Stereocontrolled synthesis of 7-hydroxy- and 7-acetoxy-PGI2: New stable PGI2 analogues

Stable analogues of PGI₂, 7-hydroxy- and 7-acetoxy-PGI₂, were synthesized from protected PGI₂ methyl ester $\text{1b}$via sulfoxides $\text{6a}$, $\text{6b}$ through stereocontrolled sulfoxide-sulfenate rearrangement.     

Palladium-catalyzed allylic oxidation of olefins by t-butyl hydroperoxide and tellurium(IV) oxide

Treatment of several cyclic olefins, β-pinene, allylbenzene, and estragole with palladium(II) salt in acetic acid in the presence of t-butyl hydroperoxide and tellurium(IV) oxide afforded mainly the corresponding allylic acetates. The reaction proceeded catalytically with palladium(II) salt, t-BuOOH working as a reoxidizing agent.     

A glycine receptor is involved in the organization of swimming movements in an invertebrate chordate

Background  

Rhythmic motor patterns for locomotion in vertebrates are generated in spinal cord neural networks known as spinal Central Pattern Generators (CPGs). A key element in pattern generation is the role of glycinergic synaptic transmission by interneurons that cross the cord midline and inhibit contralaterally-located excitatory neurons. The glycinergic inhibitory drive permits alternating and precisely timed motor output during locomotion such as walking or swimming. To understand better the evolution of this system we examined the physiology of the neural network controlling swimming in an invertebrate chordate relative of vertebrates, the ascidian larva Ciona intestinalis.     

Long Time Behavior of the Volume of the Wiener Sausage on Dirichlet Spaces

Potential Analysis - In the present paper, we consider long time behaviors of the volume of the Wiener sausage on Dirichlet spaces. We focus on the volume of the Wiener sausage for diffusion...     

Measurement of the vector A y and tensor A yy , A xx , A xz analyzing powers for the dd → 3H p reaction at 200 MeV

The data on the vector A _y and tensor A _yy , A _xx , A _xz analyzing powers for the d → ³H p reaction have been obtained at the energy of the initial deuteron of 200MeV in the angular range of 0–95 degrees in the c.m.s. The calculations performed within one-nucleon exchange model with the use of the standard three-nucleon bound state wave functions fail to reproduce the data on the tensor analyzing powers.     

First enantioselective synthesis of salinipostin A,a marine cyclic enol-phosphotriester isolated from Salinispora sp

Salinipostins are cyclic enol-phosphotriesters isolated from a marine-derived Salinispora sp. as antimalarial compounds. Herein, the first enantioselective synthesis of salinipostin A was achieved. Organocatalyst-mediated asymmetric cyclopropanation and regioselective cyclopropane ring opening were the key steps.