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991.
992.
Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity 总被引:10,自引:0,他引:10
The methanolic extracts of several natural medicines and medicinal foodstuffs were found to show an inhibitory effect on rat lens aldose reductase. In most cases, flavonoids were isolated as the active constituents by bioassay-guided separation, and among them, quercitrin (IC(50)=0.15 microM), guaijaverin (0.18 microM), and desmanthin-1 (0.082 microM) exhibited potent inhibitory activity. Desmanthin-1 showed the most potent activity, which was equivalent to that of a commercial synthetic aldose reductase inhibitor, epalrestat (0.072 microM). In order to clarify the structural requirements of flavonoids for aldose reductase inhibitory activity, various flavonoids and related compounds were examined. The results suggested the following structural requirements of flavonoid: 1) the flavones and flavonols having the 7-hydroxyl and/or catechol moiety at the B ring (the 3',4'-dihydroxyl moiety) exhibit the strong activity; 2) the 5-hydroxyl moiety does not affect the activity; 3) the 3-hydroxyl and 7-O-glucosyl moieties reduce the activity; 4) the 2-3 double bond enhances the activity; 5) the flavones and flavonols having the catechol moiety at the B ring exhibit stronger activity than those having the pyrogallol moiety (the 3',4',5'-trihydroxyl moiety). 相似文献
993.
Yoshitsugu Kojima Arimitsu Usuki Masaya Kawasumi Akane Okada Toshio Kurauchi Osami Kamigaito 《Journal of polymer science. Part A, Polymer chemistry》1993,31(7):1755-1758
Nylon 6–clay hybrid is a molecular composite of nylon 6 and uniformly dispersed silicate layers of montmorillonite. One-pot synthesis of the hybrid was carried out by the following procedures. Montmorillonite was dispersed in water, and then ε-caprolactam, acid (phosphoric acid, hydrochloric acid, benzenesulfonic acid, isophthalic acid, trichloroacetic acid, or acetic acid), and 6-aminocaproic acid were added to the dispersion. The mixtures were reacted at 260°C for 6 h, yielding the nylon 6–clay hybrids (1potNCHs). X-ray diffraction revealed that the silicate layers of 1potNCH by phosphoric acid were uniformly dispersed in the nylon 6 matrix. The 1potNCH had excellent mechanical properties. The strength and the modulus of the hybrid increased compared with previously reported nylon 6–clay hybrid (NCH) synthesized by montmorillonite intercalated with 12-aminolauric acid. The heat distortion temperature (HDT) of the 1potNCH was 160°C, which was 8°C higher than that of NCH. In other 1potNCHs, montmorillonite had a smaller effect on the increase of those properties, and interlayer spacing of montmorillonite was observed at ca. 20 Å. © 1993 John Wiley & Sons, Inc. 相似文献
994.
Hiroyuki Fukuda Yoshihiro Nakashima 《Journal of polymer science. Part A, Polymer chemistry》1983,21(5):1423-1433
Methoxymethylstyrene (MSt), (2,2-dimethyl-1,3-dioxolan-4-yl)methoxymethylstyrene (MMSt), and (2-ethyl-2-methyl-1,3-dioxolan-4-yl)methoxymethylstyrene (EMSt) were synthesized and homopolymerized and copolymerized. The photochemical behavior of resultant homopolymers and copolymers with methyl methacrylate (MMA) and styrene (St) were investigated. The infrared (IR) and ultraviolet (UV) spectra of poly(MSt) showed that new bands ascribed to methyl benzoate residue increase rapidly with irrdiation time in air, but no detectable changes are observed in vacuum. The solubility measurements of poly(MSt) indicate that the main factor in crosslinking is the direct coupling of the benzyl radical generated by UV irradiation, which was confirmed by photopolymerization of MMA by means of benzyl methyl ether. It was also found that copolymers of MMSt or EMSt with MMA or St are easily crosslinked by UV irradiation. From the results of solubility measurements of these copolymers irradiated both in air and in vaccum, it was concluded that not only the 1,3-dioxolane structure but also the benzyl methyl ether structure takes part in photocrosslinking, as we expected. 相似文献
995.
An ion-exchanger phase spectrophotometric method with disodium 1-nitroso-2-naphthol-3,6-disulphonate (Nitroso-R salt) has been developed for the determination of cobalt(II) at 0.1 mug/l. levels in sea-water. The sensitivity is about 1000 times that for conventional spectrophotometry. 相似文献
996.
