Surface adsorption and vesicle formation of dilauroylphosphatidylcholine in room temperature ionic liquids

In this work, we study the adhesion forces between atomic force microscopy (AFM) tips and superficial dentin etched with phosphoric acid. Initially, we quantitatively analyze the effect of acid etching on the surface heterogeneity and the surface roughness, two parameters that play a key role in the adhesion phenomenon. From a statistical study of the force-distance curves, we determine the average adhesion forces on the processed substrates. Our results show that the average adhesion forces, measured in water, increase linearly with the acid exposure time. The highest values of such forces are ascribed to the high density of collagen fibers on the etched surfaces. The individual contribution of exposed collagen fibrils to the adhesion force is highlighted. We also discuss in this paper the influence of the environmental medium (water/air) in the adhesion measurements. We show that the weak forces involved require working in the aqueous medium.     

Determination of Intermolecular Acetyl Distribution of Cellulose Triacetate by Reversed Phase High Performance Liquid Chromatography

The chromatographic method for the determination of the intermolecular acetyl distribution of cellulose triacetate (CTA) was established; the key point of the method is a gradient elution by gradually changing the solvent composition of the ternary mixture of chloroform, methanol, and water on a phenyl-bonded silica gel stationary phase. A positive correlation between the retention time and the degree of acetyl substitution was observed under the established chromatographic conditions. The validity of the elution peak width as the measure of intermolecular acetyl distribution was confirmed by the co-injection and fractionation experiments and the comparison of a peak width with a statistically estimated distribution.     

Whitening as a Tool for Estimating Mutual Information in Spatiotemporal Data Sets

We address the issue of inferring the connectivity structure of spatially extended dynamical systems by estimation of mutual information between pairs of sites. The well-known problems resulting from correlations within and between the time series are addressed by explicit temporal and spatial modelling steps which aim at approximately removing all spatial and temporal correlations, i.e. at whitening the data, such that it is replaced by spatiotemporal innovations; this approach provides a link to the maximum-likelihood method and, for appropriately chosen models, removes the problem of estimating probability distributions of unknown, possibly complicated shape. A parsimonious multivariate autoregressive model based on nearest-neighbour interactions is employed. Mutual information can be reinterpreted in the framework of dynamical model comparison (i.e. likelihood ratio testing), since it is shown to be equivalent to the difference of the log-likelihoods of coupled and uncoupled models for a pair of sites, and a parametric estimator of mutual information can be derived. We also discuss, within the framework of model comparison, the relationship between the coefficient of linear correlation and mutual information. The practical application of this methodology is demonstrated for simulated multivariate time series generated by a stochastic coupled-map lattice. The parsimonious modelling approach is compared to general multivariate autoregressive modelling and to Independent Component Analysis (ICA).     

Aggregating pattern dynamics in a chemotaxis model including growth

A population model including diffusion, chemotaxis and growth is studied. Assuming that the diffusion rate and the chemotactic rate are both very small compared with the growth rate, we derive a new equation to describe the time-evolution of the aggregating region of biological individuals and show the conditions for the existence and stability of radially symmetric equilibrium solutions of the equation, which indicate the aggregation of individuals.     

Synthesis of unsymmetrically substituted 2,5-piperazinediones: regioselective alkylation of piperazinedione derivatives

A variety of unsymmetrically substituted 2,5-piperazinediones have been synthesized by regioselective alkylation of piperazinedione derivatives.     

Long range scattering for nonlinear Schrödinger equations in one space dimension

We consider the scattering problem for the nonlinear Schrödinger equation in 1+1 dimensions: where = /x,R{0},R,p>3. We show that modified wave operators for (*) exist on a dense set of a neighborhood of zero in the Lebesgue spaceL ²(R) or in the Sobolev spaceH ¹(R)., The modified wave operators are introduced in order to control the long range nonlinearity |u|² u.Laboratoire associé au Centre National de la Recherche Scientifique     

Nonlinear scattering with nonlocal interaction

We consider the scattering problem for the Hartree type equation in ⁿ withn2:

Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3

Amphidinol 3 (AM3) is a marine natural product produced by the dinoflagellate Amphidinium klebsii. Although the absolute configuration of AM3 was determined in 1999 by extensive NMR analysis and degradation of the natural product, it was a daunting task because of the presence of numerous stereogenic centers on the acyclic carbon chain and the limited availability from natural sources. Thereafter, revisions of the absolute configurations at C2 and C51 were reported in 2008 and 2013, respectively. Reported herein is the revised absolute configuration of AM3: 32S, 33R, 34S, 35S, 36S, and 38S based on the chemical synthesis of partial structures corresponding to the C31–C67 fragment of AM3 in combination with degradation of the natural product. The revised structure is unique in that both antipodal tetrahydropyran counterparts exist on a single carbon chain. The structural revision of AM3 may affect proposed structures of congeners related to the amphidinols.     

Preparation of cruciferous phytoalexin related metabolites, (−)-dioxibrassinin and (−)-3-cyanomethyl-3-hydroxyoxindole, and determination of their absolute configurations by vibrational circular dichroism (VCD)

Cruciferous phytoalexin related metabolites, (−)-dioxibrassinin (1) and (−)-3-cyanomethyl-3-hydroxyoxindole (2) were prepared from isatin as racemates and were resolved by chiral HPLC. Their absolute configurations were determined by the new chiroptical technique, vibrational circular dichroism (VCD), as well as by the conventional electronic circular dichroism (ECD). It is concluded that the absolute configurations of the naturally occurring (−)-1 and (−)-2 are both S.     

Synthetic approaches toward mitomycins. I. Stereoselective synthesis of a tetracyclic intermediate.

A highly efficient synthesis of a tetracyclic intermediate to the antitumor antibiotics AX-2 , mitomycin A , and C is described.