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71.
Watanabe Sou Senzaki Tatsuya Shibata Atsuhiro Nomura Kazunori Takeuchi Masayuki Nakatani Kiyoharu Matsuura Haruaki Horiuchi Yusuke Arai Tsuyoshi 《Journal of Radioanalytical and Nuclear Chemistry》2019,322(3):1273-1277
Journal of Radioanalytical and Nuclear Chemistry - Extraction chromatography flow-sheet employing octyl(phenyl)-N,N-diisobutylcarbonoylmethylphosphine oxide and bis(2-ethylhexyl) hydrogen phosphate... 相似文献
72.
Mamdouh Nabil Samy Ashraf Nageeb El-Sayed Hamed Sachiko Sugimoto Hideaki Otsuka Mohamed Salah Kamel 《Natural product research》2016,30(8):967-972
A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses. Compounds 1 and 2 showed a moderate DPPH radical scavenging activity (IC50: 52.6 ± 1.70 and 41.3 ± 0.25 μM, respectively) comparable with that of the standard trolox (16.6 ± 2.2 μM) without any significant cytotoxicity towards human cell line A549 (IC50 > 100 μM). 相似文献
73.
Nakayama T Kurosawa Y Furui S Kerman K Kobayashi M Rao SR Yonezawa Y Nakano K Hino A Yamamura S Takamura Y Tamiya E 《Analytical and bioanalytical chemistry》2006,386(5):1327-1333
Polymerase chain reaction (PCR) is an essential part of research based on genomics or cell analysis. The development of a
microfluidic device that would be suitable for high-temperature-based reactions therefore becomes an important contribution
towards the integration of micro-total analysis systems (μTAS). However, problems associated with the generation of air bubbles
in the microchannels before the introduction of the assay liquid, which we call the “initial start-up” in this study, made
the flow irregular and unstable. In this report, we have tried to address these problems by adapting a novel liquid-flow method
for high-temperature-based reactions. A PDMS-based microfluidic device was fabricated by soft-lithography techniques and placed
on a cartridge heater. The generation of the air bubbles was prevented by introducing the fluorinated oil, an inert and highly
viscous liquid, as the cap just before the introduction of the sample solutions into the microchannels. The technique was
applied for continuous-flow PCR, which could perform PCR on-chip in a microfluidic system. For the evaluation of practical
accuracy, plasmid DNA that serves as a reference molecule for the quantification of genetically modified (GM) maize was used
as the template DNA for continuous-flow PCR. After PCR, the products were collected in a vial and analyzed by gel electrophoresis
to confirm the accuracy of the results. Additionally, quantitative continuous-flow PCR was performed using TaqMan technology
on our PCR device. A laser detection system was also used for the quantitative PCR method. We observed a linear relationship
between the threshold cycle (Ct) and the initial DNA concentration. These results showed that it would be possible to quantify
the initial copies of the template DNA on our microfluidic device. Accurate quantitative DNA analysis in microfluidic systems
is required for the integration of PCR with μTAS, thus we anticipate that our device would have promising potential for applications
in a wide range of research. 相似文献
74.
The idea of quality by design (QbD) has been proposed in pharmaceutical field. QbD is a systematic approach to control the product performance based on the scientific understanding of the product quality and its manufacturing process. In the present study, near-infrared (NIR) imaging is utilized as a tool to achieve this concept. A practical use of a chemometrics technique called self-modeling curve resolution (SMCR) is demonstrated with NIR imaging analysis of pharmaceutical tablets containing two ingredients, a soluble active ingredient, pentoxifylline (PTX), and an insoluble excipient, palmitic acid. Concentration profiles obtained by SMCR reveal that the homogenous distribution of chemical ingredients strongly depends on the grinding time and that its process plays a central role in quantitative control, say sustained-release of PTX. In addition, pure component spectra by SMCR indicate a sequential change of specific NIR peak intensities following the increase of the grinding time. The spectra change shows a molecular structure change related to its crystallinity during grinding process. Accordingly, this study clearly demonstrates that NIR imaging combined with SMCR can be a powerful tool to reveal chemical or physical mechanism induced by the manufacturing process of pharmaceutical products and that it may be a solid solution for QbD of pharmaceutical products. 相似文献
75.
Azido-protected Fmoc-Lys-OH (Fmoc-Lys(N3)-OH) was synthesized from Fmoc-Lys-OH by the copper(II)-catalyzed diazo transfer method, and introduced to a peptide by the ordinary Fmoc-based solid-phase peptide synthesis. This azido peptide could be condensed with a peptide thioester by the Ag+-free thioester method without any significant side reactions. The azido group was easily reduced to an amino group by Zn powder after peptide condensation. 相似文献
76.
