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71.
Kevin Grollier Arnaud De Zordo-Banliat Flavien Bourdreux Dr. Bruce Pegot Dr. Guillaume Dagousset Dr. Emmanuel Magnier Dr. Thierry Billard 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(19):6028-6033
The synthesis of molecules bearing (trifluoromethylselenyl)methylchalcogenyl groups is described via an efficient two-step strategy based on a metal-free photoredox catalyzed decarboxylative trifluoromethylselenolation with good yields up to 88 %, which raised to 98 % in flow chemistry conditions. The flow methods allowed also to scale up the reaction. The mechanism of this key reaction was studied. The physicochemical characterization of these emerging groups was performed by determining their Hansch–Leo lipophilicity parameters with high values up to 2.24. This reaction was also extended to perfluoroalkylselenolation with yields up to 95 %. Finally, this method was successfully applied to the functionalization of relevant bioactive molecules such as tocopherol or estrone derivatives. 相似文献
72.
Tistaert C Thierry L Szandrach A Dejaegher B Fan G Frédérich M Vander Heyden Y 《Analytica chimica acta》2011,705(1-2):111-122
Extracts of Citri reticulatae pericarpium (PCR) are commonly used in the Traditional Chinese Medicine. The quality control of PCR is currently performed by single marker analysis, which can hardly describe the complexity of such natural samples. In this study, a fingerprint methodology for PCR based on high-performance liquid chromatography (HPLC) was developed and validated. A total of 69 fingerprints of authenticated PCR samples, commercial PCR samples, mixed peel samples, and other Citrus peels were recorded. Exploratory data analysis allowed optimizing the extraction procedure and detecting mixed peel samples. Once the optimizations were performed and the method validated, discrimination between the authentic PCR samples and all other samples was performed by p-Discriminant Partial Least Squares. The established model was able to differentiate between classes with a high reliability for each sample. Furthermore, evaluation of the score and loading plots of the model indicated nobiletin, tangeretin, naringin and hesperidin as important markers for the quality control of PCR. 相似文献
73.
Ahmad S Jousseaume B Servant L Toupance T Zakri C 《Chemical communications (Cambridge, England)》2011,47(17):5001-5003
Unprecedented stable hybrid materials with cyclopentadienyl-titanium bonds have been obtained from the hydrolysis of suitable precursors. Their inorganic network is not fully condensed and they show variable short-range self-organizations, the type of which depends on the shape of the ligands. 相似文献
74.
Teixeira C Gomes JR Couesnon T Gomes P 《Journal of computer-aided molecular design》2011,25(8):763-775
Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) based on three-dimensional
quantitative structure–activity relationship (3D-QSAR) studies were conducted on a series (39 molecules) of peptidyl vinyl
sulfone derivatives as potential Plasmodium Falciparum cysteine proteases inhibitors. Two different methods of alignment were employed: (i) a receptor-docked alignment derived
from the structure-based docking algorithm GOLD and (ii) a ligand-based alignment using the structure of one of the ligands
derived from a crystal structure from the PDB databank. The best predictions were obtained for the receptor-docked alignment
with a CoMFA standard model (q
2 = 0.696 and r
2 = 0.980) and with CoMSIA combined electrostatic, and hydrophobic fields (q
2 = 0.711 and r
2 = 0.992). Both models were validated by a test set of nine compounds and gave satisfactory predictive r
2
pred values of 0.76 and 0.74, respectively. CoMFA and CoMSIA contour maps were used to identify critical regions where any change
in the steric, electrostatic, and hydrophobic fields may affect the inhibitory activity, and to highlight the key structural
features required for biological activity. Moreover, the results obtained from 3D-QSAR analyses were superimposed on the Plasmodium Falciparum cysteine proteases active site and the main interactions were studied. The present work provides extremely useful guidelines
for future structural modifications of this class of compounds towards the development of superior antimalarials. 相似文献
75.
β-(Trifluoromethyl) enones, easily obtained in few steps from commercially available methyl hemiketal of trifluoroacetaldehyde, react with electron-rich O- and N-containing heterocycles (furans and benzofurans, pyrroles and indoles, hydroxycoumarins), through a 1,4 addition, to give heterocycles bearing a functionalized side-chain. β-(chlorodifluoromethyl)enones and β-(pentafluoroethyl)enones behave in the same way. 相似文献
76.
André Deratani Thierry Maraldo Estelle Renard 《Journal of inclusion phenomena and macrocyclic chemistry》1995,23(2):137-146
Reduction of-cyclodextrin (-CD) aromatic ketone (acetophenone and acetonaphthones) inclusion compounds were carried out in the presence of a large number of chemically inert species as potential co-guests. In several cases, it was observed that stoichiometric molar ratios of these compounds to ketone significantly modify the chiral induction yielding the inverted alcohol enantiomer and increasing the face selectivity. The results were found to depend strongly on the respective structure and shape of both the ketone and the additive, and on the molar ratio of-CD:ketone:third compound. These observations suggest the formation of a three-component inclusion complex in which the geometry of binding of the substrate and its mobility are changed with respect to the binary system. 相似文献
77.
