全文获取类型
收费全文 | 2382篇 |
免费 | 191篇 |
国内免费 | 6篇 |
专业分类
化学 | 1816篇 |
晶体学 | 11篇 |
力学 | 47篇 |
数学 | 309篇 |
物理学 | 396篇 |
出版年
2023年 | 39篇 |
2022年 | 49篇 |
2021年 | 76篇 |
2020年 | 130篇 |
2019年 | 109篇 |
2018年 | 46篇 |
2017年 | 47篇 |
2016年 | 155篇 |
2015年 | 123篇 |
2014年 | 118篇 |
2013年 | 143篇 |
2012年 | 167篇 |
2011年 | 223篇 |
2010年 | 118篇 |
2009年 | 86篇 |
2008年 | 149篇 |
2007年 | 140篇 |
2006年 | 114篇 |
2005年 | 120篇 |
2004年 | 90篇 |
2003年 | 55篇 |
2002年 | 58篇 |
2001年 | 19篇 |
2000年 | 23篇 |
1999年 | 16篇 |
1998年 | 12篇 |
1997年 | 6篇 |
1996年 | 11篇 |
1995年 | 7篇 |
1994年 | 12篇 |
1993年 | 7篇 |
1992年 | 6篇 |
1991年 | 8篇 |
1990年 | 3篇 |
1989年 | 6篇 |
1987年 | 6篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1978年 | 3篇 |
1976年 | 5篇 |
1968年 | 2篇 |
1967年 | 7篇 |
1966年 | 4篇 |
1964年 | 2篇 |
1962年 | 2篇 |
1920年 | 2篇 |
1906年 | 2篇 |
排序方式: 共有2579条查询结果,搜索用时 31 毫秒
61.
62.
63.
64.
Tobias Kaiser 《Israel Journal of Mathematics》2016,212(1):139-162
We show that a globally subanalytic function that is real analytic can be extended in a globally subanalytic way to a holomorphic function. We also establish a parametric version of this result. For other important ominimal structures, we show that unary definable real analytic functions can be extended definably to a holomorphic function. 相似文献
65.
66.
67.
Orlova M. A. Nikolaev A. L. Trofimova T. P. Severin A. V. Gopin A. V. Zolotova N. S. Dolgova V. K. Orlov A. P. 《Russian Chemical Bulletin》2019,68(5):1102-1108
Russian Chemical Bulletin - Modification of the cocrystallization method for producing hydroxyapatite (HAP) and an HAP-Cu combination to the enzymatic method using alkaline phosphatase leads to a... 相似文献
68.
Dr. Anna Notaro Marta Jakubaszek Severin Koch Dr. Riccardo Rubbiani Dr. Orsolya Dömötör Dr. Éva A. Enyedy Mazzarine Dotou Dr. Fethi Bedioui Mickaël Tharaud Dr. Bruno Goud PD Dr. Stefano Ferrari Prof. Dr. Enzo Alessio Dr. Gilles Gasser 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(22):4997-5009
Cancer is one of the main causes of death worldwide. Chemotherapy, despite its severe side effects, is to date one of the leading strategies against cancer. Metal-based drugs present several potential advantages when compared to organic compounds and they have gained trust from the scientific community after the approval on the market of the drug cisplatin. Recently, we reported the ruthenium complex ([Ru(DIP)2(sq)](PF6) (where DIP is 4,7-diphenyl-1,10-phenantroline and sq is semiquinonate) with a remarkable potential as chemotherapeutic agent against cancer, both in vitro and in vivo. In this work, we analyse a structurally similar compound, namely [Ru(DIP)2(mal)](PF6), carrying the flavour-enhancing agent approved by the FDA, maltol (mal). To possess an FDA approved ligand is crucial for a complex, whose mechanism of action might include ligand exchange. Herein, we describe the synthesis and characterisation of [Ru(DIP)2(mal)](PF6), its stability in solutions and under conditions that resemble the physiological ones, and its in-depth biological investigation. Cytotoxicity tests on different cell lines in 2D model and on HeLa MultiCellular Tumour Spheroids (MCTS) demonstrated that our compound has higher activity than cisplatin, inspiring further tests. [Ru(DIP)2(mal)](PF6) was efficiently internalised by HeLa cells through a passive transport mechanism and severely affected the mitochondrial metabolism. 相似文献
69.
70.
Lukas M. Müller-Wirtz Daniel Kiefer Joschua Knauf Maximilian A. Floss Jonas Doneit Beate Wolf Felix Maurer Daniel I. Sessler Thomas Volk Sascha Kreuer Tobias Fink 《Molecules (Basel, Switzerland)》2021,26(9)
High inspired oxygen during mechanical ventilation may influence the exhalation of the previously proposed breath biomarkers pentanal and hexanal, and additionally induce systemic inflammation. We therefore investigated the effect of various concentrations of inspired oxygen on pentanal and hexanal exhalation and serum interleukin concentrations in 30 Sprague Dawley rats mechanically ventilated with 30, 60, or 93% inspired oxygen for 12 h. Pentanal exhalation did not differ as a function of inspired oxygen but increased by an average of 0.4 (95%CI: 0.3; 0.5) ppb per hour, with concentrations doubling from 3.8 (IQR: 2.8; 5.1) ppb at baseline to 7.3 (IQR: 5.0; 10.8) ppb after 12 h. Hexanal exhalation was slightly higher at 93% of inspired oxygen with an average difference of 0.09 (95%CI: 0.002; 0.172) ppb compared to 30%. Serum IL-6 did not differ by inspired oxygen, whereas IL-10 at 60% and 93% of inspired oxygen was greater than with 30%. Both interleukins increased over 12 h of mechanical ventilation at all oxygen concentrations. Mechanical ventilation at high inspired oxygen promotes pulmonary lipid peroxidation and systemic inflammation. However, the response of pentanal and hexanal exhalation varies, with pentanal increasing by mechanical ventilation, whereas hexanal increases by high inspired oxygen concentrations. 相似文献