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61.
Du Q Jerz G Ha Y Li L Xu Y Zhang Q Zheng Q Winterhalter P Ito Y 《Journal of chromatography. A》2005,1074(1-2):43-46
Salicin in the bark extract of Salix alba and amygdalin in the fruit extract of Semen armeniacae were each separated by slow rotary counter-current chromatography (SRCCC). The apparatus was equipped with a 40-L column made of 17 mm i.d. convoluted Teflon tubing. A 500g amount of crude extract containing salicin at 13.5% was separated yielding 63.5 g of salicin at 95.3% purity in 20h using methyl tert-butyl ether-l-butanol (1:3) saturated by methanol-water (1:5) as a stationary phase and methanol-water (1:5) saturated by methyl tert-butyl ether-1-butanol (1:3) as a mobile phase. A 400g amount of crude extract containing amygdalin at 55.3% was isolated to yield 221.2g of amygdalin at 94.1% purity in 19h using ethyl acetate-1-butanol (1:2) saturated by water as a stationary phase and water saturated by ethyl acetate-1-butanol (1:2) as a mobile phase. The flow rate of the mobile phase was 50 ml/min. The results show that industrial SRCCC separation of salicin and amygdalin is feasible using a larger column at a higher flow rate of the mobile phase. 相似文献
62.
C. Decker H. Le Xuan T. Nguyen Thi Viet 《Journal of polymer science. Part A, Polymer chemistry》1995,33(16):2759-2772
Low molecular weight epoxidized natural rubber has been crosslinked within seconds by UV irradiation in the presence of a triarylsulfonium salt. The photoinitiated cationic ring-opening polymerization was studied quantitatively by infrared spectroscopy and shown to proceed with surprisingly long kinetic chains in such solid medium. The high conversion (60%) needed for complete insolubilization, together with the presence of tetrahydrofuran structures, argue in favor of an intramolecular polymerization process involving neighboring epoxy groups. The photoinitiator concentration has a strong influence on the rate and extent of the reaction, as well as on the depth of cure profile. Because of an efficient dark process, close to 100% conversion was reached upon storage of the irradiated elastomer at ambient, with a concomitant increase of the gel fraction and the polymer hardness. The grafting of pendent acrylate groups onto the polymer chain leads to a three-fold decrease of the initial rate of polymerization of the epoxide. The photocuring of natural rubber bearing both epoxy and acrylate groups generates a dual polymer network which combines the properties of the two moieties. © 1995 John Wiley & Sons, Inc. 相似文献
63.
N,N-Diethyldithiocarbamate functionnalized 1,4-polyisoprenes were prepared from 1,4-polyisoprenes (natural or synthetic). The syntheses were performed by nucleophilic addition of N,N-diethyldithiocarbamate salts upon oxirane rings of epoxidized units according to a SN2 mechanism with ring opening. Studies on model molecules of epoxidized 1,4-polyisoprene units (1,2-epoxy-1-methylcyclohexane and 4,5-epoxy-4-methyloctane) were previously achieved to develop the procedure. The best yields were obtained at low temperature in polar medium, and more especially in water with sodium N,N-diethyldithiocarbamate (DEDT-Na) as reagent. A diastereospecific addition was noted when reaction was performed in water with DEDT-Na. Afterwards, the developed procedure was successfully generalized to epoxidized synthetic polyisoprenes and epoxidized natural rubber (in THF, then in latex medium). Excellent results were obtained in latex medium with epoxidized natural rubber (ENR) latices. As with the models, a diastereospecific addition of sodium N,N-diethyldithiocarbamate trihydrate onto epoxidized 1,4-polyisoprene units of ENR was observed at the condition to bring the latex medium to pH 8 before introduction of DEDT-Na. Influence of temperature, drc, and DEDT-Na concentration were successively examined to determine the best conditions of the addition on ENR latices. 相似文献
64.
Self-assembling DNA tiling lattices represent a versatile system for nanoscale construction. Self-assembled DNA arrays provide an excellent template for spatially positioning other molecules with increased relative precision and programmability. Here we report an experiment using a linear array of DNA triple crossover tiles to controllably template the self-assembly of single-layer or double-layer linear arrays of streptavidin molecules and streptavidin-conjugated nanogold particles through biotin-streptavidin interaction. The organization of streptavidin and its conjugated gold nanoparticles into periodic arrays was visualized by atomic force microscopy and scanning electron microscopy. 相似文献
65.
The adsorption of a basic dye (Methylene Blue; MB) and an acidic dye (Acid Orange; AO) has been studied on three activated carbons (ACs; FAS, SKD, and BAU) significantly differing in their porous structures and surface concentrations of ion-exchange groups and on graphitic thermal carbon black (GTCB). The effective specific surface area of FAS, SKD, and BAU determined by dye adsorption is, respectively, 60, 50, and 40% of the BET nitrogen adsorption surface area. The MB uptake on ACs and GTCB increases with rising pH, while the AO uptake decreases. Addition of an electrolyte (0.3 M NaCl) virtually does not effect the adsorption of dyes on ACs and GTCB. It is suggested that hydrophobic interactions, and not ionic ones, are the major contributors to the adsorption of dyes on ACs. 相似文献
66.