Volkringer C Henry N Grandjean S Loiseau T 《Journal of the American Chemical Society》2012,134(2):1275-1283
A series of uranyl and lanthanide (trivalent Ce, Nd) mellitates (mel) has been hydrothermally synthesized in aqueous solvent. Mixtures of these 4f and 5f elements also revealed the formation of a rare case of lanthanide-uranyl coordination polymers. Their structures, determined by XRD single-crystal analysis, exhibit three distinct architectures. The pure lanthanide mellitate Ln(2)(H(2)O)(6)(mel) possesses a 3D framework built up from the connection of isolated LnO(6)(H(2)O)(3) polyhedra (tricapped trigonal prism) through the mellitate ligand. The structure of the uranyl mellitate (UO(2))(3)(H(2)O)(6)(mel)·11.5H(2)O is lamellar and consists of 8-fold coordinated uranium atoms linked to each other through the organic ligand giving rise to the formation of a 2D 3(6) net. The third structural type, (UO(2))(2)Ln(OH)(H(2)O)(3)(mel)·2.5H(2)O, involves direct oxygen bondings between the lanthanide and uranyl centers, with the isolation of a heterometallic dinuclear motif. The 9-fold coordinated Ln cation, LnO(5)(OH)(H(2)O)(3), is linked to the 7-fold coordinated uranyl (UO(2))O(4)(OH) (pentagonal bipyramid) via one μ(2)-hydroxo group and one μ(2)-oxo group. The latter is shared between the uranyl bonding (U═O = 1.777(4)/1.779(6) ?) and a long Ln-O bonding (Ce-O = 2.822(4) ?; Nd-O = 2.792(6) ?). This unusual linkage is a unique illustration of the so-called cation-cation interaction associating 4f and 5f metals. The dinuclear motif is then further connected through the mellitate ligand, and this generates organic-inorganic layers that are linked to each other via discrete uranyl (UO(2))O(4) units (square bipyramid), which ensure the three-dimensional cohesion of the structure. The mixed U-Ln carboxylate is thermally decomposed from 260 to 280 °C and then transformed into the basic uranium oxide (U(3)O(8)) together with U-Ln oxide with the fluorite structural type ("(Ln,U)O(2)"). At 1400 °C, only fluorite type "(Ln,U)O(2)" is formed with the measured stoichiometry of U(0.63)Ce(0.37)O(2) and U(0.60)Nd(0.40)O(2-δ). 相似文献
78.
Leufroy A Noël L Beauchemin D Guérin T 《Analytical and bioanalytical chemistry》2012,402(9):2849-2859
A continuous leaching method coupled online with inductively coupled plasma mass spectrometry (ICP-MS) detection was used
to assess the maximum bioaccessibility of arsenic (As) in seafood samples. The method simulates continuous-flow digestion
by successively pumping artificial saliva, gastric and intestinal juices through a mini-column of powdered sample directly
connected to the nebuliser of an ICP-MS instrument. The method allows the real-time measurement of As being released by a
given reagent. Because the analyte is continuously removed from the system, in contrast to batch methods, the dissolution
equilibrium is driven to the right, hence quickly providing information about the worst-case scenario. Following consecutive
leaching by the digestive reagents, the leachates were subject to speciation analysis by ion-exchange chromatography with
ICP-MS detection to determine the arsenic species released. Finally, the remaining residue from the mini-column was fully
digested to verify mass balance. The method was used to determine the bioaccessibility of total As and As species in four
certified reference materials and in several real seafood samples. The mass balance was verified in each case. Generally speaking,
the non-toxic form was easily released whereas the inorganic forms were poorly bioaccessible. 相似文献
79.
Guiguemde WA Shelat AA Garcia-Bustos JF Diagana TT Gamo FJ Guy RK 《Chemistry & biology》2012,19(1):116-129
Malaria, a devastating infectious disease caused by Plasmodium spp., leads to roughly 655,000 deaths per year, mostly of African children. To compound the problem, drug resistance has emerged to all classical antimalarials and may be emerging for artemisinin-based combination therapies. To address the need for new antimalarials with novel mechanisms, several groups carried out phenotypic screening campaigns to identify compounds inhibiting growth of the blood stages of Plasmodium falciparum. In this review, we describe the characterization of these compounds, explore currently ongoing strategies to develop lead molecules, and endorse the concept of a "malaria box" of publicly accessible active compounds. 相似文献
80.