Simultaneous determination of myo-inositol and scyllo-inositol by MEKC as a rapid monitoring tool for inositol levels

A simple and rapid MEKC method was developed for the simultaneous determination of myo-inositol, scyllo-inositol, and glucose. Prior to electrophoretic separation, the nonfluorescent inositols and glucose were derivatized by N-methylisatoic anhydride at 25 degrees C for 10 min so that they could be detected by a fluorescence detector during separation. The good separation with high efficiency by MEKC was achieved in 13 min with a glycine buffer containing SDS and PEG 4000. Several parameters affecting the separation were studied, including the pH of BGE, the concentrations of glycine, SDS, and PEG 4000, and the applied voltage. Using glycerol as an internal standard, the linear ranges of the method for myo-inositol, scyllo-inositol, and glucose were 0.03-10, 0.01-5, and 0.05-20 mM; the concentration LODs of myo-inositol, scyllo-inositol, and glucose were 0.020, 0.0078, and 0.026 mM, respectively. The method was applied to analyze extracellular myo-inositol and glucose in the microdialysates from rat brain cortex of ischemia animal model and intracellular myo-inositol and scyllo-inositol in the rat brain extract.     

N,N-Disubstituted-4-aminophenylazostyrylformate derivatives: their synthesis,mesogenic behaviour and photostability

A series of new azo dye liquid crystals was prepared by the reaction of the N,N-disubstituted-4-aminophenylazobenzaldehydes with butyl cyanoacetate in the presence of piperidine in refluxing ethanol. The new azo dye liquid crystals possess a SmA phase, and representative samples were found to be reasonably photostable.     

CATV/ROF transport systems based on light injection/optoelectronic feedback techniques and photonic crystal fiber

A directly modulated CATV/radio-on-fiber (ROF) transport system based on light injection and optoelectronic feedback techniques, and photonic crystal fiber (PCF) is proposed and demonstrated. Excellent performances of carrier-to-noise ratio (CNR), composite second order (CSO) and composite triple beat (CTB) were obtained for CATV band; as well as low bit error rate (BER) and third order intermodulation distortion to carrier ratio (IMD₃/C) values were achieved for ROF band. This demonstrated that such a CATV/ROF transport system is very attractive for the fiber backbone applications.     

High birefringence and high resistivity isothiocyanate‐based nematic liquid crystal mixtures

The molecular structures and physical properties of several single‐ and double‐fluorinated isothiocyanatotolane, isothiocyanatocyclohexyltolane, and isothiocyanatoterphenyl compounds are reported. Two eutectic mixtures comprising these compounds are formulated and their properties evaluated. These mixtures exhibit a high birefringence, relatively low viscosity, high resistivity, and good photo and thermal stabilities. Potential applications of these mixtures for spatial light modulators, optical phased arrays, and high speed photonics are discussed.     

Variation of molecular stacking with different length of alkyl chain: synthesis,structure determination,and mesogenic study of N,N‐disubstituted aminophenylazo‐(4)‐p‐alkylbenzenes

To help understand the influence of polarity and length of the terminal alkyl chain of a molecule on the molecular stacking of a liquid crystal and on its mesogenic behaviour, four new aminophenylazo‐(4)‐p‐alkylbenzenes were prepared and one of them was further studied by single crystal structure determination. The molecular stacking based on this crystallographic data was established, and compared with that of two previously reported homologues. The mesogenic behaviour of this series of compounds was also investigated.     

The separation of selenium from sea water by adsorption colloid flotation

Adsorption colloid flotation can be applied successfully to the separation of selenium as SeO₃^2- from sea water. Separation is achieved in 5 min. The modified catalytic method of West and Ramakrishna is used to determine the selenium. The recovery of selenium based on spiked sea-water samples is 100 ± 10%. Standard addition analysis of near-shore Oahu sea water showed a value of 0.40 ± 0.12 μg l^-1.     

Cyclodextrin‐modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata

A CD‐modified capillary electrophoretic method has been developed for achiral and chiral analysis of seven bioactive compounds isolated from the fruiting body of Antrodia camphorata. Such important target analytes exhibit similar chemical structures and are known for their diverse properties including antioxidant and anticancer effects. The analytes were separated in 25 min using a pH 9.3, 20 mM sodium borate buffer containing 20 mM methyl‐β‐CD and 30 mM sulfobutylether‐β‐CD. With the exception of the optical isomer pairs (antcin B or zhankuic acid A, zhankuic acid C, and antcin A), the remaining bioactive compounds including the chiral pair antcin C were baseline‐separated. Analysis time was noticeably longer to baseline separate all of the above chiral pairs (～38 min) by adding 5% DMF to the running buffer. The migration order was reversed compared with the HPLC elution. More hydrophobic compounds complexed favorably with methyl‐β‐CD and emerged earlier in the electropherogram than their more hydrophilic counterparts which were strongly associated with sulfobutylether‐β‐CD. The simple capillary electrophoretic method developed was applicable for rapid separation and characterization of several important bioactive compounds isolated from the fruiting body of A. camphorata.     

Optimal abort landing trajectories in the presence of windshear

This paper is concerned with optimal flight trajectories in the presence of windshear. The abort landing problem is considered with reference to flight in a vertical plane. It is assumed that, upon sensing that the airplane is in a windshear, the pilot increases the power setting at a constant time rate until maximum power setting is reached; afterward, the power setting is held constant. Hence, the only control is the angle of attack. Inequality constraints are imposed on both the angle of attack and its time derivative.The performance index being minimized is the peak value of the altitude drop. The resulting optimization problem is a minimax problem or Chebyshev problem of optimal control, which can be converted into a Bolza problem through suitable transformations. The Bolza problem is then solved employing the dual sequential gradient-restoration algorithm (DSGRA) for optimal control problems. Numerical results are obtained for several combinations of windshear intensities, initial altitudes, and power setting rates.For strong-to-severe windshears, the following conclusions are reached: (i) the optimal trajectory includes three branches: a descending flight branch, followed by a nearly horizontal flight branch, followed by an ascending flight branch after the aircraft has passed through the shear region; (ii) along an optimal trajectory, the point of minimum velocity is reached at about the time when the shear ends; (iii) the peak altitude drop depends on the windshear intensity, the initial altitude, and the power setting rate; it increases as the windshear intensity increases and the initial altitude increases; and it decreases as the power setting rate increases; (iv) the peak altitude drop of the optimal abort landing trajectory is less than the peak altitude drop of comparison trajectories, for example, the constant pitch guidance trajectory and the maximum angle of attack guidance trajectory; (v) the survival capability of the optimal abort landing trajectory in a severe windshear is superior to that of comparison trajectories, for example, the constant pitch guidance trajectory and the maximum angle of attack guidance trajectory.Portions of this paper were presented at the IFAC 10th World Congress, Munich, Germany, July 27–31, 1987 (Paper No. IFAC-87-9221).This research was supported by NASA Langley Research Center, Grant No. NAG-1-516, by Boeing Commercial Airplane Company (BCAC), and by Air Line Pilots Association (ALPA). Discussions with Dr. R. L. Bowles (NASA-LRC) and Mr. C. R. Higgins (BCAC) are acknowledged.