Crystal and molecular structure of deoxypeganine hydrochloride dihydrate

The crystal structure of deoxypeganine DOP chloride dihydrate (1) has been established by the x-ray structural method (diffractometer, CuK radiation, 671 reflections, direct method, R = 0.094). A comparative analysis has been made of the crystal structure of (1) with that of another complex of deoxypeganine (DOP) -DOP-ZnCl₂ ·2HCl.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from khimiya Priodnykh Soedinenii, No. 3, pp. 421–425 May–June. Original article submitted June 20, 1994.     

Crystal and Molecular Structure of the Isoflavones Irilin B and Betavulgarin

The molecular structures of the isoflavones irilin B and betavulgarin, which were isolated for the first time from the aerial part of Iris tenuiflorita, were solved by x-ray structure analyses. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 319–321, July–August, 2005.     

Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture

Background  

The LAR family Protein Tyrosine Phosphatase sigma (PTPσ) has been implicated in neuroendocrine and neuronal development, and shows strong expression in specific regions within the CNS, including the subventricular zone (SVZ). We established neural stem cell cultures, grown as neurospheres, from the SVZ of PTPσ knockout mice and sibling controls to determine if PTPσ influences the generation and the phenotype of the neuronal, astrocyte and oligodendrocyte cell lineages.     

Crystal and Molecular Structure of 2,3-Tetramethylen-3,4-dihydroquinazoline

The crystal and molecular structure of the alkaolid 2,3-tetramethylen-3,4-dihydroquinazoline hydrochloride was solved by X-ray structure analysis. It was demonstrated that the crystal contains an aqua system similar to those in the isostructural 2,3-trimethylen-3,4-dihydroquinazoline (deoxypeganine), and 2,3-pentamethylen-3,4-dihydroquinazoline hydrochlorides.     

Quinazolines. 4*. Acylation of quinazoline-2,4-diones with aromatic acids chlorides in the presence of ferric chloride hexahydrate

The interaction of quinazoline-2,4-diones with aromatic acids chlorides in nitrobenzene has been investigated in the presence of FeCl₃·6H₂O. Optimum conditions for the acylation reaction have been developed, the used 4-substituted benzoyl chlorides have been put in order of relative activity, depending on the degree of their electrophilicity.     

Syntheses based on norfluorocurarine. 2. Reduction and dehydrogenation products

The bisindole compound 2β,16α,2′β,16′β(H)-tetrahydronordihydrotoxiferine consisting of two diastereoisomeric deoxytetrahydronorfluorocurarine moieties was isolated from the reduction mixture of the alkaloid norfluorocurarine. 16-Deformyl-2,16,17,20-tetrahydro-20,21-dehydronorfluorocurarine was produced by dehydrogenation of norfluorocurarine; N(β)-methyldihydrodefluorocurarine, by hydrogenation of fluorocurarine. The structures of the synthesized compounds were established by x-ray structure analyses. The configurations of the asymmetric centers in 2β,16α,2′β,16′β(H)-tetrahydronordihydrotoxiferine were determined as 2S,3S,7R,15S,16R,2′S,3′S,7′R,15′S,16′S. Inversion to the R-configuration at the C15 center was observed in N(β)-methyldihydrodefluorocurarine whereas the configurations 3S and 7R were retained. Atom C2 adopted the S-configuration in 16-deformyl-2,16,17,20-tetrahydro-20,21-dehydronorfluorocurarine.     

Crystal and molecular structure of N-(benzylimidazolyl-2)-O-methylcarbamate salts

Single crystal X-ray diffraction has been applied to determine the structure of salts — formate and hydrochloride of N-(benzylimidazolyl-2)-O-methylcarbamate (BMC). The crystal structure of BMC formate is built by a molecule of a base and two formic acid molecules, one of them protonating a BMC molecule. Hydrogen bonds in the crystal form a weakly bound one-dimensional ribbon. BMC hydrochloride crystallizes as dihydrate. Two molecules of crystallization water and Cl ion make a robust H-bonded two-dimensional layer. BMC salts are formed through the protonation of N9 atom.