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991.
Yijing Wu Wenjun Zheng Canrong Chen Linyan Yang Ping Tong Yanhui Zhong Zian Lin Zongwei Cai 《Journal of separation science》2023,46(22):2300482
Here, an imine-linked-based spherical covalent organic framework (COF) was prepared at room temperature. The as-synthesized spherical COF served as an adsorbent in dispersive solid-phase extraction (dSPE), by its virtue of great surface area (1542.68 m2/g), regular distribution of pore size (2.95 nm), and excellent stability. Therefore, a simple and high-efficiency dispersive solid phase extraction method based on a spherical COF coupled with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established to determine aryl organophosphate esters in biological samples. This approach displayed favorable linearity in the range of 10.0–1000.0 ng/L (r > 0.9989), a high signal enhancement factor (58.8–181.8 folds) with low limits of detection (0.3–3.3 ng/L). Moreover, it could effectively eliminate complex matrix interference to accurately extract seven aryl organophosphate esters from mouse serum and tissue samples with spiked recoveries of 82.0%–117.4%. The as-synthesized spherical COF has been successfully applied in sample preparation. The dSPE-HPLC-MS/MS method based on a spherical COF has potential application to study the pollutants' metabolism in vivo. 相似文献
992.
Liqun Fang Mengyi Wen Yanfang Zou Chu Chu Chunyan Wu Shengqiang Tong 《Journal of separation science》2023,46(22):2300570
Polymethoxyflavones were a unique class of natural and safe flavonoids containing two or more methoxy groups, which were also the most abundant edible part in Citrus peel. The optimum condition in the process of selective extraction of polymethoxylated flavones from Citrus peel by matrix solid-phase dispersion (MSPD) was as follows: SBA-15 as adsorbent, ethyl acetate as eluent, the mass ratio of adsorbent to sample 1:1, and the mixture of sample and adsorbent was ground for 3 min. Twelve antioxidants were successfully screened by micro-fractionation bioactivity evaluation assay, in which four of them were flavonoid glycosides, seven of them were polymethoxylated flavones, and one was phenylpropanoid. 1-sinapoly-β-D-glucopyranoside (1) was reported for the first time in Citrus peel. And antioxidant capacity of 1-sinapoly-β-D-glucopyranoside, 5, 7, 8, 3′, 4′, 5′-hexamethoxyflavone (6), hexamethoxyflavone (11), and 5, 6, 7, 4′-tetramethoxyflavone (7) were reported for the first time. Nobiletin (compound 8), 3, 5, 6, 7, 8, 3′, 4′-heptamethoxyflavone (9) and tangeretin (10) were isolated and purified by countercurrent chromatography combined with preparative liquid chromatography. Antioxidant activity evaluation indicated that the three isolated polymethoxylated flavones owned similar antioxidant activity. This study indicated that MSPD combined with micro-fractionation bioactive evaluation was efficient in screening bioactive compounds for rapid extraction and effective pinpointing bioactive substances in natural products. 相似文献
993.
994.
Di Hu Dr. Yungen Liu Dr. Yau‐Tsz Lai Ka‐Chung Tong Dr. Yi‐Man Fung Dr. Chun‐Nam Lok Prof. Dr. Chi‐Ming Che 《Angewandte Chemie (International ed. in English)》2016,55(4):1387-1391
Identification of the molecular target(s) of anticancer metal complexes is a formidable challenge since most of them are unstable toward ligand exchange reaction(s) or biological reduction under physiological conditions. Gold(III) meso‐tetraphenylporphyrin ( gold‐1 a ) is notable for its high stability in biological milieux and potent in vitro and in vivo anticancer activities. Herein, extensive chemical biology approaches employing photo‐affinity labeling, click chemistry, chemical proteomics, cellular thermal shift, saturation‐transfer difference NMR, protein fluorescence quenching, and protein chaperone assays were used to provide compelling evidence that heat‐shock protein 60 (Hsp60), a mitochondrial chaperone and potential anticancer target, is a direct target of gold‐1 a in vitro and in cells. Structure–activity studies with a panel of non‐porphyrin gold(III) complexes and other metalloporphyrins revealed that Hsp60 inhibition is specifically dependent on both the gold(III) ion and the porphyrin ligand. 相似文献
995.
Shihong Tong 《International Journal of Theoretical Physics》2016,55(2):854-860
By using dimensional reduction and consistent anomaly method, we calculate the Hawking flux of the spin- 3/2 field in the Kerr black hole background. The results confirm that the Hawking radiation doesn’t depends on the detail of the fields living near the horizon, at least at the semi-classical level. The Hawking temperature is an universality character of black hole which only depends on the information of the horizon. Our calculation agrees with earlier results obtained by the WKB/tunneling method (Yale and Mann, Phys. Lett. B 673(2), 168–172, 2009). 相似文献
996.
997.
