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81.
For a general nonlinear system and closed target set we study the value functions and
of the control problems of reaching and, respectively, its interior, in minimum time. Under no controllability assumptions on the system, we characterize them as, respectively, the minimal viscosity supersolution and the maximal viscosity subsolution of the Bellman equation with appropriate boundary conditions. Then we prove that
is the unique upper semicontinuous complete solution of such a boundary value problem, which means in particular that the (completed) graph of
contains the graph of any solution, as well as all the limits of reasonable approximating sequences. We give some applications to verifications theorems and to the stability of the minimum time function with respect to general perturbations.The authors are partially supported by the Italian National Projects Equazioni di evoluzione e applicazioni fisico-matematiche and Equazioni differenziali e calcolo delle variazioni, respectively. 相似文献
82.
Snezana D. Nikolic Teodora D. Jankovi Emil B. Milosavljevi James L. Hendrix John H. Nelson 《Fresenius' Journal of Analytical Chemistry》1992,342(1-2):98-102
Summary A rapid, indirect diffusion flow injection analysis (FIA) method with amperometric detection has been developed for the selective and sensitive determination of Br–. The method is based on permanganate oxidation of Br– to bromine. Bromine diffuses through a PTFE membrane and is quantified amperometrically at a platinum working electrode. Calibration graphs were linear up to the maximum concentration of Br– investigated (10.0 mmol/l). The precision of the technique was better than a relative standard deviation of 0.7% at 10.0 mol/l, with a throughput of 30 samples per hour. The effects of temperature, acidity, working potential, composition of the reagent solution and interferents on the FIA signals were studied. The catalytic effect of Cl– on the permanganate oxidation of the analyte was utilized to lower the detection limit to 1 mol/l (16 ng Br–). Similar detection limits were achieved by combining the effects of higher acidity (4.0 mol/l H2SO4) and elevated temperatures (40°C). The method was successfully applied to the determination of Br– in chloride and other reagents, as well as in natural waters. 相似文献
83.
Georgi Stavrakov Irena Philipova Atanas Lukarski Mariyana Atanasova Borislav Georgiev Teodora Atanasova Spiro Konstantinov Irini Doytchinova 《Molecules (Basel, Switzerland)》2021,26(7)
Despite extensive and intensive research efforts in recent decades, there is still no effective treatment for neurodegenerative diseases. On this background, the use of drugs inhibiting the enzyme acetylcholinesterase (AChE) remains an eternal evergreen in the symptomatic treatment of mild to moderate cognitive impairments. Even more, the cholinergic hypothesis, somewhat forgotten in recent years due to the shift in focus on amyloid cascade, is back to life, and the search for new, more effective AChE inhibitors continues. We generated a fragment-based library containing aromatic moieties and linkers originating from a set of novel AChE inhibitors. We used this library to design 1220 galantamine (GAL) derivatives following the model GAL (binding core) - linker (L) - aromatic fragment (Ar). The newly designed compounds were screened virtually for blood–brain barrier (BBB) permeability and binding to AChE. Among the top 10 best-scored compounds, a representative lead molecule was selected and tested for anti-AChE activity and neurotoxicity. It was found that the selected compound was a powerful non-toxic AChE inhibitor, 68 times more active than GAL, and could serve as a lead molecule for further optimization and development. 相似文献
84.
Simion Bogdan Angyus Erika Levei Dorin Petreus Radu Etz Eniko Covaci Oana Teodora Moldovan Michaela Ponta Eugen Darvasi Tiberiu Frentiu 《Molecules (Basel, Switzerland)》2021,26(9)
The simultaneous determination of chemical vapor-generating elements involving derivatization is difficult even by inductively coupled plasma optical emission spectrometry or mass spectrometry. This study proposes a new direct liquid microsampling method for the simultaneous determination of As, Bi, Se, Te, Hg, Pb, and Sn, using a fully miniaturized set-up based on electrothermal vaporization capacitively coupled plasma microtorch optical emission spectrometry. The method is cost-effective, free from non-spectral interference, and easy to run by avoiding derivatization. The method involves the vaporization of analytes from the 10 µL sample and recording of episodic spectra generated in low-power (15 W) and low-Ar consumption (150 mL min−1) plasma microtorch interfaced with low-resolution microspectrometers. Selective vaporization at 1300 °C ensured the avoidance of non-spectral effects and allowed the use of external calibration. Several spectral lines for each element even in the range 180–210 nm could be selected. Generally, this spectral range is examined with large-scale instrumentation. Even in the absence of derivatization, the obtained detection limits were low (0.02–0.75 mg kg−1) and allowed analysis of environmental samples, such as cave and river sediments. The recovery was in the range of 86–116%, and the accuracy was better than 10%. The method is of general interest and could be implemented on any miniaturized or classical laboratory spectrometric instrumentation. 相似文献
85.
