Antibacterial, Anti-Chlamydial, and Cytotoxic Activities of a Marine Snail (Hexaplex trunculus) Phospholipase A2: an In Vitro Study

In order to report pharmacological characterization of marine snail (Hexaplex trunculus) hepatopancreatic phospholipase A₂ (mSDPLA₂), we have talked for the first time the antimicrobial activity against different pathogenic bacterial strains, anti-chlamydial activity as well as its cytotoxic activity against McCoy cell lines. mSDPLA₂, showed a high level of activity towards Gram-positive bacteria as Staphylococcus aureus and Staphylococcus epidermidis. Whereas Gram-negative bacteria, unfortunately, exhibited a higher resistance, mSDPLA₂ was also found to have a strong cytotoxic activity, causing significant morphological alterations of the McCoy cell lines surfaces and to be a hinder to the proliferation. Moreover, mSDPLA₂ proved to have a very potent anti-chlamydial activity. Over 95?% inhibition of chlamydial inclusions were obtained at a concentration of 10???g/ml of mSDPLA₂ after 24?h postinfection. Interestingly, at a concentration of 10???g/ml of mSDPLA₂, the proliferation of McCoy cells was not affected. Approximately 50?% inhibition of cell growth was obtained with a concentration of 37???g/mL of mSDPLA₂. mSDPLA₂ could be considered as an excellent candidate for the development of a new anti-infective agent. This enzyme showed significant antimicrobial activities.     

Thermodynamic analysis of MHD Couette–Poiseuille flow of water-based nanofluids in a rotating channel with radiation and Hall effects

Journal of Thermal Analysis and Calorimetry - This study will focus on the first- and second-law analyses of MHD Couette–Poiseuille flow of water-based nanofluids in a rotating permeable...     

Dealing with external actions in belief causal networks

Graphical models are efficient and simple ways to represent dependencies between variables. We introduce in this paper the so-called belief causal networks where dependencies are uncertain causal links and where the uncertainty is represented by belief masses. Through these networks, we propose to represent the results of passively observing the spontaneous behavior of the system and also evaluate the effects of external actions. Interventions are very useful for representing causal relations, we propose to compute their effects using a generalization of the “do” operator. Even if the belief chain rule is different from the Bayesian chain rule, we show that the joint distributions of the altered structures to graphically describe interventions are equivalent. This paper also addresses new issues that are arisen when handling interventions: we argue that in real world applications, external manipulations may be imprecise and show that they have a natural encoding under the belief function framework.     

Visible‐Light‐Mediated Metal‐Free Synthesis of Trifluoromethylselenolated Arenes

The first visible‐light‐mediated synthesis of trifluoromethylselenolated arenes under metal‐free conditions is reported. The use of an organic photocatalyst enables the trifluoromethylselenolation of arene diazonium salts using the shelf‐stable reagent trifluoromethyl tolueneselenosulfonate at room temperature. The reaction does not require the presence of any additives and shows high functional‐group tolerance, covering a very broad range of starting materials. Mechanistic investigations, including EPR spectroscopy, luminescence investigations, and cyclic voltammetry allow rationalization of the reaction mechanism.     

Regioselective remote CH fluoroalkylselenolation of 8-aminoquinolines

Herein, the direct C-5 fluoroalkylselenolation of 8-aminoquinolines is described. The Pd-catalyzed reaction is performed with the in situ generated fluoroalkylselenyl chloride and various 8-aminoquinoline amides or sulfonamides. The desired products were formed in moderate to excellent yields.     

Synthesis and Antimicrobial Activity of New 1,2,3‐Triazolopyrimidine Derivatives and Their Glycoside and Acyclic Nucleoside Analogs

New [1,2,4‐oxadiazolyl]methyl‐3H‐[1,2,3]triazolo[4,5‐d]pyrimidin derivatives were synthesized starting from N′‐Hydroxy‐1‐naphthimidamide. The N‐substituted acyclic nucleoside analogs as well as the substituted glycosides were also prepared by reaction with the corresponding reagents. The antimicrobial results indicated that most of the tested compounds exhibited moderate to high antimicrobial activity whereas few compounds were found to exhibit little or no activity against the tested microorganisms.     

The experimental/numerical investigation of variations in strip speed,water shower pattern and water temperature on high-temperature strip cooling rate in hot strip mill

Journal of Thermal Analysis and Calorimetry - Hot-rolled strips are cooled on the run-out table to achieve the customer-required mechanical properties. Cooling reduces the oxidation, which can...