全文获取类型
收费全文 | 1674篇 |
免费 | 68篇 |
国内免费 | 6篇 |
专业分类
化学 | 1385篇 |
晶体学 | 31篇 |
力学 | 13篇 |
数学 | 155篇 |
物理学 | 164篇 |
出版年
2023年 | 22篇 |
2022年 | 29篇 |
2021年 | 40篇 |
2020年 | 40篇 |
2019年 | 28篇 |
2018年 | 30篇 |
2017年 | 26篇 |
2016年 | 53篇 |
2015年 | 65篇 |
2014年 | 75篇 |
2013年 | 96篇 |
2012年 | 108篇 |
2011年 | 106篇 |
2010年 | 62篇 |
2009年 | 61篇 |
2008年 | 99篇 |
2007年 | 106篇 |
2006年 | 91篇 |
2005年 | 82篇 |
2004年 | 59篇 |
2003年 | 49篇 |
2002年 | 59篇 |
2001年 | 16篇 |
2000年 | 31篇 |
1999年 | 19篇 |
1998年 | 22篇 |
1997年 | 15篇 |
1996年 | 11篇 |
1995年 | 20篇 |
1994年 | 14篇 |
1993年 | 12篇 |
1992年 | 12篇 |
1991年 | 13篇 |
1990年 | 10篇 |
1989年 | 15篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 7篇 |
1985年 | 11篇 |
1984年 | 16篇 |
1983年 | 15篇 |
1982年 | 5篇 |
1981年 | 12篇 |
1980年 | 12篇 |
1979年 | 8篇 |
1978年 | 4篇 |
1977年 | 8篇 |
1976年 | 9篇 |
1975年 | 5篇 |
1973年 | 5篇 |
排序方式: 共有1748条查询结果,搜索用时 421 毫秒
971.
Dr. Yen‐Chu Lin Yi Fan Lim Erica Russo Dr. Petra Schneider Lea Bolliger Adriana Edenharter Prof. Dr. Karl‐Heinz Altmann Prof. Dr. Cornelia Halin Dr. Jan A. Hiss Prof. Dr. Gisbert Schneider 《Angewandte Chemie (International ed. in English)》2015,54(35):10370-10374
The computer‐assisted design and optimization of peptides with selective cancer cell killing activity was achieved through merging the features of anticancer peptides, cell‐penetrating peptides, and tumor‐homing peptides. Machine‐learning classifiers identified candidate peptides that possess the predicted properties. Starting from a template amino acid sequence, peptide cytotoxicity against a range of cancer cell lines was systematically optimized while minimizing the effects on primary human endothelial cells. The computer‐generated sequences featured improved cancer‐cell penetration, induced cancer‐cell apoptosis, and were enabled a decrease in the cytotoxic concentration of co‐administered chemotherapeutic agents in vitro. This study demonstrates the potential of multidimensional machine‐learning methods for rapidly obtaining peptides with the desired cellular activities. 相似文献
972.
Cedric J. Gommes Gonzalo Prieto Jovana Zecevic Maja Vanhalle Bart Goderis Krijn P. de Jong Petra E. de Jongh 《Angewandte Chemie (International ed. in English)》2015,54(40):11804-11808
The properties of many functional materials depend critically on the spatial distribution of an active phase within a support. In the case of solid catalysts, controlling the spatial distribution of metal (oxide) nanoparticles at the mesoscopic scale offers new strategies to tune their performance and enhance their lifetimes. However, such advanced control requires suitable characterization methods, which are currently scarce. Here, we show how the background in small‐angle X‐ray scattering patterns can be analyzed to quantitatively access the mesoscale distribution of nanoparticles within supports displaying hierarchical porosity. This is illustrated for copper catalysts supported on meso‐ and microporous silica displaying distinctly different metal distributions. Results derived from X‐ray scattering are in excellent agreement with electron tomography. Our strategy opens unprecedented prospects for understanding the properties and to guide the synthesis of a wide array of functional nanomaterials. 相似文献
973.
