Zinc-containing derivatives of 2-aminopyrimidine

A platform containing three anticancer components is proposed. The components are a radioactive ⁶⁹mZn isotope and zinc complexes, where both zinc and ligand exhibit anticancer properties. Two zinc-containing complexes, namely (2-AP)₂ZnCl₂ and (2-AP)₂Zn(Sal)₂ (AP is 2-aminopyrimidine, Sal is salicylate) were synthesized and characterized. Their cytotoxicity with respect to some leukemia cell lines is demonstrated. Their stability in physiological solution and percentage of apoptosis (by flow cytometry) are investigated. Stable complexes of compounds with the isotope ⁶⁹mZn were characterized by TLC and autoradiography.     

Short- and long-range order balance in nanocrystalline Gd2Zr2O7 powders with a fluorite-pyrochlore structure

A series of nanocrystalline Gd₂Zr₂O₇ powders has been studied using a combination of X-ray diffraction and X-ray spectroscopy with synchrotron radiation. It has been shown that isothermal annealing of an X-ray amorphous mixed hydroxide first leads to the formation of an oxide nanomaterial with a defect fluorite structure and clearly pronounced nonequivalence of the local environment of the Gd³⁺ and Zr⁴⁺ ions. Increasing heat treatment temperature results in initiation and growth of nanodomains with pyrochlore-type superstructure ordering of cations inside bulkier crystallites of defect fluorite. To adequately describe the evolution of the real nanocrystalline structure of gadolinium zirconate, a combination of X-ray structural methods sensitive to the averaged crystal structure and local atomic structure should be used.     

Modified hydroxyapatite as a carrier for 69mZn

Russian Chemical Bulletin - Sorption of zinc ions and 69mZn radionuclide proceeds much more rapidly on hydroxyapatite modified with zinc ions (HAP-Zn) than on unmodified HAP. The sorption can be...     

Enhancement of electrostatic interactions upon the transition from solutions to crystals of polynitro compounds

Institute of Chemical Physics, Academy of Sciences of the USSR. Translated from Zhurnal Strukturnoi Khimii, Vol. 29, No. 2, pp. 172–174, March–April, 1988.     

A flavonoid glycoside and hydrocarbons and sterols from Thalictrum simplex

Irkutsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 723–724, November–December, 1992.