Mildred M. Maguire Huang Do Son Kim Nguyen Chau Vo Douglas Smith Grant Koher Gregg Doutt Martyn C.R. Symons 《Journal of organometallic chemistry》1984,269(2):183-189
Exposure of (C5H5)2MO(CH3)2 and (C5H5)2W(CH3)2, prepared from the corresponding dichlorides, to 20Co γ-rays at 77 K gave H2C.CML3 carbene species characterised by their ESR spectra, together with a central feature possibly due to the parent cations. Dilute solutions in CD3OD gave features assigned to the parent anions which were converted on bleaching with visible light into methyl radicals, and H2C.ML3 radicals. From the magnitude of the 1H and 183W hyperfine coupling constants, it is deduced that the SOMO for H2C.WL3 radicals is strongly localised on carbon.Dilute solutions in aqueous sulphuric acid also gave species with A(2H) = 20 G, identified as the carbene derivatives, H2C.Ml3. These were formed on annealing, as signals assigned to HSO4 · radicals were lost. 相似文献
67.
Amber L. H. Gray Aleksandra Antevska Benjamin A. Link Bryan Bogin Susan J. Burke Samuel D. Dupuy J. Jason Collier Zachary A. Levine Michael D. Karlstad Thanh D. Do 《Chemical science》2021,12(16):5853
Despite being relatively benign and not an indicative signature of toxicity, fibril formation and fibrillar structures continue to be key factors in assessing the structure–function relationship in protein aggregation diseases. The inability to capture molecular cross-talk among key players at the tissue level before fibril formation greatly accounts for the missing link toward the development of an efficacious therapeutic intervention for Type II diabetes mellitus (T2DM). We show that human α-calcitonin gene-related peptide (α-CGRP) remodeled amylin fibrillization. Furthermore, while CGRP and/or amylin monomers reduce the secretion of both mouse Ins1 and Ins2 proteins, CGRP oligomers have a reverse effect on Ins1. Genetically reduced Ins2, the orthologous version of human insulin, has been shown to enhance insulin sensitivity and extend the life-span in old female mice. Beyond the mechanistic insights, our data suggest that CGRP regulates insulin secretion and lowers the risk of T2DM. Our result rationalizes how migraine might be protective against T2DM. We envision the new paradigm of CGRP : amylin interactions as a pivotal aspect for T2DM diagnostics and therapeutics. Maintaining a low level of amylin while increasing the level of CGRP could become a viable approach toward T2DM prevention and treatment.CGRP concentration is elevated in migraine conditions. The protective effect of migraine against type 2 diabetes is attributed to the ability of CGRP to remodel human amylin aggregation and to suppress the secretion of mouse insulin 2 (the orthologue of human insulin). 相似文献
68.
Tae-Kyu Ha Urs P. Wild Ren O. Kühne Charles Loesch Thierry Schaffhauser Johanna Stachel Alexander Wokaun 《Helvetica chimica acta》1978,61(3):1193-1199
Ab initio SCF and CI calculations on the cationic and neutral complexes of formaldehyde and lithium are reported. For the cationic complex CH2O/Li+, the stabilization energy of 41.7 kcal/mol obtained from the SCF calculation increases to 51.6 kcal/mol if a configuration interaction is introduced. For the neutral complex CH2O?/Li+, the C2v-conformer of the 2A1-state with the equilibrium bond distances of d(C? O) = 1.23 Å and d (O? Li) = 1.90 Å is calculated to be more stable than the 2B1-state with d (C? O) = 1.34 Å, and d (O? Li) = 1.65 Å. Charge transfer and polarization effects upon complex formation are discussed. 相似文献
69.
[reaction: see text] It has been demonstrated for the first time that conjugated enynes can be employed as a facile substrate in olefin metathesis with the use of a bispyridine-substituted ruthenium benzylidene catalyst. Cross-metathesis of the enynes with alkenes turns out to proceed with preferential formation of (Z)-isomers over (E)-isomers up to >25:1 in moderate to good yields. The intramolecular version of conjugated enynes affords novel butadienyl cycloalkenes, which are a highly useful synthetic building blocks, in acceptable yields. 相似文献
70.
H. -W. Sun W. -J. Kang J. Ha S. -X. Liang S. -G. Shen 《Journal of the Iranian Chemical Society》2004,1(1):40-46
The species of Cr(III) and Cr(VI) in water samples were determined by flow injection on-line preconcentration and separation on two-microcolumn system-derivative flame atomic absorption spectrometry during a collaborative analysis for certification. The Cr(III) and Cr(VI) in water samples were retained on two microcolumns with ion exchange resin and were eluted directly to nebulizer by 15% HNO3 and 8% NH4NO3, respectively. The characteristic concentration (at the sensitivity grade of 2 mV min?1 for 1 min of preconcentration time) for Cr(III) and Cr(VI) were 0.130 and 0.0985 μg l?1, in the order which were 332- and 431-fold better than those of FAAS, and 45- and 47-fold better than those of FI-FAAS, respectively. The relative standard deviations were 3.27% and 3.66% with corresponding detection limits (3σ) of 0.244 and 0.235 μg l?1, respectively. The linear ranges of determinations for Cr(III) and Cr(VI) were 0~100 μgm l?1 with correlation coefficients of 0.9984 to 0.9996. The satisfactory recovery of 94.4%~106% for Cr(III) and Cr(VI) could be obtained from water samples. 相似文献