排序方式: 共有16条查询结果,搜索用时 15 毫秒
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Ghulam Md. Ashraf Debarati DasGupta Mohammad Zubair Alam Saleh S. Baeesa Badrah S. Alghamdi Firoz Anwar Thamer M. A. Alqurashi Sharaf E. Sharaf Waleed Al Abdulmonem Mohammed A. Alyousef Fahad A. Alhumaydhi Anas Shamsi 《Molecules (Basel, Switzerland)》2022,27(14)
Microtubule affinity regulating kinase 4 (MARK4) regulates the mechanism of microtubules by its ability to phosphorylate the microtubule-associated proteins (MAP’s). MARK4 is known for its major role in tau phosphorylation via phosphorylating Ser262 residue in the KXGS motif, which results in the detachment of tau from microtubule. In lieu of this vital role in tau pathology, a hallmark of Alzheimer’s disease (AD), MARK4 is a druggable target to treat AD and other neurodegenerative disorders (NDs). There is growing evidence that NDs and diabetes are connected with many pieces of literature demonstrating a high risk of developing AD in diabetic patients. Metformin (Mtf) has been a drug in use against type 2 diabetes mellitus (T2DM) for a long time; however, recent studies have established its therapeutic effect in neurodegenerative diseases (NDs), namely AD, Parkinson’s disease (PD) and amnestic mild cognitive impairment. In this study, we have explored the MARK4 inhibitory potential of Mtf, employing in silico and in vitro approaches. Molecular docking demonstrated that Mtf binds to MARK4 with a significant affinity of −6.9 kcal/mol forming interactions with binding pocket’s critical residues. Additionally, molecular dynamics (MD) simulation provided an atomistic insight into the binding of Mtf with MARK4. ATPase assay of MARK4 in the presence of Mtf shows that it inhibits MARK4 with an IC50 = 7.05 µM. The results of the fluorescence binding assay demonstrated significant binding of MARK4 with a binding constant of 0.6 × 106 M−1. The present study provides an additional axis towards the utilization of Mtf as MARK4 inhibitor targeting diabetes with NDs. 相似文献
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Al Doury Raaid Rashad Jassem Salem Thamer Khalif Nazzal Ibrahim Thamer Kumar Ravinder Sadeghzadeh Milad 《Journal of Thermal Analysis and Calorimetry》2021,145(3):1151-1161
Journal of Thermal Analysis and Calorimetry - The present article focuses on finding a more accurate method to draw the energy and exergy flows that have drawn previously by many researchers. These... 相似文献
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Abu-Hamdeh Nidal H. Melaibari Ammar A. Alquthami Thamer S. Khoshaim Ahmed Oztop Hakan F. Golmohammadzadeh Ali 《Journal of Thermal Analysis and Calorimetry》2021,144(6):2615-2625
Journal of Thermal Analysis and Calorimetry - In this study, the effectiveness of the heat sink with an insulated wall equipped with nano-PCM and air-cooled one was compared. Heat sink... 相似文献
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Meera Moydeen Abdul Hameed Syed Ali Padusha Mohamed Khan Badr M. Thamer Nirmala Rajkumar Hany El-Hamshary Mohamed El-Newehy 《先进技术聚合物》2023,34(1):6-23
Electrospinning procedures such as blend electrospinning, coaxial electrospinning, and emulsion electrospinning have been used for the fabrication of electrospun nanofibers (ENFs) for biomedical applications. These ENFs are attracted great interest especially in drug delivery applications due to their small size, high surface area-to-volume, and porosity. The aim of this review is to focus on the controlled release mechanism among the different electrospinning methods, and the selectivity of hydrophilic, water-soluble polymers as a carrier for drug. The mechanism for the drug delivery depends mainly on the method of drug loading, polymeric interactions, and the nature of polymer swelling, erosion, or degradation. This review compressed on the literature survey about the fabrication of nanofibers by different electrospinning methods, factors affecting the nanofiber morphologies, selectivity of polymeric blends for successful controlled release behavior, and the mechanism involved in the drug release steps. 相似文献
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Deetlefs M Hussey CL Mohammed TJ Seddon KR van den Berg JA Zora JA 《Dalton transactions (Cambridge, England : 2003)》2006,(19):2334-2341
The electrochemistry of the salts, [emim]2[UBr6] and [emim]2[UO2Br4] ([emim] = 1-ethyl-3-methylimidazolium), has been investigated in both a basic and an acidic bromoaluminate(III) ionic liquid. In the basic ionic liquid, the hexabromo salt undergoes a one-electron reversible reduction process at a stationary glassy carbon disc electrode, while the tetrabromodioxo salt was reduced to a uranium(IV) species by an irreversible two-electron process with the simultaneous transfer of oxide to the ionic liquid. On the other hand, dissolution of either of the salts in an acidic bromoaluminate(III) ionic liquid resulted in the formation of the same electroactive species. The solid state structures of the uranium chloride salts, [emim]2[UCl6] and [emim]2[UO2Cl4], have previously been reported, but have now been re-evaluated using a new statistical model developed in our group, to determine the presence or absence of weak hydrogen bonding interactions in the crystalline state. 相似文献