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71.
Tânia Cecília Trevisan Evandro Luiz Dall’Oglio Eudes da Silva Velozo Paulo Teixeira de Sousa Jr. 《Tetrahedron letters》2008,49(44):6289-6292
The phytochemical investigation of the methanol crude extract obtained from Acosmium dasycarpum (Vog.) Yakovlev root bark led to the isolation of the quinolizidine alkaloids lupanine, acosmine, acosminine and lupanacosmine, as well as the diaza-adamantane alkaloids panacosmine and dasycarpumine. Lupanacosmine (4) and dasycarpumine (6) have been described for the first time herein. 相似文献
72.
Dr. Chiara Nardon Dr. Federica Chiara Leonardo Brustolin Dr. Alberto Gambalunga Dr. Francesco Ciscato Dr. Andrea Rasola Prof. Andrea Trevisan Prof. Dolores Fregona 《ChemistryOpen》2015,4(2):183-191
Transition metals offer many possibilities in developing potent chemotherapeutic agents. They are endowed with a variety of oxidation states, allowing for the selection of their coordination numbers and geometries via the choice of proper ligands, leading to the tuning of their final biological properties. We report here on the synthesis, physico-chemical characterization, and solution behavior of two gold(III) pyrrolidinedithiocarbamates (PDT), namely [AuIIIBr2(PDT)] and [AuIIICl2(PDT)]. We found that the bromide derivative was more effective than the chloride one in inducing cell death for several cancer cell lines. [AuIIIBr2(PDT)] elicited oxidative stress with effects on the permeability transition pore, a mitochondrial channel whose opening leads to cell death. More efficient antineoplastic strategies are required for the widespread burden that is cancer. In line with this, our results indicate that [AuIIIBr2(PDT)] is a promising antineoplastic agent that targets cellular components with crucial functions for the survival of tumor cells. 相似文献
73.
A. H. Rosa A. A. Vicente J. C. Rocha H. C. Trevisan 《Analytical and bioanalytical chemistry》2000,368(7):730-733
Invertase was immobilized on aminopropyl silica (APTS-SiO2) activated with humic substances (APTS-SiO2-HS) and on aminopropyl silica activated with glutaraldehyde (APTS-SiO2-GA). The resulting activity of both systems was compared. Humic substances (HS) used for the activation of the silica were extracted from soil of Cananéia, São Paulo State, Brazil, according to the procedure recommended by the International Humic Substances Society. Activity was determined by measuring the rate of formation of reduced sugars using the reaction with dinitrosalicylic acid (DNS). The amount of HS bound on the APTS-SiO2 was equal to 50 mg. The maximum amount of invertase immobilized on APTS-SiO2-HS was 15200 U/g while in the system APTS-SiO2-GA it was 13400 U/g. The experimental enzymatic activity was 3700 and 3300 U/g, for the systems APTS-SiO2-HS and APTS-SiO2-GA, respectively. Considering the increased amount and activity of immobilized enzyme compared with the glutaraldehyde method, it was concluded that this technique opens a new perspective in the preparation of supports for enzyme immobilization employing humic substances. 相似文献
74.
Jemma G. Kelly Plamen P. Angelov Júlio Trevisan Anastasia Vlachopoulou Evangelos Paraskevaidis Pierre L. Martin-Hirsch Francis L. Martin 《Analytical and bioanalytical chemistry》2010,398(5):2191-2201
Although the UK cervical screening programme has reduced mortality associated with invasive disease, advancement from a high-throughput
predictive methodology that is cost-effective and robust could greatly support the current system. We combined analysis by
attenuated total reflection Fourier-transform infrared spectroscopy of cervical cytology with self-learning classifier eClass.
This predictive algorithm can cope with vast amounts of multidimensional data with variable characteristics. Using a characterised
dataset [set A: consisting of UK cervical specimens designated as normal (n = 60), low-grade (n = 60) or high-grade (n = 60)] and one further dataset (set B) consisting of n = 30 low-grade samples, we set out to determine whether this approach could be robustly predictive. Variously extending the
training set consisting of set A with set B data produced good classification rates with three two-class cascade classifiers.
However, a single three-class classifier was equally efficient, producing a user-friendly, applicable methodology with improved
interpretability (i.e., better classification with only one set of fuzzy rules). As data from set B were added incrementally
to the training set, the model learned and evolved. Additionally, monitoring of results of the set B low-grade specimens (known
to be low-grade cervical cytology specimens) provided the opportunity to explore the possibility of distinguishing patients
likely to progress towards invasive disease. eClass exhibited a remarkably robust predictive power in a user-friendly fashion
(i.e., high throughput, ease of use) compared to other classifiers (k-nearest neighbours, support vector machines, artificial neural networks). Development of eClass to classify such datasets
for applications such as screening exhibits robustness in identifying a dichotomous marker of invasive disease progression. 相似文献
75.
Daniel Josiane S. P. Cruz Jonas C. Catelani Tiago A. Garcia Jerusa S. Trevisan Marcello G. 《Journal of Thermal Analysis and Calorimetry》2021,143(4):3127-3135
Journal of Thermal Analysis and Calorimetry - This study aims to characterize erythromycin (ERY) estolate by thermogravimetry analysis and differential scanning calorimetry. For such a purpose,... 相似文献
76.
