全文获取类型
收费全文 | 254篇 |
免费 | 17篇 |
国内免费 | 1篇 |
专业分类
化学 | 216篇 |
力学 | 3篇 |
数学 | 15篇 |
物理学 | 38篇 |
出版年
2023年 | 12篇 |
2022年 | 11篇 |
2021年 | 9篇 |
2020年 | 11篇 |
2019年 | 8篇 |
2018年 | 8篇 |
2017年 | 2篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 11篇 |
2013年 | 11篇 |
2012年 | 10篇 |
2011年 | 24篇 |
2010年 | 11篇 |
2009年 | 12篇 |
2008年 | 14篇 |
2007年 | 9篇 |
2006年 | 8篇 |
2005年 | 13篇 |
2004年 | 8篇 |
2003年 | 2篇 |
2002年 | 7篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1998年 | 5篇 |
1997年 | 1篇 |
1996年 | 5篇 |
1994年 | 1篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1963年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有272条查询结果,搜索用时 0 毫秒
111.
Paul Eckhardt Quintin Elliot Prof. Dr. Igor V. Alabugin Prof. Dr. Till Opatz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(60):e202201637
Traditionally, cross-dehydrogenative coupling (CDC) leads to C−N bond formation under basic and oxidative conditions and is proposed to proceed via a two-electron bond formation mediated by carbenium ions. However, the formation of such high-energy intermediates is only possible in the presence of strong oxidants, which may lead to undesired side reactions and poor functional group tolerance. In this work we explore if oxidation under basic conditions allows the formation of three-electron bonds (resulting in “upconverted” highly-reducing radical-anions). The benefit of this “upconversion” process is in the ability to use milder oxidants (e. g., O2) and to avoid high-energy intermediates. Comparison of the two- and three-electron pathways using quantum mechanical calculations reveals that not only does the absence of a strong oxidant shut down two-electron pathways in favor of a three-electron path but, paradoxically, weaker oxidants react faster with the upconverted reductants by avoiding the inverted Marcus region for electron transfer. 相似文献
112.
113.
Aurelie V.B. Djoumessi Louis P. Sandjo Johannes C. Liermann Dieter Schollmeyer Victor Kuete Vincent Rincheval Abegaz M. Berhanu Samuel O. Yeboah Pascal Wafo Bonaventure T. Ngadjui Till Opatz 《Tetrahedron》2012,68(24):4621-4627
Three new cyclopropanic oleanane triterpenoids and ten known compounds were obtained from Donella ubanguiensis using chromatographic methods. The structures were established on the basis of mass spectrometric and NMR data and by comparison with values reported in the literature. The structures of the new compounds were confirmed by X-ray crystallography. A part of the isolated compounds was evaluated for cytotoxic and antimicrobial activities. 相似文献
114.
Enzymatic signal amplification by the deposition of insoluble product on the electrode surface enhances impedimetric DNA detection sensitivity. This work demonstrates a method which gives the required detection sensitivity at significantly reduced enzyme reaction times, and demonstrates the capability for DNA SNP discrimination of biologically relevant sequences. This opens up the prospect of more rapid and relevant multiparameter impedimetric bioassays. 相似文献
115.
Till Massing 《Computational Statistics》2018,33(4):1649-1685
Lévy processes have become very popular in many applications in finance, physics and beyond. The Student–Lévy process is one interesting special case where increments are heavy-tailed and, for 1-increments, Student t distributed. Although theoretically available, there is a lack of path simulation techniques in the literature due to its complicated form. In this paper we address this issue using series representations with the inverse Lévy measure method and the rejection method and prove upper bounds for the mean squared approximation error. In the numerical section we discuss a numerical inversion scheme to find the inverse Lévy measure efficiently. We extend the existing numerical inverse Lévy measure method to incorporate explosive Lévy tail measures. Monte Carlo studies verify the error bounds and the effectiveness of the simulation routine. As a side result we obtain series representations of the so called inverse gamma subordinator which are used to generate paths in this model. 相似文献
116.
