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Dr. Louis P. Conway Dr. Veronica Rendo M. Sc. Mário S. P. Correia Prof. Dr. Ingvar A. Bergdahl Prof. Dr. Tobias Sjöblom Prof. Dr. Daniel Globisch 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(34):14448-14452
N-Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines. Herein, we demonstrate that the human arylamine N-acetyltransferase NAT2 also acetylates aliphatic endogenous amines. Metabolomic analysis and chemical synthesis revealed increased intracellular concentrations of mono- and diacetylated spermidine in human cell lines expressing the rapid compared to the slow acetylator NAT2 phenotype. The regioselective N8-acetylation of monoacetylated spermidine by NAT2 answers the long-standing question of the source of diacetylspermidine. We also identified selective acetylation of structurally diverse alkylamine-containing drugs by NAT2, which may contribute to variations in patient responses. The results demonstrate a previously unknown functionality and potential regulatory role for NAT2, and we suggest that this enzyme should be considered for re-classification. 相似文献
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Konarovskyi Vitalii Lehmann Tobias von Renesse Max 《Journal of statistical physics》2020,178(3):666-681
Journal of Statistical Physics - We consider the Dean–Kawasaki equation with smooth drift interaction potential and show that measure-valued solutions exist only in certain parameter regimes... 相似文献
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Sebastian Fichter Sebastian Kaufmann Dr. Peter Kaden Dr. Tobias S. Brunner Prof. Dr. Thorsten Stumpf Prof. Dr. Peter W. Roesky Dr. Juliane März 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(41):8867-8870
The synthesis of a tetravalent neptunium amidinate [NpCl((S)-PEBA)3] ( 1 ) ((S)-PEBA=(S,S)-N,N′-bis-(1-phenylethyl)-benzamidinate) is reported. This complex represents the first structurally characterized enantiopure transuranic compound. Reactivity studies with halide/pseudohalides yielding [NpX((S)-PEBA)3] (X=F ( 2 ), Br ( 3 ), N3 ( 4 )) have shown that the chirality-at-metal is preserved for all compounds in the solid state. Furthermore, they represent an unprecedented example of a structurally characterized metal–organic Np complex featuring a Np−Br ( 3 ) bond. In addition, 4 is the only reported tetravalent transuranic azide. All compounds were additionally characterized in solution using para-magnetic NMR spectroscopy showing an expected C3-symmetry at low temperatures. 相似文献
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DNA microarrays, or "DNA chips", represent a relatively new technology that is having a profound impact on biology and medicine, yet analytical research into this area is somewhat sparse. This article presents an overview of DNA microarrays and their application to gene expression analysis from the perspective of analytical chemistry, treating aspects of array platforms, measurement, image analysis, experimental design, normalization, and data analysis. Typical approaches are described and unresolved issues are discussed, with a view to identifying some of the contributions that might be made by analytical chemists. 相似文献
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