An Isotope‐Coded Fluorogenic Cross‐Linker for High‐Performance Target Identification Based on Photoaffinity Labeling

A photoaffinity labeling (PAL)‐based method for the rapid identification of target proteins is presented in which a high‐performance chemical tag, an isotope‐coded fluorescent tag (IsoFT), can be attached to the interacting site by irradiation. Labeled peptides can be easily distinguished among numerous proteolytic digests by sequential detection with highly sensitive fluorescence spectroscopy and mass spectrometry. Subsequent MS/MS analysis provides amino acid sequence information with a higher depth of coverage. The combination of PAL and heterogeneous target‐selecting techniques significantly reduces the amount of time and protein required for identification. An additional photocleavable moiety successfully accelerated proteomic analysis using cell lysate. This method is a widely applicable approach for the rapid and accurate identification of interacting proteins.     

Polynomially convex hulls of graphs on the sphere

Let be the graph of a continuous map of the unit sphere of into , and the polynomially convex hull of . Several examples of for are given, which have different properties from the known ones for .

     

Beam-size measurement with optical diffraction radiation at KEK accelerator test facility

An experiment on the investigation of optical diffraction radiation (ODR) from a slit target as a possible tool for noninvasive electron beam-size diagnostics has been performed at the KEK accelerator test facility. The experimental setup has been installed at the diagnostics section of the extraction line. We have performed the first incoherent ODR observation from a slit target. The measured angular distributions are in reasonable agreement with the theoretical expectation. The beam-size effect onto the ODR angular pattern has been observed. Moreover, the sensitivity to the beam size as small as 14 microm has been achieved.     

An Anti CuO2‐type Metal Hydride Square Net Structure in Ln2M2As2Hx (Ln=La or Sm,M=Ti,V, Cr,or Mn)

Using a high pressure technique and the strong donating nature of H⁻, a new series of tetragonal La₂Fe₂Se₂O₃‐type layered mixed‐anion arsenides, Ln₂M₂As₂H_x, was synthesized (Ln=La or Sm, M=Ti, V, Cr, or Mn; x≈3). In these compounds, an unusual M₂H square net, which has anti CuO₂ square net structures accompanying two As³⁻ ions, is sandwiched by (LaH)₂ fluorite layers. Notably, strong metal–metal bonding with a distance of 2.80 Å was confirmed in La₂Ti₂As₂H_2.3, which has metallic properties. In fact, these compounds are situated near the boundary between salt‐like ionic hydrides and transition‐metal hydrides with metallic characters.     

Regression-based model of skin diffuse reflectance for skin color analysis

A simple regression-based model of skin diffuse reflectance is developed based on reflectance samples calculated by Monte Carlo simulation of light transport in a two-layered skin model. This reflectance model includes the values of spectral reflectance in the visible spectra for Japanese women. The modified Lambert Beer law holds in the proposed model with a modified mean free path length in non-linear density space. The averaged RMS and maximum errors of the proposed model were 1.1 and 3.1%, respectively, in the above range.     

Synthesis of macrocyclic terpenoids by intramolecular cyclization VII. Total synthesis of (±)-cubitene

Stereoselective total synthesis of (±)-cubitene, a diterpene isolated from termite soldiers, and its stereisomer has been achieved utilizing the anion-induced intramolecular cyclization.     

Biomimetic transformations of germacradienes. Stereospecific conversion of hedycaryol phenyl sulfides to cadinanes

E,E- and 2Z,6E-hedycaryol phenyl sulfides were converted by [2.3]sigmatropy of their sulfoxides to the same allyl alcohol which in turn afforded cadinane derivatives stereospecifically by the action of acids.