全文获取类型
收费全文 | 1858篇 |
免费 | 30篇 |
国内免费 | 8篇 |
专业分类
化学 | 1146篇 |
晶体学 | 6篇 |
力学 | 59篇 |
数学 | 237篇 |
物理学 | 448篇 |
出版年
2022年 | 26篇 |
2021年 | 38篇 |
2020年 | 32篇 |
2019年 | 21篇 |
2018年 | 20篇 |
2017年 | 15篇 |
2016年 | 46篇 |
2015年 | 23篇 |
2014年 | 35篇 |
2013年 | 98篇 |
2012年 | 81篇 |
2011年 | 103篇 |
2010年 | 64篇 |
2009年 | 47篇 |
2008年 | 120篇 |
2007年 | 109篇 |
2006年 | 96篇 |
2005年 | 99篇 |
2004年 | 64篇 |
2003年 | 52篇 |
2002年 | 59篇 |
2001年 | 41篇 |
2000年 | 29篇 |
1999年 | 31篇 |
1998年 | 26篇 |
1997年 | 39篇 |
1996年 | 32篇 |
1995年 | 29篇 |
1994年 | 33篇 |
1993年 | 29篇 |
1992年 | 35篇 |
1991年 | 16篇 |
1990年 | 14篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 26篇 |
1984年 | 20篇 |
1983年 | 18篇 |
1982年 | 21篇 |
1981年 | 22篇 |
1980年 | 12篇 |
1979年 | 14篇 |
1977年 | 11篇 |
1976年 | 13篇 |
1975年 | 15篇 |
1974年 | 10篇 |
1973年 | 12篇 |
1970年 | 9篇 |
排序方式: 共有1896条查询结果,搜索用时 15 毫秒
81.
Luisa Pieroni Federica Iavarone Alessandra Olianas Viviana Greco Claudia Desiderio Claudia Martelli Barbara Manconi Maria Teresa Sanna Irene Messana Massimo Castagnola Tiziana Cabras 《Journal of separation science》2020,43(1):313-336
More than 300 different protein post‐translational modifications are currently known, but only a few have been extensively investigated because modified proteoforms are commonly present in sub‐stoichiometry amount. For this reason, improvement of specific enrichment techniques is particularly useful for the proteomic characterization of post‐translationally modified proteins. Enrichment proteomic strategies could help the researcher in the challenging issue to decipher the complex molecular cross‐talk existing between the different factors influencing the cellular pathways. In this review the state of art of the platforms applied for the enrichment of specific and most common post‐translational modifications, such as glycosylation and glycation, phosphorylation, sulfation, redox modifications (i.e. sulfydration and nitrosylation), methylation, acetylation, and ubiquitinylation, are described. Enrichments strategies applied to characterize less studied post‐translational modifications are also briefly discussed. 相似文献
82.
High resolution gas chromatography (HRGC) coupled to a “purge and trap” extraction-injection technique is described as a method of determining 1,2,4-trichlorobenzene in water at levels as low as parts-per-trillion (ppt). In order to investigate the interference from other volatile organic compounds (VOCs) several detection systems were compared: flame ionization, electron capture, and mass spectrometry-multiple ion detection. Concentrations ranging from 15 to 600 ng/L were analyzed in 20 ml standard aqueous solutions. The mean accuracy of the method varied from 89 to 103%, and its mean precision varied from ± 0.85 to ± 7.5 % for all detectors. The detection limits were 20 ng/L for FID, 2 ng/L for ECD and 0.5 ng/L for MID-MS detectors. The procedure was successfully applied to the analysis of industrial waste waters. The necessity of an appropriate internal standard to improve the quantitative determination and to determine possible losses or degradation of 1,2,4-trichlorobenzene during handling or storage is discussed. 相似文献
83.
Nativitat Valls Josep Bonjoch Carlos Del Alamo Joan Bosch 《Helvetica chimica acta》1992,75(1):137-144
A stereodivergent synthesis of enantiomerically pure E-nor-15-azayohimbines via condensation of tryptamine with derivatives of pyroglutamate 4 is reported. When the Pictet-Spengler reaction was induced in refluxing aqueous AcOH a nearly equimolar ratio of lactams 7 and 8 was obtained, whereas under kinetic control (TFA, room temperature) the trans-derivative 8 was the major product. In contrast, cyclization of amido acetal 12 with TsOH gave the cis-derivative 7 as preponderant component. 相似文献
84.
Cannabis is still the most widely used illicit drug around the world. While its use has always been prevalent among adolescents, recent evidence suggests that its consumption is also increasing among other population groups, such as pregnant women and aged people. Given the known impact of cannabis on brain development and behavior, it is important to dissect the possible long-term impact of its use across different age groups, especially on measures of cognitive performance. Animal models of cannabinoid exposure have represented a fundamental tool to characterize the long-lasting consequences of cannabinoids on cognitive performance and helped to identify possible factors that could modulate cannabinoids effects in the long term, such as the age of exposure and doses administered. This scoping review was systematically conducted using PubMed and includes papers published from 2015 to December 2021 that examined the effects of cannabinoids, either natural or synthetic, on cognitive performance in animal models where exposure occurred in the prenatal period, during adolescence, or in older animals. Overall, available data clearly point to a crucial role of age in determining the long-term effect of cannabinoid on cognition, highlighting possible detrimental consequences during brain development (prenatal and adolescent exposure) and beneficial outcomes in old age. In contrast, despite the recent advances in the field, it appears difficult to clearly establish a possible role of dosage in the effects of cannabinoids on cognition, especially when the adolescent period is taken into account. 相似文献
85.
86.
87.
88.
N-[1-(Phenylsulfonyl)alkyl]oxazolidin-2-ones are successfully prepared by condensation of the corresponding optically active oxazolidin-2-ones with aldehydes and benzenesulfinic acid. At low temperature, in the presence of titanium tetrachloride, these sulfones are converted into N-acyliminium ions, which react with allyltrimethylsilane with a variable degree of stereoselectivity. The best results are obtained with (R)-5,5-dimethyl-4-phenyloxazolidin-2-one as a chiral auxiliary. Cleavage of the oxazolidin-2-one ring with lithium/ammonia affords the corresponding homoallylamines, which reveal an absolute configuration opposite that expected on the basis of the usual steric effects. A complexation of the Lewis acid with the N-acyliminium ion may be responsible of this rather unusual stereochemical outcome. 相似文献
89.
The Cu(+) and Cu(2+) preferred binding sites on alpha-alanine and their affinity values for this amino acid were determined at the density functional level using three different hybrid exchange correlation potentials and the 6-311++G** basis set. The results demonstrated that the two ions both give stable complexes with alpha-alanine but the stability order of the metalated species and the coordination sites are different depending on the nature of the cation. In particular, the Cu(+)-alpha-alanine ground-state structure is characterized by an eta(2)-N,O coordination with the nitrogen and oxygen atoms belonging to the amino and carbonyl groups, respectively. In contrast, the most stable complex of the Cu(2+)-alpha-alanine system has an eta(2)-O,O coordination with the cation bonded to the -CO(2) (-) moiety of the zwitterionic form of the amino acid. Comparison with the Cu(+) and Cu(2+) affinity values for glycine, computed at the same levels of theory, demonstrated that the relative values do not change significantly as different hybrid functionals are used, although the absolute affinities are strongly influenced by the choice of the hybrid potential. 相似文献
90.
The excited state of terpyridine derivatives of phenylene-vinylene fragments chelating Zn(II) show a strong solvatochromism (up to 56 nm) upon preferential solvation by polar solvents of an intraligand charge transfer state. 相似文献