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51.
Sandrine Henry De Hassonville Bruno Perly Géraldine Piel Thierry Van Hees Valéry Barillaro Pascal Bertholet Luc Delattre Brigitte Evrard 《Journal of inclusion phenomena and macrocyclic chemistry》2002,44(1-4):289-292
Cyproterone acetate (CPA) is a steroidal antiandrogen with a progestogenic activity. Given that this molecule has a very poor water solubility (2.1 g/mL), different cyclodextrins (CDs) were tested to form inclusion complexes and to increase solubility. Two different techniques were compared to study the affinity between CPA and CDs: phase-solubility studies and NMR spectroscopy. The stoichiometry and the stability constant could be determined for most complexes with the aid of phase-solubility studies. The greatest increase in solubility was achieved with the methylated -CDs, but hydroxypropylated - and -CDs also gave enhanced solubilities. 1H-NMR studies showed a solubility increase similar to that found with phase-solubility studies. The proof of inclusion in the2,6-dimethyl--CD (DIMEB) was shown by 1H-NMR and t-ROESY spectra. 相似文献
52.
Phosphate selective electrodes have been produced based upon rubbery membranes containing heterocylic macrocycles as sensors covalently bound to a cross-linked polystyrene-block–polybutadiene-block–polystyrene (SBS) polymer. The membranes were robust and the best HPO42−-selective membrane fabricated was composed of 7.1% (m/m) dicumyl peroxide, 28.3% (m/m) 2-nitrophenyloctylether, 9.8% (m/m) 3-(10-undecenyl)-1,5,8-triazacyclodecane-2,4-dione, 31.0% (m/m) SBS and 23.8% (m/m) PoleStar™ 200R (clay-based filler). The characteristics of this electrode were a linear Nernstian range of 3.9×10−3 to 1×10−6 mol dm−3 HPO42− with a limit of detection of 1.0×10−6 mol dm−3 HPO42−, a slope of −29.7±0.9 mV per activity decade and a pH range from 6 to 8. Selectivity coefficients for phosphate against various interfering anions (chloride, sulfate and nitrate) were determined. Response times were 2 min or under, stability of response and electrode lifetime in continuous use were also very satisfactory. The response behavior of HPO42−-ISEs based upon mobile and bound ionophores was comparable and suggests that mobility of the ionophore is not necessary to obtain a working ISE and that covalent binding of ionophores can be used to produce ISEs of increased stability and robustness. 相似文献
53.
Matthew Myers Eric F. Connor Thierry Glauser Andreas Mck Gregory Nyce James L. Hedrick 《Journal of polymer science. Part A, Polymer chemistry》2002,40(7):844-851
A new metal‐free synthetic approach to the controlled ring‐opening polymerization (ROP) of lactide with nucleophilic phosphines as transesterification catalysts is described. P(Bu)3, PhPMe2, Ph2PMe, PPh3, and related phosphines are commercially available, inexpensive catalysts that generate narrowly dispersed polylactides with predictable molecular weights. These organic catalysts must be used in combination with an initiator, such as an alcohol, to generate an alcoholate ester α‐end group upon ROP. A likely polymerization pathway is through a monomer‐activated mechanism, with minimal active species, facilitating narrow molecular weight distributions. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 844–851, 2002; DOI 10.1002/pola.10168 相似文献
54.
Bismuth triflate catalyzes the allylation of a variety of in situ generated protected aldimines using aldehydes, primary carbamates, and allyltrimethylsilane in a three-component reaction. The reaction proceeds rapidly and affords the corresponding protected homoallylic amine in good yield (up to 86%). Scope and limitations of the aldehyde and carbamate components are reported. 相似文献
55.
