Influence of steady background gradients on the accuracy of molecular diffusion anisotropy measurements

Spatial susceptibility variations of body components lead to local gradients of the static magnetic field. Effects of such background gradients on fractional diffusion anisotropy (FA) measurements on whole-body magnetic resonance units operating at 1.5, 3.0 and 7.0 T were analyzed theoretically and experimentally. Analytical expressions were derived for the cases of diffusion occurring in isotropic media and in tissues with cylindrical symmetry (e.g., white matter tracts or skeletal musculature). Typical magnitudes of background gradient strengths were estimated from in vivo and in vitro measurements with B0 field mapping sequences. Additionally, numerical simulations of magnetic field distributions and resulting field gradients were performed considering tissue-air interfaces in simplified geometrical arrangements. For media with isotropic diffusion, both measurements and analytical calculations showed increasing FA inaccuracy with stronger coupling between diffusion-encoding and background gradients. For cylindrical symmetry, FA values were estimated for a standard diffusion tensor imaging protocol in a realistic scenario. At 1 mm distance from a water-air interface, susceptibility-related background gradients amount to approximately 9 mT/m at 7 T and lead to a relative error of the measured FA of up to 48%. The error in the anisotropy assessment rises considerably with increasing field strength and must be taken into account especially for experimental and clinical studies on modern high-field systems.     

Tweaking the acid-sensitivity of transiently thermoresponsive Polyacrylamides with cyclic acetal repeating units

Merging the characteristics of thermoresponsive and stimuli-degradable polymers yields so-called transiently thermoresponsive polymers, which can find application for the design of injectable gels, nanoparticles, etc. within a biomedical context. Among these polymers, only a limited number is reported which shows selective degradation under mild acidic conditions. However,extension of the library of transiently thermoresponsive polymers is desired to broadening the biomaterials toolbox to suit specific needs. Three monomers were developed by modification of 2-hydroxyethylacrylamide(HEAm) via tetrahydropyranylation or-furanylation with 3,4-dihydro-2 H-pyran(DHP), 2,3-dihydrofuran(DHF) or 2,3-dihydro-5-methylfuran(MeDHF). The presence of an acetal or ketal bond provided the monomers a pH-dependent hydrolysis behavior ranging from minutes to days. RAFT polymerisation allowed for the construction of homopolymers with temperature responsive behavior and pH-dependent hydrolysis which was strongly influenced by nature of the monomeric repeating units.     

Stationary Analysis of a Fluid Queue Driven by Some Countable State Space Markov Chain

Motivated by queueing systems playing a key role in the performance evaluation of telecommunication networks, we analyze in this paper the stationary behavior of a fluid queue, when the instantaneous input rate is driven by a continuous-time Markov chain with finite or infinite state space. In the case of an infinite state space and for particular classes of Markov chains with a countable state space, such as quasi birth and death processes or Markov chains of the G/M/1 type, we develop an algorithm to compute the stationary probability distribution function of the buffer level in the fluid queue. This algorithm relies on simple recurrence relations satisfied by key characteristics of an auxiliary queueing system with normalized input rates.      

Derivation of the Euler Equations from Quantum Dynamics

We derive the Euler equations from quantum dynamics for a class of fermionic many-body systems. We make two types of assumptions. The first type are physical assumptions on the solution of the Euler equations for the given initial data. The second type are a number of reasonable conjectures on the statistical mechanics and dynamics of the Fermion Hamiltonian.©2003 B. Nachtergaele and H.-T. Yau. This article may be reproduced in its entirety for non-commercial purposes.Research partially supported by NSF # DMS-0070774.Research partially supported by NSF # DMS-0072098, the Veblen Fund from the Institute for Advanced Study and a Fellowship from the MacArthur Foundation.     

Nonlinear modelling and control of a common rail injection system for diesel engines

Modern trends in designing mechatronic systems call for a synergic design of the separated subsystems (mechanic, electronic parts, control modules, etc.) concurring to the overall performance. Following this point of view, this paper presents a control oriented model and a nonlinear control design for a Common Rail injection system. First a model is developed, which is tuned in a virtual simulation environment, representing the injection system in details in a reliable replication of reality. Then a sliding mode control is developed. Both the model of the injection process and of the control law are validated by a virtual detailed simulation environment. The prediction capability of the model and the control efficiency are clearly shown.     

Illuminating high-dimensional convex sets

A setL of points in thed-spaceE ^d is said toilluminate a familyF={S ₁, ...,S _n } ofn disjoint compact sets inE ^d if for every setS _i inF and every pointx in the boundary ofS _i there is a pointv inL such thatv illuminatesx, i.e. the line segment joiningv tox intersects the union of the elements ofF in exactly {x}.The problem we treat is the size of a setS needed to illuminate a familyF={S ₁, ...,S _n } ofn disjoint compact sets inE ^d . We also treat the problem of putting these convex sets in mutually disjoint convex polytopes, each one having at most a certain number of facets.     

A full-field approach for the elastic characterization of anisotropic materials

In the paper a procedure is described whereby the characterization of isotropic and anisotropic laminae is carried out by full-field measurement of the surface rotations under proper flexural loads. The analytic formulation does not necessarily imply a numerical calibration and the elastic constants are determined by integrating the whole experimental data on the surface of the specimen. Measurements were carried out by phase-stepped speckle interferometry using a shearometer based on Michelson design. The experimental instrumentation, including the loading device, and the procedures for the manipulation of experimental data are detailedly described; experimental results obtained on a steel specimen and a composite laminate are also reported.