Dynamics equations of a mobile robot provided with caster wheel 总被引:1,自引:0,他引:1
Stefan Staicu 《Nonlinear dynamics》2009,58(1-2):237-248
Kinematics and dynamics of a mobile robot, consisting of a platform, two conventional wheels and a crank that controls the motion of a free rolling caster wheel, are analyzed in the paper. Based on several matrix relations of connectivity, the characteristic velocities and accelerations of this non-holonomic mechanical system are derived. Using the principle of virtual work, expressions and graphs for the torques and the powers of the two driving wheels are established. It has been verified the results in the framework of the second-order Lagrange equations with their multipliers. The study of the dynamics problems of the wheeled mobile robots is done mainly to solve successfully the control of the motion of such systems. 相似文献
86.
Corentin Bon Yang Si Melanie Pernak Magdalena Barbachowska Eva Levi-Acobas Veronique Cadet Daniel Corinne Jallet Dusan Ruzic Nemanja Djokovic Teodora Djiki Katarina Nikolic Ludovic Halby Paola B. Arimondo 《Molecules (Basel, Switzerland)》2021,26(17)
Histone methyltransferase DOT1L catalyzes mono-, di- and trimethylation of histone 3 at lysine residue 79 (H3K79) and hypermethylation of H3K79 has been linked to the development of acute leukemias characterized by the MLL (mixed-lineage leukemia) rearrangements (MLLr cells). The inhibition of H3K79 methylation inhibits MLLr cells proliferation, and an inhibitor specific for DOT1L, pinometostat, was in clinical trials (Phase Ib/II). However, the compound showed poor pharmacological properties. Thus, there is a need to find new potent inhibitors of DOT1L for the treatment of rearranged leukemias. Here we present the design, synthesis, and biological evaluation of a small molecule that inhibits in the nM level the enzymatic activity of hDOT1L, H3K79 methylation in MLLr cells with comparable potency to pinometostat, associated with improved metabolic stability and a characteristic cytostatic effect. 相似文献
87.
Shikha Dhiman Teodora Andrian Beatriz Santiago Gonzalez Marrit M. E. Tholen Yuyang Wang Lorenzo Albertazzi 《Chemical science》2022,13(8):2152
The characterization of newly synthesized materials is a cornerstone of all chemistry and nanotechnology laboratories. For this purpose, a wide array of analytical techniques have been standardized and are used routinely by laboratories across the globe. With these methods we can understand the structure, dynamics and function of novel molecular architectures and their relations with the desired performance, guiding the development of the next generation of materials. Moreover, one of the challenges in materials chemistry is the lack of reproducibility due to improper publishing of the sample preparation protocol. In this context, the recent adoption of the reporting standard MIRIBEL (Minimum Information Reporting in Bio–Nano Experimental Literature) for material characterization and details of experimental protocols aims to provide complete, reproducible and reliable sample preparation for the scientific community. Thus, MIRIBEL should be immediately adopted in publications by scientific journals to overcome this challenge. Besides current standard spectroscopy and microscopy techniques, there is a constant development of novel technologies that aim to help chemists unveil the structure of complex materials. Among them super-resolution microscopy (SRM), an optical technique that bypasses the diffraction limit of light, has facilitated the study of synthetic materials with multicolor ability and minimal invasiveness at nanometric resolution. Although still in its infancy, the potential of SRM to unveil the structure, dynamics and function of complex synthetic architectures has been highlighted in pioneering reports during the last few years. Currently, SRM is a sophisticated technique with many challenges in sample preparation, data analysis, environmental control and automation, and moreover the instrumentation is still expensive. Therefore, SRM is currently limited to expert users and is not implemented in characterization routines. This perspective discusses the potential of SRM to transition from a niche technique to a standard routine method for material characterization. We propose a roadmap for the necessary developments required for this purpose based on a collaborative effort from scientists and engineers across disciplines.SRM, an advanced nanoscopy technique demands a transition from being a niche sophisticated technique to standard routine method for material characterization. The roadmap of necessary developments through multidisciplinary collaboration is discussed. 相似文献
88.