Investigation of the Interactions of β‐Peptides with DNA Duplexes by Circular Dichroism Spectroscopy
Kenji Namoto James Gardiner Thierry Kimmerlin Dieter Seebach 《Helvetica chimica acta》2006,89(12):3087-3103
The interaction of β‐peptides with the DNA duplexes of dA20dT20 and a GCN4‐binding CRE sequence was examined. To gauge the factors that govern these interactions, two β‐pentadecapeptides, 1 and 2 , a β‐dodecapeptide, 3 , three β‐decapeptides, 4 – 6 , three β‐heptapeptides, 7 – 9 , and β‐octaarginine 10 were designed and synthesized. The β‐peptides were conceived to adopt a β‐peptide 314 helix, in which the side chains at position i and i + 3 are aligned vertically along one side of the helix. The side chains of Lys, Asn, and Arg were positioned such that potential H‐bonding sites were created for a helical conformation to interact with the base pairs of DNA. CD Analysis showed that β‐peptides 1, 2 , and 10 interacted with dA20dT20. In addition, β‐peptides 1 and 2 showed significant interaction with a DNA‐duplex 20mer containing the ATF/CREB recognition sequence for the regulatory protein GCN4. It is impossible, at this stage of the investigation, to make a safe proposal about the actual nature of the interaction of the structures(s) of the complexes, the formation of which is suggested by the CD spectra reported herein. 相似文献
56.
Thierry Boulanger Christine Evrard Daniel P. Vercauteren Guy Evrard François Durant 《Journal of chemical crystallography》1991,21(3):287-295
The crystal structures ofp-methoxyphenyl-3-triazolo [4,3-a] isoquinoline (SR95926),p-methoxyphenyl-3-triazolophtalazine (CMW1842), andp-methoxyphenyl-3-N-dimethoxyethylamino-6-triazolophtalazine (L16317) have been solved by direct methods from single-crystal X-ray diffraction data, and refined by full-matrix least squares. SR95926: monoclinic,P21/n,a=20.950(3),b=6.769(1),c=9.465(2) Å,=100.90(1)°. CMW1842: triclinic,P¯1,a=8.784(1),b=9.160(4),c=8.555(1) Å,=99.10(2),=93.90(1), =106.77(1)°. L16317: monoclinic,P21/n,a=20.124(3),b=9.586(1),c=10.788(1) Å,=91.91(1)°. FinalR factors are 0.034, 0.037, and 0.053, respectively. Experimental geometries were used to perform STO-3Gab initio molecular-orbital calculations. A relationship between the electronic pattern within the molecules and the affinity of the benzodiazepine receptor sites is pointed out. 相似文献
57.
Thierry Coquand 《BIT Numerical Mathematics》1992,32(1):10-14
We show how to represent a paradox similar to Russell's paradox in Type Theory withW-types and a type of all types, and how to use this in order to represent a fixed-point operator in such a theory. It is still open whether such a construction is possible without theW-type.This research was partly supported by ESPIRIT Basic Research Action Logical Frameworks. 相似文献
58.
Thierry Coulhon 《Potential Analysis》1992,1(4):343-353
One shows the equivalence between an abstract form of a Gagliardo-Nirenberg inequality and an estimate of the decay of the L
1–L
norm of a semigroup of operators. This equivalence, contrary to the one with the classical Sobolev inequalities, allows the treatment of situations where the decay is exponential. Related results and applications are given.
Cet article a pu être terminé pendant un séjour de l'auteur à l'université d'Edimbourg. 相似文献
59.
We consider global solutions of the nonlinear Schrödinger equation
相似文献
60.
Tae-Kyu Ha Urs P. Wild Ren O. Kühne Charles Loesch Thierry Schaffhauser Johanna Stachel Alexander Wokaun 《Helvetica chimica acta》1978,61(3):1193-1199
Ab initio SCF and CI calculations on the cationic and neutral complexes of formaldehyde and lithium are reported. For the cationic complex CH2O/Li+, the stabilization energy of 41.7 kcal/mol obtained from the SCF calculation increases to 51.6 kcal/mol if a configuration interaction is introduced. For the neutral complex CH2O?/Li+, the C2v-conformer of the 2A1-state with the equilibrium bond distances of d(C? O) = 1.23 Å and d (O? Li) = 1.90 Å is calculated to be more stable than the 2B1-state with d (C? O) = 1.34 Å, and d (O? Li) = 1.65 Å. Charge transfer and polarization effects upon complex formation are discussed. 相似文献
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