Roland Bliem Jessi van der Hoeven Adam Zavodny Oscar Gamba Jiri Pavelec Prof. Petra E. de Jongh Prof. Michael Schmid Prof. Ulrike Diebold Prof. Gareth S. Parkinson 《Angewandte Chemie (International ed. in English)》2015,54(47):13999-14002
Metal–support interactions are frequently invoked to explain the enhanced catalytic activity of metal nanoparticles dispersed over reducible metal oxide supports, yet the atomic‐scale mechanisms are rarely known. In this report, scanning tunneling microscopy was used to study a Pt1‐6/Fe3O4 model catalyst exposed to CO, H2, O2, and mixtures thereof at 550 K. CO extracts lattice oxygen atoms at the cluster perimeter to form CO2, creating large holes in the metal oxide surface. H2 and O2 dissociate on the metal clusters and spill over onto the support. The former creates surface hydroxy groups, which react with the support, ultimately leading to the desorption of water, while oxygen atoms react with Fe from the bulk to create new Fe3O4(001) islands. The presence of the Pt is crucial because it catalyzes reactions that already occur on the bare iron oxide surface, but only at higher temperatures. 相似文献
974.
Dr. Tiago Rodrigues Daniel Reker Dr. Martin Welin Michael Caldera Cyrill Brunner Gisela Gabernet Dr. Petra Schneider Prof. Dr. Björn Walse Prof. Dr. Gisbert Schneider 《Angewandte Chemie (International ed. in English)》2015,54(50):15079-15083
Automated molecular de novo design led to the discovery of an innovative inhibitor of death‐associated protein kinase 3 (DAPK3). An unprecedented crystal structure of the inactive DAPK3 homodimer shows the fragment‐like hit bound to the ATP pocket. Target prediction software based on machine learning models correctly identified additional macromolecular targets of the computationally designed compound and the structurally related marketed drug azosemide. The study validates computational de novo design as a prime method for generating chemical probes and starting points for drug discovery. 相似文献
975.
Effect of Dimethyl Carbonate on the Dynamic Properties and Ionicities of Ionic Liquids with [MIII(hfip)4]− (M=B,Al) Anions
下载免费PDF全文
![点击此处可从《Chemphyschem》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Alexander B. A. Rupp Sabrina Welle Petra Klose Dr. Harald Scherer Prof. Dr. Ingo Krossing 《Chemphyschem》2015,16(9):1940-1947
Several ionic liquids (ILs) comprising [B(hfip)4]? [hfip=OCH(CF3)2] or [Al(hfip)4]? anions and imidazolium or ammonium cations were prepared and mixed with up to 270 mol % of dimethyl carbonate (DMC). The viscosities, conductivities, and self‐diffusion constants of these mixtures and, where possible, of the neat ILs were measured and compared with common [NTf2]? based ILs and their mixtures with DMC. A tremendous decrease of the viscosities and a likewise increase of the conductivities and diffusion constants can be achieved for all classes of ILs. However, the order of the conductivities is partially reversed in the diffusion data. This is probably due to the low dielectric constant of DMC and the, thus, favored ion pairing, as evidenced, for example, by the calculated ionicities. Altogether, our data show that the chemically robust, but high‐melting and more viscous [B(hfip)4]? ILs might be candidates for electrolytes when mixed with suitable molecular solvents. 相似文献
976.
In this contribution, a technique is proposed to create a data‐driven interpretation of a given chemometric analysis of a Raman dataset. In real‐world applications, the chemometric analysis is fixed by some external measurement, for example, a legal standard, or a set of fixed goals. Thus, the exact chemometric work flow is fixed because of those goals. However, a further optimization, for example, of the measurement itself relies on an interpretation of the resulting chemometric analysis. For this purpose, a data‐driven analysis of the chemometric analysis itself has to be carried out. This contribution tries to achieve that goal by combining two methods. The first proposed technique is the calculation of the so‐called importance map, which allows the computation of the importance of every channel for a given model and a given dataset. This importance map is constructed after the complete result of an out‐of‐bag (OOB) validation and the decrease of accuracy by randomized channels. The second technique is the growing of the optimal decision tree based on the action of the model used for chemometric analysis. By this way, a clustering is achieved on which by binary classifiers, the optimal decision tree is grown. This tree can be interpreted as dividing the whole dataset into meta clusters. Combining these techniques, a new way of interpreting datasets based on the chosen model is proposed. This combination closes the gap between chemometric analysis and the need for interpretation. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
977.
Background
The present study used event-related brain potentials to investigate semantic, phonological and syntactic processes in adult German dyslexic and normal readers in a word reading task. Pairs of German words were presented one word at a time. Subjects had to perform a semantic judgment task (house – window; are they semantically related?), a rhyme judgment task (house – mouse; do they rhyme?) and a gender judgment task (das – Haus [the – house]; is the gender correct? [in German, house has a neutral gender: das Haus]).Results
Normal readers responded faster compared to dyslexic readers in all three tasks. Onset latencies of the N400 component were delayed in dyslexic readers in the rhyme judgment and in the gender judgment task, but not in the semantic judgment task. N400 and the anterior negativity peak amplitudes did not differ between the two groups. However, the N400 persisted longer in the dyslexic group in the rhyme judgment and in the semantic judgment tasks.Conclusion
These findings indicate that dyslexics are phonologically impaired (delayed N400 in the rhyme judgment task) but that they also have difficulties in other, non-phonological aspects of reading (longer response times, longer persistence of the N400). Specifically, semantic and syntactic integration seem to require more effort for dyslexic readers and take longer irrespective of the reading task that has to be performed.978.