Andra Dinache Simona Nistorescu Tatiana Tozar Adriana Smarandache Mihai Boni Petronela Prepelita Angela Staicu 《Molecules (Basel, Switzerland)》2023,28(1)
This study presents the spectral characterization of TiO2 nanoparticles (NPs) functionalized with three porphyrin derivatives: 5,10,15,20-(Tetra-4-aminophenyl) porphyrin (TAPP), 5,10,15,20-(Tetra-4-methoxyphenyl) porphyrin (TMPP), and 5,10,15,20-(Tetra-4-carboxyphenyl) porphyrin (TCPP). UV-Vis absorption and Fourier transform infrared spectroscopy–attenuated total reflection (FTIR-ATR) spectroscopic studies of these porphyrins and their complexes with TiO2 NPs were performed. In addition, the efficiency of singlet oxygen generation, the key species in photodynamic therapy, was investigated. UV-Vis absorption spectra of the NPs complexes showed the characteristic bands of porphyrins. These allowed us to determine the loaded porphyrins on TiO2 NPs functionalized with porphyrins. FTIR-ATR revealed the formation of porphyrin-TiO2 complexes, suggesting that porphyrin adsorption on TiO2 may involve the pyrroles in the porphyrin ring, or the radicals of the porphyrin derivative. The quantum yield for singlet oxygen generation by the studied porphyrin complexes with TiO2 was higher compared to bare porphyrins for TAPP and TMPP, while for the TCPP-TiO2 NPs complex, a decrease was observed, but still maintained a good efficiency. The TiO2 NPs conjugates can be promising candidates to be tested in photodynamic therapy in vitro assays. 相似文献
89.
Wanner J Bail S Jirovetz L Buchbauer G Schmidt E Gochev V Girova T Atanasova T Stoyanova A 《Natural product communications》2010,5(9):1355-1358
Cumin oil samples (Cuminum cyminum L.) from four different geographical origins were analyzed using GC-MS and GC-FID for their qualitative and quantitative composition. The major compounds in all cumin oils were the monoterpenes beta-pinene, p-cymene and gamma-terpinene and the terpenoid aldehydes cuminic aldehyde and the isomeric menthadien carboxaldehydes. All essential oils, and cuminic aldehyde, were tested, using agar diffusion and serial dilution methods, against different Gram-positive and Gram-negative bacteria isolated from different sources of food (pork fillet, minced meat and sausages) and clinical isolates, as well as three different Candida albicans isolates. All cumin oils and cuminic aldehyde exhibited a considerable inhibitory effect against all the organisms tested, except Pseudomonas spp. 相似文献
90.
Wanner J Schmidt E Bail S Jirovetz L Buchbauer G Gochev V Girova T Atanasova T Stoyanova A 《Natural product communications》2010,5(9):1349-1354
The chemical compositions of selected essential oils from North Africa, especially Morocco, of geranium, wild Moroccan chamomile and rosemary as well as absolutes of rose and geranium were determined using GC/FID and GC/MS. These oils and absolutes were tested concerning their antimicrobial activity against some food spoilage strains obtained from fresh milk and minced meat products, like sausages and pork fillet, in accordance with ISO testing procedures. Gram-positive (Bacillus cereus and Staphylococcus aureus) and Gram-negative (Escherichia coli, Salmonella abony and Pseudomonas aeruginosa) strains were used, as well as the yeast Candida albicans. Using a serial broth dilution method, all samples demonstrated weak antimicrobial activity against the Gram-negative bacteria and the yeast, compared with the activity towards the Gram-positive bacteria. 相似文献