Luis I. Domenianni Markus Bauer Till Schmidt-Räntsch Jörg Lindner Sven Schneider Peter Vöhringer 《Angewandte Chemie (International ed. in English)》2023,62(42):e202309618
Transition-metal nitrides/nitrenes are highly promising reagents for catalytic nitrogen-atom-transfer reactivity. They are typically prepared in situ upon optically induced N2 elimination from azido precursors. A full exploitation of their catalytic potential, however, requires in-depth knowledge of the primary photo-induced processes and the structural/electronic factors mediating the N2 loss with birth of the terminal metal-nitrogen core. Using femtosecond infrared spectroscopy, we elucidate here the primary molecular-level mechanisms responsible for the formation of a unique platinum(II) nitrene with a triplet ground state from a closed-shell platinum(II) azide precursor. The spectroscopic data in combination with quantum-chemical calculations provide compelling evidence that product formation requires the initial occupation of a singlet excited state with an anionic azide diradical ligand that is bound to a low-spin d8-configured PtII ion. Subsequent intersystem crossing generates the Pt-bound triplet azide diradical, which smoothly evolves into the triplet nitrene via N2 loss in a near barrierless adiabatic dissociation. Our data highlight the importance of the productive, N2-releasing state possessing azide ππ* character as a design principle for accessing efficient N-atom-transfer catalysts. 相似文献
117.
Till MS Essigke T Becker T Ullmann GM 《The journal of physical chemistry. B》2008,112(42):13401-13410
The large interest in long-range proton transfer in biomolecules is triggered by its importance for many biochemical processes such as biological energy transduction and drug detoxification. Since long-range proton transfer occurs on a microsecond time scale, simulating this process on a molecular level is still a challenging task and not possible with standard simulation methods. In general, the dynamics of a reactive system can be described by a master equation. A natural way to describe long-range charge transfer in biomolecules is to decompose the process into elementary steps which are transitions between microstates. Each microstate has a defined protonation pattern. Although such a master equation can in principle be solved analytically, it is often too demanding to solve this equation because of the large number of microstates. In this paper, we describe a new method which solves the master equation by a sequential dynamical Monte Carlo algorithm. Starting from one microstate, the evolution of the system is simulated as a stochastic process. The energetic parameters required for these simulations are determined by continuum electrostatic calculations. We apply this method to simulate the proton transfer through gramicidin A, a transmembrane proton channel, in dependence on the applied membrane potential and the pH value of the solution. As elementary steps in our reaction, we consider proton uptake and release, proton transfer along a hydrogen bond, and rotations of water molecules that constitute a proton wire through the channel. A simulation of 8 mus length took about 5 min on an Intel Pentium 4 CPU with 3.2 GHz. We obtained good agreement with experimental data for the proton flux through gramicidin A over a wide range of pH values and membrane potentials. We find that proton desolvation as well as water rotations are equally important for the proton transfer through gramicidin A at physiological membrane potentials. Our method allows to simulate long-range charge transfer in biological systems at time scales, which are not accessible by other methods. 相似文献
118.
A simple, reliable, and reproducible procedure for the multi‐gram synthesis of highly pure bis(indenyl)dimethyltitanium is presented. The procedure relies on a one‐pot conversion of inexpensive indene, methyllithium, and titanium tetrachloride to [Ind2TiMe2] and a convenient and quick aqueous workup protocol. Overall, quantities of several grams of [Ind2TiMe2] can be synthesized within a few hours. The procedure can also be used for the synthesis of [Cp2TiMe2] from cyclopentadiene, methyllithium, and titanium tetrachloride. 相似文献
119.
We report on experimental results which we conducted on manufactured microretarder arrays. The array consists of miniaturized retarder elements with different orientations of their fast axes. Diffractive phase retardation elements are chosen as microretarder elements since nanostructuring techniques such as electron beam lithography and successive reactive ion etching allow in principle an effortless way to arrange the microretarders as desired by the application. In this paper, we discuss the fabrication and the experimental results of manufactured retarder arrays. Furthermore, their use for potential applications in the fields of polarimetry is discussed. 相似文献
120.
The Stevens rearrangement of a nitrile-stabilized ammonium ylide is the key step of a very short and practical synthesis of the phenanthroindolizine alkaloid (±)-tylophorine. The method requires only five linear steps and is devoid of any protecting group manipulations. 相似文献