Stereospecific palladium-catalyzed 1,4-acetoxychlorination of 1,3-dienes

Palladium-catalyzed oxidation of 1,3-dienes in acetic acid in the presence of LiCl and LiOAc produces 1-acetoxy-4-chloro-2-alkenes in high selectivity. The 1,4-adducts were stereo- and regioselectively functionalized.     

Inside Cover: Bifunctional Dendrimers: From Robust Synthesis and Accelerated One‐Pot Postfunctionalization Strategy to Potential Applications (Angew. Chem. Int. Ed. 12/2009)

By taking advantage of “click” chemistry's chemoselective nature, a new platform of bifunctional AB₂C dendrimers, having acetylene/azide groups anchored within the interior and hydroxy groups on the periphery, has been realized. In their Communication on page 2126 ff. M. Malkoch and co‐workers reveal a simple synthetic route for two sets of frameworks. To illustrate the utility of AB₂C dendrimers they were used in a one‐pot postfunctionalization protocol, in the development of dendritic nanoparticles, and in the formation of hydrogels.