Mi-Hyun Lee Bhari Mallanna Nagaraja Prakash Natarajan Ngoc Thanh Truong Kwan Young Lee Sungho Yoon Kwang-Deog Jung 《Research on Chemical Intermediates》2016,42(1):123-140
PtSn/θ-Al2O3 catalysts with different amounts of K (0.14, 0.22, 0.49, 0.72, and 0.96 wt%) are prepared to investigate the K effects on the PtSn catalyst in propane dehydrogenation (PDH). KPtSn catalyst with 0.xx wt% K, 0.5 wt% Pt and 0.75 wt% Sn is designated as xx-KPtSn. PDH was performed at 873 K and a gas hourly space velocity (GHSV) of 53,000 mL/gcat h. The temperature-programmed desorption (NH3-TPD), temperature-programmed reduction (TPR) and CO chemisorption of the KPtSn catalysts with K added revealed the potassium addition blocked the acid sites, promoted the reduction of Sn oxide and decreased the Pt dispersion. The formations of cracking products and higher hydrocarbons on acid sites were suppressed by the K effect of blocking the acid sites. In contrast, K addition at more than 0.72 wt% rather increased cracking products and the amount of coke, resulting in the severe deactivation of catalysts. The high cracking products on the KPtSn catalysts with the high amount of K should not be related to the acid sites, because the acid sites were monotonously decreased with an increase in the amount of K. Instead, the potassium affected the characteristics of PtSn. The interaction between Pt and Sn could be weakened by enriching the reduced Sn, because the K component promoted the reduction of Sn oxide in the TPR experiments. Therefore, the 14-KPtSn catalyst with the low amount of K exhibits the highest stability and selectivity among the prepared KPtSn catalysts due to the compromise of the advantageous (blocking the acid sites) and bad (weakening the interaction between Pt and Sn) effects of the K addition in PDH. 相似文献
998.
Construction of Mononuclear Copper(II) and Trinuclear Cobalt(II) Complexes Based on Asymmetric Salamo‐Type Ligands
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Wen‐Kui Dong Jin‐Tong Zhang Yin‐Juan Dong Yang Zhang Zheng‐Kun Wang 《无机化学与普通化学杂志》2016,642(2):189-196
Mononuclear copper(II) and trinuclear cobalt(II) complexes, namely [Cu(L1)]2 · CH2Cl2 and [{Co(L2)(EtOH)}2Co(H2O)] · EtOH {H2L1 = 4,6‐dichloro‐6′‐methyoxy‐2,2′‐[1,1′‐(ethylenedioxydinitrilo)dimethylidyne]diphenol and H3L2 = 6‐ethyoxy‐6′‐hydroxy‐2,2′‐[1,1′‐(ethylenedioxydinitrilo)dimethylidyne]diphenol}, were synthesized and characterized by elemental analyses, IR and UV/Vis spectroscopy, and single‐crystal X‐ray diffraction. In the CuII complex, the CuII atom is four‐coordinate, with a N2O2 coordination sphere, and has a slightly distorted square‐planar arrangement. Interestingly, the obtained trinuclear CoII complex is different from the common reported 2:3 (L:CoII) salamo‐type CoII complexes. Infinite 2D layer supramolecular structures are formed via abundant intermolecular hydrogen bonding and π ··· π stacking interactions in the CuII and CoII complexes. 相似文献
999.
A new phthalide derivative named calocephalactone was isolated from the root of Leontopodium calocephalum. Its structure was elucidated by means of spectroscopic methods, including HRESIMS, IR, 1D and 2D NMR. We also evaluated its the antibacterial experiment, calocephalactone ( 1 ) did not show obvious antibacterial activity. 相似文献
1000.
Dan Wang Yong Sun Zheng Tong Qian Yang Lili Chang Xueru Meng Limin Wang Weimin Tian Xuchu Wang 《Electrophoresis》2016,37(22):2930-2939
The extraction of high‐purity proteins from the washing solution (WS) of rubber particles (also termed latex‐producing organelles) from laticifer cells in rubber tree for proteomic analysis is challenging due to the low concentration of proteins in the WS. Recent studies have revealed that proteins in the WS might play crucial roles in natural rubber biosynthesis. To further examine the involvement of these proteins in natural rubber biosynthesis, we designed an efficiency method to extract high‐purity WS proteins. We improved our current borax and phenol‐based method by adding reextraction steps with phenol (REP) to improve the yield from low protein concentration samples. With this new method, we extracted WS proteins that were suitable for proteomics. Indeed, compared to the original borax and phenol‐based method, the REP method improved both the quality and quantity of isolated proteins. By repeatedly extracting from low protein concentration solutions using the same small amount of phenol, the REP method yielded enough protein of sufficiently high‐quality from starting samples containing less than 0.02 mg of proteins per milliliter. This method was successfully applied to extract the rubber particle proteins from the WS of natural rubber latex samples. The REP‐extracted WS proteins were resolved by 2DE, and 28 proteins were positively identified by MS. This method has the potential to become widely used for the extraction of proteins from low protein concentration solutions for proteomic analysis. 相似文献