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A convenient,rapid and efficient method for the synthesis of substituted steroidal[6,7-d]thiazoles using microwave-induced organic reaction enhancement chemistry has been developed.The additional features of this methodology include a much faster reaction,easy workup,high yield,high purity of the products and an environment friendly approach. 相似文献
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A convenient, rapid and efficient method for the synthesis of substituted steroidal [6,7-d] thiazoles using microwave-induced organic reaction enhancement chemistry has been developed. The additional features of this methodology include a much faster reaction, easy workup, high yield, high purity of the products and an environment friendly approach. 相似文献
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Azharullah Khan Mahboob Alam M. Mushfiq 《中国化学快报》2008,19(9):1027-1030
A convenient, rapid and efficient method for the synthesis of substituted steroidal [6,7-d] thiazoles using microwave-induced organic reaction enhancement chemistry has been developed. The additional features of this methodology include a much faster reaction, easy workup, high yield, high purity of the products and an environment friendly approach. 相似文献
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Mahboob Alam Shahab A.A. Nami Ahmad Husain Dong-Ung Lee Soonheum Park 《Comptes Rendus Chimie》2013,16(3):201-206
The synthesis, spectral characterization, crystal structure and antimicrobial activity of the novel synthetic molecule 7a-Aza-B-homostigmast-5-eno [7a,7-d] tetrazole, C29H48N4 has been reported. The structure has also been determined by X-ray diffraction technique using direct method and was refined on F2 by the full-matrix least-squares. Crystals are orthorhombic and their space group is P212121, with a = 7.230(3), b = 31.451(13), c = 11.974(5) (Å), α = β = γ = 90°. It can be conveniently obtained by the reaction of 7-Oxostigmast-5-ene with hydrazoic acid. The molecule has also been screened for its possible in vitro antimicrobial activity against Staphylococcus aureus, Streptococcus mutans, Streptococcus pyogenes, Staphylococcus epidermidis, Bacillus cereus, Corynebacterium xerosis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa (MTCC 424). Minimum inhibitory concentration (MIC) of the synthesized compound has also been evaluated. The highest activity is observed against C. xerosi and P. vulgaris. Moreover, the compound has also been screened for its in vitro cytotoxicity against human colon carcinoma cell line, HCT116 and human liver hepatocellular carcinoma cell line, HepG2, using doxorubicin as standard. On the basis of its IC50 values, 7a-Aza-B-homostigmast-5-eno [7a,7-d] tetrazole was found to inhibit the cancer cells effectively. 相似文献
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Structural Chemistry - Toxoplasma gondii is an obligate intracellular protozoa that can infect a wide variety of warm-blooded animals and humans. It was claimed that novel anti-Toxoplasma gondii... 相似文献
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Afnan Ahmed ALGHAMDI Mohammad Mahboob ALAM Syed NAZREEN 《Turkish Journal of Chemistry》2020,44(4):1068
In the present work, a library of fifteen 2-hydroxy benzothiazole-linked 1,3,4 -oxadiazole derivatives have been synthesized and confirmed using different analytical techniques. All of the synthesized compounds have been tested for antibacterial and in silico pharmacokinetic studies for the first time. From the ADME predictions, compound 4 showed the highest in silico absorption percentage (86.77%), while most of the compounds showed more than 70% absorption. All of the compounds comply with the Lipinski rule of 5, suggesting that the compounds possess good drug likeness properties upon administration. Furthermore, all of the compounds follow the Veber rule, indicating good bioavailability and good intestinal absorption. The antibacterial results exhibited excellent to moderate activity. Compounds 5 , 9 , 12 , 14 , 15 , 16 , and 17 were the most active compounds against the tested bacterial strains. Compound 14 showed comparable MIC 6.25 ±0.2 μg/disc to the standard drug amoxicillin against the tested Gram-positive bacterial strains. Compounds 5 , 14 , 17 exhibited MIC 12.5 ±0.8 μg/disc, which was comparable to the standard drug against E. faecalis . It can be concluded that the synthesized compound could be used as a lead molecule in the development of new antibacterial agents with high efficacy. 相似文献
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