全文获取类型
收费全文 | 104篇 |
免费 | 5篇 |
专业分类
化学 | 92篇 |
晶体学 | 1篇 |
力学 | 5篇 |
数学 | 3篇 |
物理学 | 8篇 |
出版年
2022年 | 1篇 |
2020年 | 1篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 1篇 |
2012年 | 11篇 |
2011年 | 8篇 |
2010年 | 5篇 |
2009年 | 7篇 |
2008年 | 15篇 |
2007年 | 14篇 |
2006年 | 12篇 |
2005年 | 7篇 |
2004年 | 3篇 |
2003年 | 2篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 4篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1986年 | 1篇 |
1980年 | 1篇 |
排序方式: 共有109条查询结果,搜索用时 309 毫秒
81.
Facially amphiphilic urea oligomers were successfully prepared in a one-pot reaction by carbonyl diimidazole (CDI) coupling and showed greater antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Bacillus subtilis than MSI-78. 相似文献
82.
Polymers based on meta substituted phenylene ethylene are prepared with patterned polar and nonpolar groups to favor an extended conformation. These polymers were characterized at the air-water interface by Langmuir techniques and found to form stable monolayers with an extended conformation based on molecular models. In addition, these polymers show phospholipid membrane activity as measured by induced leakage of calcein from large unilamellar vesicles. These polymers represent new facially amphiphilic structures which are cationic in nature and surface active. 相似文献
83.
Joel M. Sarapas Prof. Dr. Gregory N. Tew 《Angewandte Chemie (International ed. in English)》2016,55(51):15860-15863
A new use of the thiol‐ene reaction to generate functional, redox‐tunable polymers is described. To illustrate the versatility of this approach, tailored divinyl ether monomers were polymerized with triethylene glycol dithiol to yield polymers containing either a carbonate or zwitterionic phosphocholine within the polymer backbone. Similarly, dithioerythritol was polymerized with triethylene glycol divinyl ether to yield a polymer with pendant diols and show how functional groups can be designed into either the divinyl ether or dithiol monomer. Using the thioether functional group inherent to this polymerization, all three polymers were selectively and quantitatively oxidized to either sulfoxides or sulfones by treatment with dilute hydrogen peroxide or mCPBA, respectively. With these illustrative examples, it is shown that the thiol‐ene polymerization is a broad‐reaching method to access a class of new redox‐active polymers which contain varied and dense functional‐group compositions. 相似文献
84.
David E. Zacharias Jenny P. Glusker Kenneth D. Tew Beryl Hartley-Asp 《Structural chemistry》1995,6(6):371-376
Estramustine is an antimicrotubule agent that is effective against prostate cancer when used in combination with other microtubule-binding drugs. It is a derivative of estradiol and has a nitrogen mustard group attached via an intervening carbamate group. The molecular dimensions published for estramustine from crystal structure analyses (Mol. Pharmacol. 41∶569, 1992) indicate that the carbamate group modifies the mustard group by giving considerable double-bond character to the C-N bond. As a result the mustard group cannot form an active aziridine ring and therefore does not show the expected alkylating function. The substitution at O(3) of the aromatic A ring of the steroid moiety has also modified its activity as a steroid. Geometric data are presented here on a compound in which the two chlorine atoms of the mustard group of estramustine are replaced by hydroxyl groups. The question was, why does the dihydroxy derivative not show biological activity when chlorine atoms do not appear to be activated in estramustine itself? A comparison of the molecular geometries of the two compounds shows that the dimensions of the carbamate group are similar in both compounds. Therefore it appears that it is the extensive hydrogen-bonding capability of the dihydroxy compound that destroys its estramustine-like activity. In crystals of both compounds there is a hydrogen bond between O(17) -H and O(19) of another molecule, but the dihydroxy compound can form two more hydrogen bonds. This may possibly prevent it from reaching the site of action of estramustine or, if it does reach that site, cause it to behave differently. 相似文献
85.
86.
The promise of proteomics to provide a vast library of protein structural data is exciting to scientists desiring an unprecedented understanding of the relationship between protein structure and function. This powerful knowledge will provide insight into the design rules for proteomimetics which are oligomers and polymers that can be more stable and inexpensive to produce than natural proteins, but still emulate the main biological function of the natural molecule. This Emerging Area article is intended to stimulate discussion on innovative strategies to design the next generation of proteomimetics. Specifically we will examine the design evolution of facially amphiphilic aryl oligomers, compounds that act as synthetic mimics of antimicrobial peptides (SMAMPs) and are known to interact with lipid bilayers. An increasingly important goal in the field of antimicrobial polymers is to develop strategies to rationally design membrane-binding SMAMPs, that are highly cell-selective, from any preferred backbone and molecular weight. It is expected that lessons learned from studying these oligomers can be applied to other systems where mimics are desired to interact with extended surfaces and where it would be most productive to consider mimicking the protein of interest with a large molecule. Obvious examples include disrupting protein-protein interactions or binding long tracts of DNA to control gene expression. 相似文献
87.
