On-shell mediator dark matter models and the Xenon1T excess

We present a dark matter model to explain the excess events in the electron recoil data recently reported by the Xenon1 T experiment. In our model, dark matter χ annihilates into a pair of on-shell particles Φ, which subsequently decay into the ψψ final state;ψ interacts with electrons to generate the observed excess events. Because of the mass hierarchy, the velocity of ψ can be rather large and can have an extended distribution, providing a good fit to the electron recoil energy spectrum. We estimate the flux of ψ from dark matter annihilations in the galaxy and further determine the interaction cross section, which is sizable but sufficiently small to allow ψ to penetrate the rocks to reach the underground labs.     

Integrating Allyl Electrophiles into Nickel-Catalyzed Conjunctive Cross-Coupling

Allylation and conjunctive cross-coupling represent two useful, yet largely distinct, reactivity paradigms in catalysis. The union of these two processes would offer exciting possibilities in organic synthesis but remains largely unknown. Herein, we report the use of allyl electrophiles in nickel-catalyzed conjunctive cross-coupling with a non-conjugated alkene and dimethylzinc. The transformation is enabled by weakly coordinating, monodentate aza-heterocycle directing groups that are useful building blocks in synthesis, including saccharin, pyridones, pyrazoles, and triazoles. The reaction occurs under mild conditions and is compatible with a wide range of allyl electrophiles. High chemoselectivity through substrate directivity is demonstrated by the facile reactivity of the β-γ alkene of the starting material, whereas the ϵ-ζ alkene of the product is preserved. The generality of this approach is further illustrated through the development of an analogous method with alkyne substrates. Mechanistic studies reveal the importance of the dissociation of the weakly coordinating directing group to allow the allyl moiety to bind and facilitate C(sp³)−C(sp³) reductive elimination.     

Rapid,Quantitative, and Ultrasensitive Point‐of‐Care Testing: A Portable SERS Reader for Lateral Flow Assays in Clinical Chemistry

The design of a portable Raman/SERS‐LFA reader with line illumination using a custom‐made fiber optic probe for rapid, quantitative, and ultrasensitive point‐of‐care testing (POCT) is presented. The pregnancy hormone human chorionic gonadotropin (hCG) is detectable in clinical samples within only 2–5 s down to approximately 1.6 mIU mL^?1. This acquisition time is several orders of magnitude shorter than those of existing approaches requiring expensive Raman instrumentation, and the method is 15‐times more sensitive than a commercially available lateral flow assay (LFA) as the gold standard. The SERS‐LFA technology paves the way for affordable, quantitative, and ultrasensitive POCT with multiplexing potential in real‐world applications, ranging from clinical chemistry to food and environmental analysis as well as drug and biowarfare agent testing.     

A Transient-Directing-Group Strategy Enables Enantioselective Reductive Heck Hydroarylation of Alkenes

Metal-coordinating directing groups have seen extensive use in the field of transition-metal-catalyzed alkene functionalization; however, their waste-generating installation and removal steps limit the efficiency and practicality of reactions that rely on their use. Inspired by developments in asymmetric organocatalysis, where reactions rely on reversible covalent interactions between an organic substrate and a chiral mediator, we have developed a transient-directing-group approach to reductive Heck hydroarylation of alkenyl benzaldehyde substrates that proceeds under mild conditions. Highly stereoselective migratory insertion is facilitated by in situ formation of an imine from catalytic amounts of a commercially available amino acid additive. Computational studies reveal an unusual mode of enantioinduction by the remote chiral center in the transient directing group.     

Brønsted Acidic Ionic Liquid-Catalyzed Synthesis of 14-Aryl-14H-dibenzo[a,j]xanthenes with Controlled Microwave Heating under Solvent-Free Conditions

Russian Journal of Organic Chemistry - 1-Methyl-3-sulfo-1H-imidazol-3-ium chloride ([Msim]Cl) catalyzed the condensation of β-naphthol with aromatic aldehydes under microwave irradiation. This...     

Determination of Chlorpyrifos Pesticide Residue in Bell Peppers Grown in Dalat (Vietnam) by GC-MS/MS Using QuEChERS Extraction

Journal of Analytical Chemistry - Triple quadrupole mass spectrometry was used for the direct, quick and quantitative determination of chlorpyrifos residue in bell peppers using the QuEChERS...     

Chemical Constituents and Biological Activities of the Leaves of Knema saxatilis

Chemistry of Natural Compounds -