Allan Greenleaf Yaroslav Kurylev Matti Lassas Gunther Uhlmann 《Communications in Mathematical Physics》2007,275(3):749-789
There has recently been considerable interest in the possibility, both theoretical and practical, of invisibility (or “cloaking”)
from observation by electromagnetic (EM) waves. Here, we prove invisibility with respect to solutions of the Helmholtz and
Maxwell’s equations, for several constructions of cloaking devices. The basic idea, as in the papers [GLU2, GLU3, Le, PSS1],
is to use a singular transformation that pushes isotropic electromagnetic parameters forward into singular, anisotropic ones.
We define the notion of finite energy solutions of the Helmholtz and Maxwell’s equations for such singular electromagnetic
parameters, and study the behavior of the solutions on the entire domain, including the cloaked region and its boundary. We
show that, neglecting dispersion, the construction of [GLU3, PSS1] cloaks passive objects, i.e., those without internal currents,
at all frequencies k. Due to the singularity of the metric, one needs to work with weak solutions. Analyzing the behavior of such solutions inside
the cloaked region, we show that, depending on the chosen construction, there appear new “hidden” boundary conditions at the
surface separating the cloaked and uncloaked regions. We also consider the effect on invisibility of active devices inside
the cloaked region, interpreted as collections of sources and sinks or internal currents. When these conditions are overdetermined,
as happens for Maxwell’s equations, generic internal currents prevent the existence of finite energy solutions and invisibility
is compromised.
We give two basic constructions for cloaking a region D contained in a domain , from detection by measurements made at of Cauchy data of waves on Ω. These constructions, the single and double coatings, correspond to surrounding either just the outer boundary of the cloaked region, or both and , with metamaterials whose EM material parameters (index of refraction or electric permittivity and magnetic permeability)
are conformal to a singular Riemannian metric on Ω. For the single coating construction, invisibility holds for the Helmholtz equation, but fails for Maxwell’s equations with
generic internal currents. However, invisibility can be restored by modifying the single coating construction, by either inserting
a physical surface at or using the double coating. When cloaking an infinite cylinder, invisibility results for Maxwell’s equations are valid if
the coating material is lined on with a surface satisfying the soft and hard surface (SHS) boundary condition, but in general not without such a lining, even
for passive objects. 相似文献
979.
This paper deals with comparison of efficiency of extraction techniques (solid-phase extraction, SPE and solid-phase microextraction, SPME) used for extraction of nitrate esters (ethyleneglycoldinitrate, EGDN and nitroglycerin, NG), representing the first step of the method of quantitative determination of trace concentrations of nitrate esters in water samples. EGDN and NG are subsequently determined by means of high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Optimization of SPE and SPME conditions was carried out using model water samples. Seven SPE cartridges were tested and the conditions were optimized (type of sorbent, type and volume of solvent to be used as eluent). For both nitrate esters the limit of detection (LOD) and the limit of quantification (LOQ) obtained using SPE/HPLC-UV were 0.23 microg mL(-1) and 0.70 microg mL(-1), respectively. Optimization of SPME conditions: type of SPME fibre (four fibres were tested), type and time of sorption/desorption, temperature of sorption. PDMS/DVB (polydimethylsiloxane/divinylbenzene) fibre coating proved to be suitable for extraction of EGDN and NG. For this fibre the LOD and the LOQ for both nitrate esters were 0.16 microg mL(-1) and 0.50 microg mL(-1), respectively. Optimized methods SPE/HPLC-UV and SPME/HPLC-UV were then used for quantitative determination of nitrate esters content in real water samples from the production of EGDN and NG. 相似文献
980.
Ruttens B Blom P Van Hoof S Hubrecht I Van der Eycken J Sas B Van Hemel J Vandenkerckhove J 《The Journal of organic chemistry》2007,72(15):5514-5522
An efficient convergent approach has been developed for the construction of novel, nonnatural polysubstituted carbohydrate-based macrolides. A key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against gram-positive and gram-negative bacteria, yeasts, and molds. 相似文献