The linear and polycatenar type 1H-imidazole amphiphiles showing a strong self-assembly tendency to build various supramolecular structures in bulk were synthesized by the esterification reaction of 4′-alkyloxy phenols (for 1-4) and hydroxyphenyl trialkyloxybenzoates (for 5-7) with 4-chlorocarbonyl imidazole. The linear 1H-imidazole amphiphiles formed thermotropic smectic phases, but compound 4 with an ethyl group instead of hydrogen on 1N did not show a mesophase. The polycatenar type 1H-imidazole amphiphiles (5-7) formed thermotropic hexagonal columnar and cubic phases. A phase transition was observed from a columnar phase to a cubic phase as the temperature increased on heating, and vice versa on cooling. In the POM study for compounds 5-7, optically isotropic phases first appeared on cooling from the isotropic melts, and then birefringent mesophases with a nonspecific texture appeared on further cooling. The X-ray analysis shows that the optically isotropic phases were very likely micellar cubic phases with Pm3n symmetry. The birefringent phases were confirmed as hexagonal columnar phases. 相似文献
88.
89.
Synthetic antimicrobial oligomers induce a composition-dependent topological transition in membranes 总被引:1,自引:0,他引:1
Yang L Gordon VD Mishra A Som A Purdy KR Davis MA Tew GN Wong GC 《Journal of the American Chemical Society》2007,129(40):12141-12147
Antimicrobial peptides (AMPs) are cationic amphiphiles that comprise a key component of innate immunity. Synthetic analogues of AMPs, such as the family of phenylene ethynylene antimicrobial oligomers (AMOs), recently demonstrated broad-spectrum antimicrobial activity, but the underlying molecular mechanism is unknown. Homologues in this family can be inactive, specifically active against bacteria, or nonspecifically active against bacteria and eukaryotic cells. Using synchrotron small-angle X-ray scattering (SAXS), we show that observed antibacterial activity correlates with an AMO-induced topological transition of small unilamellar vesicles into an inverted hexagonal phase, in which hexagonal arrays of 3.4-nm water channels defined by lipid tubes are formed. Polarized and fluorescence microscopy show that AMO-treated giant unilamellar vesicles remain intact, instead of reconstructing into a bulk 3D phase, but are selectively permeable to encapsulated macromolecules that are smaller than 3.4 nm. Moreover, AMOs with different activity profiles require different minimum threshold concentrations of phosphoethanolamine (PE) lipids to reconstruct the membrane. Using ternary membrane vesicles composed of DOPG:DOPE:DOPC with a charge density fixed at typical bacterial values, we find that the inactive AMO cannot generate the inverted hexagonal phase even when DOPE completely replaces DOPC. The specifically active AMO requires a threshold ratio of DOPE:DOPC = 4:1, and the nonspecifically active AMO requires a drastically lower threshold ratio of DOPE:DOPC = 1.5:1. Since most gram-negative bacterial membranes have more PE lipids than do eukaryotic membranes, our results imply that there is a relationship between negative-curvature lipids such as PE and antimicrobial hydrophobicity that contributes to selective antimicrobial activity. 相似文献
90.
Drew SC Leong SL Pham CL Tew DJ Masters CL Miles LA Cappai R Barnham KJ 《Journal of the American Chemical Society》2008,130(24):7766-7773
The interaction of the small (140 amino acid) protein, alpha-synuclein (alphaS), with Cu(2+) has been proposed to play a role in Parkinson's disease (PD). While some insight from truncated model complexes has been gained, the nature of the corresponding Cu(2+) binding modes in the full length protein remains comparatively less well characterized. This work examined the Cu(2+) binding of recombinant human alphaS using Electron Paramagnetic Resonance (EPR) spectroscopy. Wild type (wt) alphaS was shown to bind stoichiometric Cu(2+) via two N-terminal binding modes at physiological pH. An H50N mutation isolated one binding mode, whose g parallel, A parallel, and metal-ligand hyperfine parameters correlated well with a {NH2, N(-), beta-COO(-), H2O} mode previously identified in truncated model fragments. Electron spin-echo envelope modulation (ESEEM) studies of wt alphaS confirmed the second binding mode at pH 7.4 involved coordination of His50 and its g parallel and A parallel parameters correlated with either {NH2, N(-), beta-COO(-), N(Im)} or {N(Im), 2 N(-)} coordination observed in alphaS fragments. At pH 5.0, His50-anchored Cu(2+) binding was greatly diminished, while {NH2, N(-), beta-COO(-), H2O} binding persisted in conjunction with another two binding modes. Metal-ligand hyperfine interactions from one of these indicated a 1N3O coordination sphere, which was ascribed to a {NH2, CO} binding mode. The other was characterized by a spectrum similar to that previously observed for diethylpyrocarbonate-treated alphaS and was attributed to C-terminal binding centered on Asp121. In total, four Cu(2+) binding modes were identified within pH 5.0-7.4, providing a more comprehensive picture of the Cu(2+) binding properties of recombinant alphaS. 相似文献