Yuji Shinohara Tsuyoshi Nakajima Satoshi Suzuki 《Journal of Molecular Structure》1999,460(1-3):231-244
Using a semi-empirical molecular orbital method, PM3, and 2-propanol as an example, the dehydration and the dehydrogenation processes of alcohol on oxide catalysts were studied. The catalysts addressed here were four kinds of oxides (Al2O3, SiO2, ZnO, CdO) whose reaction selectivities had been experimentally determined. The usual models consisting of a surface metal ion, several oxide ions and an isopropoxy group were used in calculations. For the dehydration, heats of formation of the models were calculated at each point of the process where the distance between a β-hydrogen of the group and a basic site (i.e. oxygen of the group or a surface oxide ion) or a metal ion was gradually shortened, or where the length of the C–O bond of the group was gradually increased. A reasonable dehydration mechanism was estimated by comparing activation energies calculated from the transitions of the heats of formation. The most probable dehydrogenation mechanism was also estimated in a similar way by gradually making an -hydrogen close to a surface oxide ion, the metal ion or a surface proton. It was concluded that the dehydration proceeds by scission of the C–O bond of the group after its oxygen was attacked by some electrophile on the surface and that the dehydrogenation proceeds by a mechanism in which an -hydrogen of the group was extracted by the metal ion.
Based on the dehydration mechanism thus deduced, alkoxy groups generated by adsorption of the primary, secondary and tertiary alcohols on SiO2 were calculated in order to estimate the activation energies of their decompositions. In result, the order of the energies was found to be in good agreement with that of the decomposition rates experimentally determined by Kitahara. This agreement gives support to the validity of the mechanism deduced for the dehydration of alcohol. 相似文献
77.
Nagata M Kondo M Suemori Y Ochiai T Dewa T Ohtsuka T Nango M 《Colloids and surfaces. B, Biointerfaces》2008,64(1):16-21
Dialkyl disulfide-linked naphthoquinone, (NQ-Cn-S)2, and anthraquinone, (AQ-Cn-S)2, derivatives with different spacer alkyl chains (Cn: n = 2, 6, 12) were synthesized and these quinone derivatives were self-assembled on a gold electrode. The formation of self-assembled monolayers (SAMs) of these derivatives on a gold electrode was confirmed by infrared reflection-absorption spectroscopy (IR-RAS). Electron transfer between the derivatives and the gold electrode was studied by cyclic voltammetry. On the cyclic voltammogram a reversible redox reaction between quinone (Q) and hydroquinone (QH2) was clearly observed under an aqueous condition. The formal potentials for NQ and AQ derivatives were −0.48 and −0.58 V, respectively, that did not depend on the spacer length. The oxidation and reduction peak currents were strongly dependent on the spacer alkyl chain length. The redox behavior of quinone derivatives depended on the pH condition of the buffer solution. The pH dependence was in agreement with a theoretical value of E1/2 (mV) = E′ − 59pH for 2H+/2e− process in the pH range 3–11. In the range higher than pH 11, the value was estimated with E1/2 (mV) = E′ − 30pH , which may correspond to H+/2e− process. The tunneling barrier coefficients (β) for NQ and AQ SAMs were determined to be 0.12 and 0.73 per methylene group (CH2), respectively. Comparison of the structures and the alkyl chain length of quinones derivatives on these electron transfers on the electrode is made. 相似文献
78.
Kawasaki T Suzuki K Hatase K Otsuka M Koshima H Soai K 《Chemical communications (Cambridge, England)》2006,(17):1869-1871
Enantiomorphous crystals composed of achiral hippuric acid, i.e., naturally occurring N-benzoylglycine, have been used successfully as chiral inducers in enantioselective synthesis in combination with asymmetric autocatalysis to afford the product with extremely high enantiomeric excess. 相似文献
79.
A novel oxidative cyclization of quinone-arenols 5 leading to products 6 with a dibenzofuran-1,4-dione structure, which forms the core of several natural products, has been developed and applied to the synthesis of violet-quinone (4). 相似文献
80.
1-Chlorovinyl p-tolyl sulfoxides were synthesized from ketones and chloromethyl p-tolyl sulfoxide in high yields. Treatment of the sulfoxides with isopropylmagnesium chloride at −78 °C in toluene gave magnesium alkylidene carbenoids (α-chloro alkenylmagnesium chlorides), which were treated with N-lithio arylamines to afford ortho-alkenylated arylamines in moderate yields. The reaction, in some cases, proceeded in a highly stereospecific manner at the carbon bearing the chlorine and the sulfinyl group. The structures of the α-chloro alkenylmagnesium chlorides and the reactivity of the N-lithio meta-substituted anilines were studied at the B3LYP and MP2 levels of theory with the 6-31(+)G* basis set. This reaction offers a quite novel and direct alkenylation of arylamines at the ortho-position of the aromatic ring. 相似文献