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51.
Tony Tite Vassilios Myrianthopoulos Emmanuel Mikros Roxane Tenta Tzortzis Nomikos 《Tetrahedron》2010,66(50):9620-9628
A number of new pyrazolo[3,4-c] and [4,3-b]pyridine C-nucleosides, which can be viewed as 4- or 6-deazaformycin analogues were synthesized and examined as potential adenosine deaminase (ADA) inhibitors. The compounds were prepared through the condensation of a suitably substituted, lithiated 2- or 4-methylpyridine with tri-O-benzyl-d-ribonolactone, followed by borohydride reduction of the resulting hemiacetals, intramolecular Mitsunobu cyclisation of the derived diols, formation of the pyrazolopyridine ring system and subsequent removal of the protecting groups. These derivatives were designed on the structural basis provided by docking simulations performed within the enzyme catalytic site, however they demonstrated weak ADA inhibitory activity. Theoretical calculations assisted in the interpretation of the obtained biological data, thus providing guidance for rational structural modifications within this molecular scaffold. 相似文献
52.
Using molecular dynamics simulations, we investigate the oscillatory behaviors of carbon nanotube oscillators containing sp3-hybridized defects formed by hydrogen chemisorption. It is found that the presence of these defects significantly affects the kinetic and potential energies of the nanotube systems, which in turn affects their oscillation periods and frequencies. We have also studied the oscillatory characteristics of the oscillators containing sp3-hybridized Stone-Wales defects. Our results show that it is possible to control the motion of the inner nanotube by introducing sp3-hybridized defects on the outer nanotube, which provides a potential way to tune the oscillatory behavior of nanotube oscillators. 相似文献
53.
The nature of the future is completely different from the nature of the past. When quantum effects are significant, the future
shows all the signs of quantum weirdness, including duality, uncertainty, and entanglement. With the passage of time, after
the time-irreversible process of state-vector reduction has taken place, the past emerges, with the previous quantum uncertainty
replaced by the classical certainty of definite particle identities and states. The present time is where this transition
largely takes place, but the process does not take place uniformly: evidence from delayed choice and related experiments shows
that isolated patches of quantum indeterminacy remain, and that their transition from probability to certainty only takes
place later. Thus, when quantum effects are significant, the picture of a classical Evolving Block Universe (‘EBU’) cedes
place to one of a Crystallizing Block Universe (‘CBU’), which reflects this quantum transition from indeterminacy to certainty,
while nevertheless resembling the EBU on large enough scales. 相似文献
54.
Ho Tony; Martinez-Moreno Juan; Peralta Antonio M.; Russo Bernard 《Journal London Mathematical Society》2002,65(1):85-102
At the regional conference held at the University of California,Irvine, in 1985 [24], Harald Upmeier posed three basic questionsregarding derivations on JB*-triples: (1) Are derivations automatically bounded? (2) When are all bounded derivations inner? (3) Can bounded derivations be approximated by inner derivations? These three questions had all been answered in the binary cases.Question 1 was answered affirmatively by Sakai [17] for C*-algebrasand by Upmeier [23] for JB-algebras. Question 2 was answeredby Sakai [18] and Kadison [12] for von Neumann algebras andby Upmeier [23] for JW-algebras. Question 3 was answered byUpmeier [23] for JB-algebras, and it follows trivially fromthe KadisonSakai answer to question 2 in the case ofC*-algebras. In the ternary case, both question 1 and question 3 were answeredby Barton and Friedman in [3] for complex JB*-triples. In thispaper, we consider question 2 for real and complex JBW*-triplesand question 1 and question 3 for real JB*-triples. A real orcomplex JB*-triple is said to have the inner derivation propertyif every derivation on it is inner. By pure algebra, every finite-dimensionalJB*-triple has the inner derivation property. Our main results,Theorems 2, 3 and 4 and Corollaries 2 and 3 determine whichof the infinite-dimensional real or complex Cartan factors havethe inner derivation property. 相似文献
55.
We report the generation and coherent detection of freely propagating ultrashort baseband electromagnetic pulses. Using optical rectification in ?110? GaAs for wideband emission and electro-optic sampling in a poled polymer for wideband detection, we demonstrate spectral sensitivity that extends from the far infrared (lambda~100 mum) to ~33 THz(lambda = 9 mum) . Over a band of nearly 20 THz, a relatively flat frequency response is observed. We discuss issues that limit the response bandwidth. 相似文献
56.
AN INVARIANT FOR HYPERGRAPHS 总被引:11,自引:0,他引:11
ANINVARIANTFORHYPERGRAPHSWANGJIANFANG(InstituteofAPPliedMathematics,ChineseAcademyofSciences,Beijing100080,ChinaandAsia-Pacif... 相似文献
57.
Tony T Lee 《Journal of Combinatorial Theory, Series A》1981,31(2):136-145
A partial ordering is defined for monotone projections f: N → N, N = {1, 2,…, n}, such that the class of these mappings is a lattice which is isomorphic to the partition lattice. Thus a partition can be uniquely represented by an element of this class of mappings and the partial ordering of partitions is preserved. Algorithms for computing the join and meet of given partitions are presented. 相似文献
58.
59.
Poly-N-acetyllactosamine oligomer is a type-2 glycan core from which a number of important bioactive glycoconjugates are assembled in vivo. Development of an effective synthesis of N-acetyllactosamine oligomers will therefore provide a new chemoenzymatic entry to this class of complex saccharides. This paper describes the design and synthesis of thioglycoside building blocks, determination of their relative reactivity values, and demonstration of their use in the programmable one-pot synthesis of various N-acetyllactosamine oligomers. Through a combination of segment condensation, the strategy allows for the preparation of larger oligosaccharides with minimal protecting group manipulation, as illustrated in the synthesis of an octasaccharide in a very short period of time. 相似文献
60.
N-Acyloxy-N-alkoxyamides are anomeric amides that are direct-acting mutagens. They have been shown to damage DNA in the major and the minor grooves in a pH and sequence-selective manner. In acidic media, they damage adenines at N3 in the minor groove but above neutral pH, only guanine is damaged at N7 in the major groove. Both the acyloxy leaving group and the alkoxy group at the amide nitrogen are responsible for their electrophilicity and Salmonella mutagenicities in TA 100 and DNA damage data confirm that the mutagens react with DNA in an intact form, rather than by solvolysis to electrophilic nitrenium ions in the cytosol, or in vitro, prior to reacting with DNA. Hydrophobicity plays a role in both mutagenicity and DNA damage. 相似文献