Novel and Efficient Synthesis of DHPMs Catalyzed by di‐DACH‐Pyridylamide Ligands

Di‐DACH‐pyridylamide ligands, symmetrical bridged bis‐Schiff base, and spiro pyrrolizines as catalysts in the synthesis of dihydropyrimidinethiones (DHPMs) using the Biginelli reaction is first reported. This new protocol has the advantages of environmental friendliness, short reaction time, excellent yields, and simple post‐treatment procedure. A series of DHPMs were obtained in high yields (up to 98%) in only 6 h. Moreover, based on the optimized condition, a novel Biginelli‐like reaction was first developed.     

Normalized LMS digital filter for chromatic dispersion equalization in 112-Gbit/s PDM-QPSK coherent optical transmission system

High bit rates optical communication systems pose the challenge of their tolerance to linear and non-linear fiber impairments. Coherent optical receivers using digital signal processing techniques can mitigate the fiber impairments in the optical transmission system, including the chromatic dispersion equalization with digital filters. In this paper, an adaptive finite impulse response filter employing normalized least mean square algorithm is developed for compensating the chromatic dispersion in a 112-Gbit/s polarization division multiplexed quadrature phase shift keying coherent communication system, which is established in the VPI simulation platform. The principle of the adaptive normalized least mean square algorithm for signal equalization is analyzed theoretically, and at the meanwhile, the taps number and the tap weights in the adaptive finite impulse response filter for compensating a certain fiber chromatic dispersion are also investigated by numerical simulation. The chromatic dispersion compensation performance of the adaptive filter is analyzed by evaluating the behavior of the bit-error-rate versus the optical signal-to-noise ratio, and the compensation results are also compared with other present digital filters.     

Methane dehydroaromatization with periodic CH4-H2 switch:A promising process for aromatics and hydrogen

Long-term stability test of Mo/HZSM-5-N catalysts(HZSM-5-N stands for nano-sized HZSM-5) in methane dehydroaromatization(MDA)reaction has been performed with periodic CH4-H2 switch at 1033-1073 K for more than 1000 h.During this test,methane conversion ranges from 13% to 16%,and mean yield to aromatics(i.e.benzene and naphthalene) exceeds 10%.N2-physisorption,XRD,NMR and TPO measurements were performed for the used Mo/HZSM-5 catalysts and coke deposition,and the results revealed that the periodic hydrogenation can effectively suppress coke deposition by removing the inert aromatic-type coke,thus ensuring Mo/HZSM-5 partly maintained its activity even in the presence of large amount of coke deposition.The effect of zeolite particle size on the catalytic activity was also explored,and the results showed that the nano-sized zeolite with low diffusion resistance performed better.It is recognized that the size effect was enhanced by reaction time,and it became more remarkable in a long-term MDA reaction even at a low space velocity.     

α-Mangostin exhibits antidepressant-like effects mediated by the modification of GABAergic,serotonergic and dopaminergic systems

Abstract

The present study explored the antidepressant-like activity of α-mangostin (α-MG) and the possible mechanism in this process in the tail suspension test (TST) in mice. The results revealed that α-MG (5?mg/kg, i.p.) exhibited markedly antidepressant-like activity, which could be reversed by pretreatment with haloperidol (a non-selective D₂ receptor antagonist), bicuculline (a competitive GABA antagonist), p-chlorophenylalanine (an inhibitor of 5-HT synthesis). Meanwhile, α-MG also effectively increased the brain DA, 5-HT and GABA levels in mice exposed to TST, indicating that the antidepressant-like effect of α-MG might be mediated by the GABAergic, serotonergic and dopaminergic systems.

     

谈谈悬念在化学教学中的应用

教学悬念,指的是教师将教材内容引发出一种魅力,使学生产生关切的心情。有的老师认为悬念是一种文学技巧,与化学教学关系不大。其实不然。悬念的应用是一种教学艺术,能有效地开发学生的智力。     

The sandwich-type electrochemiluminescence immunosensor for α-fetoprotein based on enrichment by Fe3O4-Au magnetic nano probes and signal amplification by CdS-Au composite nanoparticles labeled anti-AFP

A novel and sensitive sandwich-type electrochemiluminescence (ECL) immunosensor was fabricated on a glassy carbon electrode (GCE) for ultra trace levels of α-fetoprotein (AFP) based on sandwich immunoreaction strategy by enrichment using magnetic capture probes and quantum dots coated with Au shell (CdS-Au) as the signal tag. The capture probe was prepared by immobilizing the primary antibody of AFP (Ab1) on the core/shell Fe₃O₄-Au nanoparticles, which was first employed to capture AFP antigens to form Fe₃O₄-Au/Ab1/AFP complex from the serum after incubation. The product can be separated from the background solution through the magnetic separation. Then the CdS-Au labeled secondary antibody (Ab2) as signal tag (CdS-Au/Ab2) was conjugated successfully with Fe₃O₄-Au/Ab1/AFP complex to form a sandwich-type immunocomplex (Fe₃O₄-Au/Ab1/AFP/Ab2/CdS-Au), which can be further separated by an external magnetic field and produce ECL signals at a fixed voltage. The signal was proportional to a certain concentration range of AFP for quantification. Thus, an easy-to-use immunosensor with magnetic probes and a quantum dots signal tag was obtained. The immunosensor performed at a level of high sensitivity and a broad concentration range for AFP between 0.0005 and 5.0 ng mL⁻¹ with a detection limit of 0.2 pg mL⁻¹. The use of magnetic probes was combined with pre-concentration and separation for trace levels of tumor markers in the serum. Due to the amplification of the signal tag, the immunosensor is highly sensitive, which can offer great promise for rapid, simple, selective and cost-effective detection of effective biomonitoring for clinical application.     

用于MM3装置实验的微型计算机数据采集和处理系统

本文介绍了APPLE-Ⅱ微型计算机构成的数据采集和处理系统,及其在MM3稳态磁镜实验装置上进行的数据采集、数据处理,由此而获得的等离子体有关温度、密度和电位等参数。     

EXACT SOLITRAY WAVE SOLUTIONS AND SINGULAR SOLUTIONS TO THE TWO-DIMENSIONAL NONLINEAR DISSIPATIVE-DISPERSIVE SYSTEM

IIntroductlonIntegrMle systems;both classical ajnd quantum me山anies,are aMclnatingsubject·Decades ofresearch In this areahave led to mathematical developme血s that are quite beau－tiful．However,not ail systems posed in physics are Integrable,M Instajnce,the Korteweg－deVies－Burgers(KdV－Burgers),Kur。ot。SI、hinsky(KS)and ifth－order dispersi、Kortevegde Vries(ifth－order KdV)eqUatio。 Therefore the direct methods to sol。nonlinear systemsppear to be more important．In this paper…     

基于四阶累计量的固定噪音参量估计

根据高斯噪音高于二阶的累积量为零的特性,提出基于四阶累计量的红外焦平面固定噪音乘性参量估计算法,完成从图象场景中自适应估计阵列单元的增益.利用泰勒级数展开给出乘性参量估计均值和方差的统计特性,证明算法给出乘性增益的估计为渐进无偏估计.提出的算法用蒙特卡罗仿真给予验证,证明了算法的有效性.并将提出的算法应用于实际图象的处理,有效降低了固定图案噪音,达到了较高的非均匀校正水平.