Stereoselective synthesis of the C14-C24 degraded fragment of symbiodinolide

Symbiodinolide is a polyol macrolide isolated from the marine dinoflagellate Symbiodinium sp. in 2007. The C14-C24 fragment of symbiodinolide possessing the 17R/18R/21R absolute configuration, which was obtained as one of the degraded products of symbiodinolide, was synthesized stereoselectively from cis-2-butene-1,4-diol. The detailed comparison of the synthetic product with the degraded product in the spectroscopic data confirmed that the stereostructure of the C14-C24 fragment was 17R, 18R, and 21R.     

Grubbs carbene complex-catalyzed cleavage of allyl vic-diols to aldehydes with a co-oxidant: application to the selective cleavage of huge marine molecules

An oxidative cleavage of allyl vic-diols to aldehydes catalyzed by a Grubbs carbene complex using a co-oxidant has been established for the first time, with good yields. The utility of this selective cleavage reaction was demonstrated through the use of two huge marine molecules, symbiodinolide and N-p-BrBz palytoxin.     

Massive rigid string model and its supersymmetric extension

We discuss a rigid string model proposed by Casalbuoni and Longhi. Constraints for the massive states are solved to find the physical states and the mass spectrum. We also find its supersymmetric extension with the kappa symmetry. The supersymmetry transformations are found starting from on-shell transformations using the Dirac bracket.     

Stereocontrolled synthesis of 8,11-dideoxytetrodotoxin,unnatural analogue of puffer fish toxin

[structure: see text] 8,11-Dideoxytetrodotoxin, an unnatural tetrodotoxin analogue, was synthesized in a highly stereoselective manner from a common intermediate in our synthetic studies on tetrodotoxin. The synthesis features neighboring group participation of trichloroacetamide for stereoselective hydroxylation, protection of ortho ester, and guanidine installation with Boc-protected isothiourea.     

Carbon-13 NMR studies of the biologically active nor-diterpenoid dilactones from Podocarpus plants

Carbon-13 NMR signals of the biologically active norditerpenoid dilactones from Podocarpus plants were fully assigned by using selective ¹H decoupling, coupling constants (²J_CH), spin-lattice relaxation times (T₁) and correlation of the spectra of more than thirty dilactone congeners. The spectra of five nagilactones, B, C, D, E and F, which constitute representative members of three major structural types of the dilactones: (A) 8:14, 9:11-dienolide (α-pyrone) type, (B) 7α:8α-epoxy-9:11-enolide type, and (C) 7:8,9:11-dienolide type, were extensively analysed. Some characteristic steric interactions for the substituents on the ring system can be demonstrated from the spectral properties.     

Theory of the spin depolarisation rate of μ+ SR in pure Fe

The diffusion constant (D) and the spin depolarisation rate (λ_S) of the positive muon in the ferromagnetic b.c.c. lattices such as Fe have been calculated on the basis of the small polaron (SP) model with particular attention to the hopping and the coherent motions. They have been obtained in the forms: $\text{D=}\text{d}{}^2\text{w}{}_{\mathrm{D}}\text{6}$ and $\text{λ}{}_{\mathrm{S}}\text{=}\text{4γ}{}^2{}_{\mathrm{\mu }}\text{H}{}^2{}_{\mathrm{d}}\text{3w}{}_{\mathrm{S}}$, where d is a jump length, and H_d is a magnitude of internal dipolar field. At high temperatures, the activated-type hopping motion gives a dominant contribution to w_D, and w_S coincides with w_D. With decreasing temperature, w_D turns to be increasing owing to the coherent motion. Whereas w_S deviates from w_D, after passing the minimum, to have a maximum, and then decreases in inverse proportion to a lifetime (_B) of the SP band states. Because of the cell periodicity of the internal fields, the spin in an SP band state feels a definite magnetic field corresponding to the state, and sees various fields if scattered to other states. These scattering processes succeeding in a time shorter than (γ_μH_d)^-1 result in the motional narrowing of the spectra, with λ_{S ?} γ²_μH_d_B.