Cross-coupling reactions towards the synthesis of natural products

Molecular Diversity - Cross-coupling reactions are powerful synthetic tools for the formation of remarkable building blocks of many naturally occurring molecules, polymers and biologically active...     

Profit oriented supply chain network optimization

This paper proposes a novel mixed integer linear programming model to solve a supply chain network design problem. The proposed model deals with major issues for supply chains; product quality and cost. These issues are usually solved separately, but in this paper, we investigate effects of product quality on supply chain design and transportation flow. A trade-off between raw material quality, its purchasing and reprocessing costs was considered. Assuming decision maker (DM) wishes to work with a supplier which serves a low quality raw material; this raw material should be in need of reprocessing. To avoid the reprocessing costs, a supplier which serves a high quality raw material should be chosen but at this time the DM has to face a high purchasing cost. A supply chain network which consists of multiple suppliers, manufacturers, distribution centers and retailers is tried to be designed to accomplish aforementioned above trade-offs. The paper examines and discusses the relationship between product quality and supply chain design and offers several managerial insights.     

Kinetic treatment of acoustic waves in a four‐component dusty plasma

A kinetic formulation is developed to investigate low‐frequency dust ion acoustic waves (DIAWs) and dust acoustic waves (DAWs) as well as numerically for a four‐component, collisionless, unmagnetized dusty plasma, using the linearized Vlasov–Poisson model for species obeying the Maxwellian distribution. In particular, the dynamics of low‐frequency DIAWs is investigated by considering two cases. In the first case, ions and positive dust particles are assumed to be dynamically adiabatic while the negative dust particles are static in the background. In second case, the ions are taken adiabatic, while both positive and negative dust particles are static in the background. For DAWs, the ions are assumed to be isothermal, while both positive and negative dust species are considered adiabatic. Electrons are assumed to be isothermal in all cases. The linear characteristics and Landau damping rates for DIAWs and DAWs are investigated with effects of the dust particle concentrations and different temperature ratios. It is noted that for higher values of positive dust concentration, DIAWs (DAWs) are less (more) damped. It is also observed that the damping rate increases (decreases) as T_i approaches T_e for DIAWs (DAWs). It is worth adding here that the theoretical results presented here are supported by numerical analyses and illustrations. The relevance of the study to laboratory and cosmic plasmas is also pointed out.     

The exclusive B_s\rightarrow \phi \ell^+ \ell^- decay in the two Higgs doublet models

We study the differential branching ratio, the branching ratio and the forward-backward asymmetry for exclusive decay in the two Higgs doublet model. We analyze the dependences of these quantities on the model parameters and show that these observables are highly sensitive to new physics and hence may provide a powerful probe of the SM and beyond. Received: 27 March 2002 / Revised version: 3 July 2002 / Published online: 20 September 2002 RID="a" ID="a" e-mail: gurerk@newton.physics.metu.edu.tr RID="b" ID="b" e-mail: gsevgur@metu.edu.tr     

Ferromagnetism without flat bands in thin armchair nanoribbons

Describing by a Hubbard type of model a thin armchair graphene ribbon in the armchair hexagon chain limit, one shows in exact terms, that even if the system does not have flat bands at all, at low concentration a mesoscopic sample can have ferromagnetic ground state, being metallic in the same time. The mechanism is connected to a common effect of correlations and confinement.     

Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection

Methods using liquid chromatography/mass spectrometry (LC/MS) and LC with diode array detection (DAD) in the UV range (LC/UV) were developed for the determination of low levels of the anthraquinones aloe-emodin and aloin-A (barbaloin) in aloe-based products. The methods were used to analyze several commercial products (liquids, semisolids, and solids) for the 2 anthraquinones. The wavelengths used for quantification of aloin-A, aloe-emodin, and emodin (internal standard) by DAD were 357, 257, and 289 nm, respectively. The on-column sensitivities were 0.25 and 0.05 ng by LC/UV and 0.01 and 0.025 ng by LC/MS for aloin-A and aloe-emodin, respectively. The methods are simple and sensitive and provide reproducible results; therefore, they are suitable for the determination of these anthraquinones in various aloe-based products.     

Concise,Enantioselective, and Versatile Synthesis of (−)‐Englerin A Based on a Platinum‐Catalyzed [4C+3C] Cycloaddition of Allenedienes

A practical synthesis of (?)‐englerin A was accomplished in 17 steps and 11 % global yield from commercially available achiral precursors. The key step consists of a platinum‐catalyzed [4C+3C] allenediene cycloaddition that directly delivers the trans‐fused guaiane skeleton with complete diastereoselectivity. The high enantioselectivity (99 % ee) stems from an asymmetric ruthenium‐catalyzed transfer hydrogenation of a readily assembled diene–ynone. The synthesis also features a highly stereoselective oxygenation, and a late‐stage cuprate alkylation that enables the preparation of previously inaccessible structural analogues.     

Synthesis,characterization, antioxidant,antimicrobial and DNA binding properties of ruthenium(II), cobalt(II) and nickel(II) complexes of Schiff base containing o-vanillin

Research on Chemical Intermediates - In this study, the complex combinations of Ru(II), Co(II) and Ni(II) with Schiff base obtained through the condensation of (E)-methyl...     

Manufacturing Man‐Made Magnetosomes: High‐Throughput In Situ Synthesis of Biomimetic Magnetite Loaded Nanovesicles

A new synthetic method for the production of artificial magnetosomes, i.e., lipid‐coated vesicles containing magnetic nanoparticles, is demonstrated. Magnetosomes have considerable potential in biomedical and other nanotechnological applications but current production methods rely upon magnetotactic bacteria which limits the range of sizes and shapes that can be generated as well as the obtainable yield. Here, electrohydrodynamic atomization is utilized to form nanoscale liposomes of tunable size followed by electroporation to transport iron into the nanoliposome core resulting in magnetite crystallization. Using a combination of electron and fluorescence microscopy, dynamic light scattering, Raman spectroscopy, and magnetic susceptibility measurements, it is shown that single crystals of single‐phase magnetite can be precipitated within each liposome, forming a near‐monodisperse population of magnetic nanoparticles. For the specific conditions used in this study the mean particle size is 58 nm (±8 nm) but the system offers a high degree of flexibility in terms of both the size and composition of the final product.