingo Ott Prof. Dr. Viktor Brabec Olga Stuchlikova Dr. Ion C. Andronache Leonard Kaps Prof. Dr. Dr. Detlef Schuppan Prof. Dr. Rainer Schobert 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(52):18953-18962
Four gold(I) carbene complexes featuring 4‐ferrocenyl‐substituted imidazol‐2‐ylidene ligands were investigated for antiproliferative and antivascular properties. They were active against a panel of seven cancer cell lines, including multidrug‐resistant ones, with low micromolar or nanomolar IC50 (72 h) values, according to their lipophilicity and cellular uptake. The delocalized lipophilic cationic complexes 8 and 10 acted by increasing the reactive oxygen species in two ways: through a genuine ferrocene effect and by inhibiting the thioredoxin reductase. Both complexes gave rise to a reorganization of the F‐actin cytoskeleton in endothelial and melanoma cells, associated with a G1 phase cell cycle arrest and a retarded cell migration. They proved antiangiogenic in tube formation assays with endothelial cells and vascular‐disruptive on real blood vessels in the chorioallantoic membrane of chicken eggs. Biscarbene complex 10 was also tolerated well by mice where it led to a volume reduction of xenograft tumors by up to 80 %. 相似文献
97.
M. Sc. Lisa K. Mahnke Dr. Aleksandar Kondinski M. Sc. Ulrike Warzok Prof. Dr. Christian Näther Dr. Jan van Leusen Prof. Dr. Christoph A. Schalley Dr. Kirill Yu. Monakhov Prof. Dr. Paul Kögerler Prof. Dr. Wolfgang Bensch 《Angewandte Chemie (International ed. in English)》2018,57(11):2972-2975
A water‐soluble derivative of the polyoxovanadate {V15E6O42} (E=semimetal) archetype enables the study of cluster shell rearrangements driven by supramolecular interactions. A reaction unique to E=Sb, induced exclusively by ligand metathesis in peripheral [Ni(ethylenediamine)3]2+ counterions, results in the formation of the metastable α1* configurational isomer of the {V14Sb8O42} cluster type. Contrary to all other polyoxovanadate shell architectures, this isomer comprises an inward‐oriented vanadyl group and is ca. 50 and 12 kJ mol?1 higher in energy than the previously isolated α and β isomers, respectively. We discuss this unexpected reaction in light of supramolecular Sb?O???V and Sb?O???Sb contacts manifested in {V14Sb8O42}2 dimers detected in the solid state. ESI MS experiments confirm the stability of these dimers also in solution and in the gas phase. DFT calculations indicate that other, as of yet elusive isomers of {V14Sb8}, might be accessible as well. 相似文献
98.
We show how multistability arises in nonlinear dynamics and discuss the properties of such a behavior. In particular, we show that most attractors are periodic in multistable systems, meaning that chaotic attractors are rare in such systems. After arguing that multistable systems have the general traits expected from a complex system, we pass to control them. Our controlling complexity ideas allow for both the stabilization and destabilization of any one of the coexisting states. The control of complexity differs from the standard control of chaos approach, an approach that makes use of the unstable periodic orbits embedded in an extended chaotic attractor. (c) 1997 American Institute of Physics. 相似文献
99.
Ideas from string theory and quantum field theory have beenthe motivation for new invariants of knots and 3-dimensionalmanifolds which have been constructed from complex algebraicstructures such as Hopf algebras [17, 22], monoidal categorieswith additional structure [24], and modular functors [14, 23].These constructions are closely related. Here we take a unifyingcategorical approach based on a natural 2-dimensional generalisationof a topological field theory in the sense of Atiyah [1], andshow that the axioms defining these complex algebraic structuresare a consequence of the underlying geometry of surfaces. 相似文献
100.
Mugford PF Wagner UG Jiang Y Faber K Kazlauskas RJ 《Angewandte Chemie (International ed. in English)》2008,47(46):8782-8793
One often-cited weakness of biocatalysis is the lack of mirror-image enzymes for the formation of either enantiomer of a product in asymmetric synthesis. Enantiocomplementary enzymes exist as the solution to this problem in nature. These enzyme pairs, which catalyze the same reaction but favor opposite enantiomers, are not mirror-image molecules; however, they contain active sites that are functionally mirror images of one another. To create mirror-image active sites, nature can change the location of the binding site and/or the location of key catalytic groups. In this Minireview, X-ray crystal structures of enantiocomplementary enzymes are surveyed and classified into four groups according to how the mirror-image active sites are formed. 相似文献