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排序方式: 共有117条查询结果,搜索用时 656 毫秒
31.
卟啉纳米材料制备及在可视化传感器中的应用 总被引:1,自引:0,他引:1
在水/油体系中,利用表面活性剂辅助自组装制备出5,10,15,20-四苯基卟啉锌(ZnTPP)和5,10,15,20-四苯基卟啉钴(CoTPP)纳米材料,改变陈化时间制备多种形貌卟啉纳米材料,如纳米球、纳米棒和纳米片等。利用紫外-可见光谱和荧光光谱分析两种卟啉纳米材料的光学性质,ZnTPP纳米材料的荧光强度是其单体的4.5倍,具有良好光敏性。基于两种卟啉纳米材料构建可视化阵列芯片对挥发性气体己醛检测,卟啉纳米的响应度是它们单体的2倍。 相似文献
32.
Ramazan Sever Cevdet Tezcan Metin Aktaş Özlem Yeşiltaş 《Journal of mathematical chemistry》2008,43(2):845-851
Exact solution of Schr?dinger equation for the pseudoharmonic potential is obtained for an arbitrary angular momentum. The
energy eigenvalues and corresponding eigenfunctions are calculated by Nikiforov–Uvarov method. Wavefunctions are expressed
in terms of Jacobi polynomials. The energy eigenvalues are calculated numerically for some values of ℓ and n with n ≤ 5 for some diatomic molecules.
相似文献
33.
Salgado EN Lewis RA Faraone-Mennella J Tezcan FA 《Journal of the American Chemical Society》2008,130(19):6082-6084
We have previously demonstrated that non-self-associating protein building blocks can oligomerize to form discrete supramolecular assemblies under the control of metal coordination. We show here that secondary interactions (salt bridges and hydrogen bonds) can be critical in guiding the metal-induced self-assembly of proteins. Crystallographic and hydrodynamic measurements on appropriately engineered cytochrome cb562 variants pinpoint the importance of a single salt-bridging arginine side chain in determining whether the protein monomers form a discrete Zn-induced tetrameric complex or heterogeneous aggregates. The combined ability to direct PPIs through metal coordination and secondary interactions should provide the specificity required for the construction of complex protein superstructures and the selective control of cellular processes that involve protein-protein association reactions. 相似文献
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Controlling the Structure and Length of Self‐Synthesizing Supramolecular Polymers through Nucleated Growth and Disassembly
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Dr. Asish Pal Dr. Morteza Malakoutikhah Giulia Leonetti Meniz Tezcan Mathieu Colomb‐Delsuc Dr. Van Duc Nguyen Prof. Jasper van der Gucht Prof. Sijbren Otto 《Angewandte Chemie (International ed. in English)》2015,54(27):7852-7856
Directing self‐assembly processes out‐of‐equilibrium to yield kinetically trapped materials with well‐defined dimensions remains a considerable challenge. Kinetically controlled assembly of self‐synthesizing peptide‐functionalized macrocycles through a nucleation–growth mechanism is reported. Spontaneous fiber formation in this system is effectively shut down as most of the material is diverted into metastable non‐assembling trimeric and tetrameric macrocycles. However, upon adding seeds to this mixture, well‐defined fibers with controllable lengths and narrow polydispersities are obtained. This seeded growth strategy also allows access to supramolecular triblock copolymers. The resulting noncovalent assemblies can be further stabilized through covalent capture. Taken together, these results show that self‐synthesizing materials, through their interplay between dynamic covalent bonds and noncovalent interactions, are uniquely suited for out‐of‐equilibrium self‐assembly. 相似文献
37.
Albert Kakkis Dr. Derek Gagnon Dr. Julian Esselborn Prof. R. David Britt Prof. F. Akif Tezcan 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(49):22124-22128
To mimic a hypothetical pathway for protein evolution, we previously tailored a monomeric protein (cyt cb562) for metal-mediated self-assembly, followed by re-design of the resulting oligomers for enhanced stability and metal-based functions. We show that a single hydrophobic mutation on the cyt cb562 surface drastically alters the outcome of metal-directed oligomerization to yield a new trimeric architecture, (TriCyt1)3. This nascent trimer was redesigned into second and third-generation variants (TriCyt2)3 and (TriCyt3)3 with increased structural stability and preorganization for metal coordination. The three TriCyt variants combined furnish a unique platform to 1) provide tunable coupling between protein quaternary structure and metal coordination, 2) enable the construction of metal/pH-switchable protein oligomerization motifs, and 3) generate a robust metal coordination site that can coordinate all mid-to-late first-row transition-metal ions with high affinity. 相似文献
38.
Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that involve ligand/metal-induced protein dimerization. 相似文献
39.
采用具有紫外光聚合性能的聚乙二醇(PEG)基水凝胶材料, 通过紫外光聚合作用快速加工双层水凝胶微流控芯片, 并验证了其对肿瘤细胞代谢液进行检测的可行性. 与传统微流控芯片材料相比, 该水凝胶芯片材料具有更好的生物相容性及可操控性, 可直接加工成形, 在生物学领域特别是细胞培养过程控制方面具有良好的应用前景. 实验结果表明, 该水凝胶微流控芯片可在微尺度空间有效模拟细胞生长环境, 并实现对细胞连续捕获后的原位培养. 将该芯片与卟啉可视阵列传感器系统结合, 经代谢特征分析可有效区分不同种类肿瘤细胞, 实现芯片细胞培养平台上的细胞代谢指纹快速可视化传感检测. 相似文献
40.
Rutherford backscattering and channeling spectrometry (RBS/C) are used to identify the crystalline quality (Xmin = 4.87%) Of an InN thin film as a function of depth, and make a non-destructive quantitative analysis of the structure, in order to analyze the tetragonal distortion of the InN thin film at the depth determined. 相似文献