Helane?MS?Costa Augusto?CV?Freitas Júnior Ian?PG?Amaral Izaura?Y?Hirata Patrícia?MG?Paiva Luiz?B?CarvalhoJr Vitor?Oliveira Ranilson?S?BezerraEmail author 《Chemistry Central journal》2013,7(1):166
Background
Over the past decades, the economic development and world population growth has led to increased for food demand. Increasing the fish production is considered one of the alternatives to meet the increased food demand, but the processing of fish leads to by-products such as skin, bones and viscera, a source of environmental contamination. Fish viscera have been reported as an important source of digestive proteases with interesting characteristics for biotechnological processes. Thus, the aim of this study was to purify and to characterize a trypsin from the processing by-products of crevalle jack (Caranx hippos) fish.Results
A 27.5 kDa trypsin with N-terminal amino acid sequence IVGGFECTPHVFAYQ was easily purified from the pyloric caeca of the crevalle jack. Its physicochemical and kinetic properties were evaluated using N-α-benzoyl-DL-arginine-p-nitroanilide (BApNA) as substrate. In addition, the effects of various metal ions and specific protease inhibitors on trypsin activity were determined. Optimum pH and temperature were 8.0 and 50°C, respectively. After incubation at 50°C for 30 min the enzyme lost only 20% of its activity. K m , kcat, and k cat /K m values using BApNA as substrate were 0.689 mM, 6.9 s-1, and 10 s-1 mM-1, respectively. High inhibition of trypsin activity was observed after incubation with Cd2+, Al3+, Zn2+, Cu2+, Pb2+, and Hg2+ at 1 mM, revealing high sensitivity of the enzyme to metal ions.Conclusions
Extraction of a thermostable trypsin from by-products of the fishery industry confirms the potential of these materials as an alternative source of these biomolecules. Furthermore, the results suggest that this trypsin-like enzyme presents interesting biotechnological properties for industrial applications.77.
Bais D Trevisan A Lapasin R Partal P Gallegos C 《Journal of colloid and interface science》2005,290(2):546-556
Rheometrical techniques can be profitably used for polysaccharide matrices in order to evaluate their suitability for the preparation of stable cosmetic O/W emulsions. In particular, the rheological properties of aqueous scleroglucan systems were investigated under continuous and oscillatory shear conditions in a polymer concentration range (0.2-1.2% w/w) embracing the sol/gel transition. The effects due to the addition of two different surfactants (up to 10% w/w) were examined at constant polymer concentration (0.4% w/w). The selected additives are a nonionic polymeric siliconic surfactant (dimethicone copolyol) and a cationic surfactant (tetradecyltrimethylammonium bromide), respectively. Polysaccharide-surfactant interactions leading to complex formation were detected also through rheology. The combined action of both nonionic and cationic surfactants in the polymer solution was examined at two different surfactant concentration levels (5 and 10% w/w), demonstrating the beneficial effects produced on the mechanical properties of the polymer matrix by the coexistence of both surfactants. Such beneficial effects are confirmed by the stability and rheology shown by the emulsions prepared. In this way, the results point out the good agreement between the rheology of the continuous phase and the final characteristics of the emulsion obtained. 相似文献
78.
Property testing is a relaxation of decision problems in which it is required to distinguish YES ‐instances (i.e., objects having a predetermined property) from instances that are far from any YES ‐instance. We presents three theorems regarding testing graph properties in the adjacency matrix representation. More specifically, these theorems relate to the project of characterizing graph properties according to the complexity of testing them (in the adjacency matrix representation). The first theorem is that there exist monotone graph properties in ???? for which testing is very hard (i.e., requires to examine a constant fraction of the entries in the matrix). The second theorem is that every graph property that can be tested making a number of queries that is independent of the size of the graph can be so tested by uniformly selecting a set of vertices and accepting iff the induced subgraph has some fixed graph property (which is not necessarily the same as the one being tested). The third theorem refers to the framework of graph partition problems, and is a characterization of the subclass of properties that can be tested using a one‐sided error tester making a number of queries that is independent of the size of the graph. © 2003 Wiley Periodicals, Inc. Random Struct. Alg., 23: 23–57, 2003 相似文献
79.
Lorenzo Codecasa Ruben Specogna Francesco Trevisan 《Journal of computational physics》2010,229(19):7401-7410
By exploiting the geometric structure behind Maxwell’s equations, the so called discrete geometric approach allows to translate the physical laws of electromagnetism into discrete relations, involving circulations and fluxes associated with the geometric elements of a pair of interlocked grids: the primal grid and the dual grid. 相似文献
80.
A De A Mitra A Ray SR Banerjee M Sengupta A Chatterjee S Kailas HS Patel MG Betigiri SK Dutta 《Pramana》1999,53(3):549-552
In this paper, we report our measurements of back-angle oxygen and carbon particle yields from 16O+89Y, 12C+93Nb reactions forming the same compound nucleus 105Ag at the same excitation energy and spin distribution. We find anomalously large oxygen yield and entrance channel dependence
at high excitation energies from 16O+89Y reaction implying formation of a dinuclear orbiting complex. Possible connection between nuclear orbiting and fast fission
is also discussed. 相似文献