The digital image processing technique was used for the extraction of physical information from the temporal image of phase structure in the process of phase separation in the blend of poly (butylene terephthalate-co-caprolactone )with polycarbonate. The power spectrum images of the two-dimensional Fourier transformation (2DFT) of the temporal image of phase structure reflect the change of the phase size with time. 相似文献
997.
Kameda M Sumaru K Kanamori T Shinbo T 《Langmuir : the ACS journal of surfaces and colloids》2004,20(21):9315-9319
The dielectric environment surrounding poly(N-isopropylacrylamide) in aqueous solution was investigated by probing with spirobenzopyran covalently attached as a side chain to the polymer main chain. Inherent characteristics of the spirobenzopyran chromophore were analyzed, and the chromophore was confirmed to be suitable to probe the local polar condition around the polymer. Measurements for an aqueous polymer solution at various temperatures elucidated that the dielectric environment surrounding the polymer changed continuously even in the temperature range far below the lower critical solution temperature. This result suggested that the local and weak orientation of water molecules around the polymer diminished continuously in a preliminary stage of shifting to thermally induced phase separation. The dielectric environment surrounding thermoresponsive polymer in aqueous solution was investigated by probing with spirobenzopyran covalently attached as a side chain to the polymer main chain. 相似文献
998.
Takamuku T Kumai T Yoshida K Otomo T Yamaguchi T 《The journal of physical chemistry. A》2005,109(34):7667-7676
To clarify the structure of solvent clusters formed in halogenoethanol-water mixtures at the molecular level, large-angle X-ray scattering (LAXS) measurements have been made at 298 K on 2,2,2-trifluoroethanol (TFE), 2,2,2-trichloroethanol (TCE), and their aqueous mixtures in the TFE and TCE mole fraction ranges of 0.002 < or = x(TFE) < or = 0.9 and 0.5 < or = x(TCE) < or = 0.9, respectively. The radial distribution functions (RDFs) for TFE-water mixtures have shown that the structural transition from inherent TFE structure to the tetrahedral-like structure of water takes place at x(TFE) approximately 0.2. In the TCE-water mixtures inherent TCE structure remains in the range of 0.5 < or = x(TCE) < or = 1. Small-angle neutron scattering (SANS) experiments have been performed on CF(3)CH(2)OD- (TFE-d(1)-) D(2)O and CF(3)CD(2)OH- (TFE-d(2)-) H(2)O mixtures in the TFE mole fraction range of 0.05 < or = x(TFE) < or = 0.8. The SANS results in terms of the Ornstein-Zernike correlation length have revealed that TFE and water molecules are most heterogeneously mixed with each other in the TFE-water mixture at x(TFE) approximately 0.15, i.e., both TFE clusters and water clusters are most enhanced in the mixture. To evaluate the dynamics of TFE and ethanol (EtOH) molecules in TFE-water and ethanol-water mixtures, respectively, (1)H NMR relaxation rates for the methylene group within alcohol molecules have been measured by using an inversion-recovery method. The alcohol concentration dependence of the relaxation rates for the TFE-water and ethanol-water mixtures has shown a break point at x(TFE) approximately 0.15 and x(EtOH) approximately 0.2, respectively, where the structural transition from alcohol clusters to the tetrahedral-like structure of water takes place. On the basis of the present results, the most likely structure models of solvent clusters predominantly formed in TFE-water and TCE-water mixtures are proposed. In addition, effects of halogenation of the hydrophobic groups on clustering of alcohol molecules are discussed from the present results, together with the previous ones for ethanol-water and 1,1,1,3,3,3-hexafluoro-2-propanol- (HFIP-) water mixtures. 相似文献
999.
Kim TH Ito H Hayashi K Hasegawa T Machiguchi T Yoshida T 《Chemical & pharmaceutical bulletin》2005,53(6):641-644
A phytochemical investigation of the polar constituents in the heartwood of Indian Santalum album L. resulted in the isolation of three new neolignans (1-3) and a new aromatic ester (4), along with 14 known components. The structures of the new compounds (1-4) were established using spectroscopic methods. 相似文献
1000.
Toshio Ogawa Masakazu Sakai 《Journal of polymer science. Part A, Polymer chemistry》1985,23(4):1109-1117
Nylon 12 has a low melting point compared with other commercial products like nylons 6 and 66. Nylon 12 was fractionated by the column elution method at 170.8-C. The same sample was also fractionated by preparative gel permeation chromatography and the molecular weight distribution of the fractions obtained by these methods was similarly determined. The weight-average molecular weight of the fractions was also found by the light scattering method. Both fractionation methods separate the sample according to molecular weight. The former, however, had narrower fractions in molecular weight distribution than the latter and it was easy to obtain a large number of fractions. It was also generally superior in practical use. 相似文献