全文获取类型
收费全文 | 1594篇 |
免费 | 79篇 |
国内免费 | 9篇 |
专业分类
化学 | 1289篇 |
晶体学 | 5篇 |
力学 | 9篇 |
数学 | 141篇 |
物理学 | 238篇 |
出版年
2023年 | 28篇 |
2022年 | 39篇 |
2021年 | 49篇 |
2020年 | 62篇 |
2019年 | 59篇 |
2018年 | 44篇 |
2017年 | 25篇 |
2016年 | 55篇 |
2015年 | 34篇 |
2014年 | 55篇 |
2013年 | 69篇 |
2012年 | 148篇 |
2011年 | 170篇 |
2010年 | 62篇 |
2009年 | 44篇 |
2008年 | 102篇 |
2007年 | 110篇 |
2006年 | 95篇 |
2005年 | 95篇 |
2004年 | 75篇 |
2003年 | 55篇 |
2002年 | 45篇 |
2001年 | 13篇 |
2000年 | 7篇 |
1999年 | 5篇 |
1998年 | 9篇 |
1997年 | 9篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 4篇 |
1991年 | 7篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 10篇 |
1983年 | 2篇 |
1982年 | 7篇 |
1981年 | 14篇 |
1980年 | 9篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1977年 | 9篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1973年 | 7篇 |
1971年 | 1篇 |
1964年 | 1篇 |
1896年 | 1篇 |
排序方式: 共有1682条查询结果,搜索用时 187 毫秒
991.
A. Paden King Sierra C. Marker Robert V. Swanda Joshua J. Woods Prof. Shu-Bing Qian Prof. Justin J. Wilson 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(39):9206-9210
Complexes of the element Re have recently been shown to possess promising anticancer activity through mechanisms of action that are distinct from the conventional metal-based drug cisplatin. In this study, we report our investigations on the anticancer activity of the complex [Re(CO)3(dmphen)(p-tol-ICN)]+ (TRIP) in which dmphen=2,9-dimethyl-1,10-phenanthroline and p-tol-ICN=para-tolyl isonitrile. TRIP was synthesized by literature methods and exhaustively characterized. This compound exhibited potent in vitro anticancer activity in a wide variety of cell lines. Flow cytometry and immunostaining experiments indicated that TRIP induces intrinsic apoptosis. Comprehensive biological mechanistic studies demonstrated that this compound triggers the accumulation of misfolded proteins, which causes endoplasmic reticulum (ER) stress, the unfolded protein response, and apoptotic cell death. Furthermore, TRIP induced hyperphosphorylation of eIF2α, translation inhibition, mitochondrial fission, and expression of proapoptotic ATF4 and CHOP. These results establish TRIP as a promising anticancer agent based on its potent cytotoxic activity and ability to induce ER stress. 相似文献
992.
993.
994.
995.
996.
Keun-il Kim Qiubo Guo Longteng Tang Liangdong Zhu Changqing Pan Prof. Chih-hung Chang Joshua Razink Prof. Michael M. Lerner Prof. Chong Fang Prof. Xiulei Ji 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(45):20096-20100
Oxidative anion insertion into graphite in an aqueous environment represents a significant challenge in the construction of aqueous dual-ion batteries. In dilute aqueous electrolytes, the oxygen evolution reaction (OER) dominates the anodic current before anions can be inserted into the graphite gallery. Herein, we report that the reversible insertion of Mg-Cl superhalides in graphite delivers a record-high reversible capacity of 150 mAh g−1 from an aqueous deep eutectic solvent comprising magnesium chloride and choline chloride. The insertion of Mg-Cl superhalides in graphite does not form staged graphite intercalation compounds; instead, the insertion of Mg-Cl superhalides makes the graphite partially turbostratic. 相似文献
997.
Luther Wang Alexander B. Elliott Prof. Sean D. Moore Prof. Gregory J. O. Beran Prof. Joshua D. Hartman Prof. James K. Harper 《Chemphyschem》2021,22(10):1008-1017
The ability to theoretically predict accurate NMR chemical shifts in solids is increasingly important due to the role such shifts play in selecting among proposed model structures. Herein, two theoretical methods are evaluated for their ability to assign 15N shifts from guanosine dihydrate to one of the two independent molecules present in the lattice. The NMR data consist of 15N shift tensors from 10 resonances. Analysis using periodic boundary or fragment methods consider a benchmark dataset to estimate errors and predict uncertainties of 5.6 and 6.2 ppm, respectively. Despite this high accuracy, only one of the five sites were confidently assigned to a specific molecule of the asymmetric unit. This limitation is not due to negligible differences in experimental data, as most sites exhibit differences of >6.0 ppm between pairs of resonances representing a given position. Instead, the theoretical methods are insufficiently accurate to make assignments at most positions. 相似文献
998.
Marziyeh E. Kenari Joshua I. Putman Ravi P. Singh Brandon B. Fulton Huy Phan Reem K. Haimour Key Tse Alain Berthod Carl J. Lovely Daniel W. Armstrong 《Molecules (Basel, Switzerland)》2021,26(1)
Twelve new azole compounds were synthesized through an ene reaction involving methylidene heterocycles and phenylmaleimide, producing four oxazoles, five thiazoles, and one pyridine derivative, and ethyl glyoxylate for an oxazole and a thiazole compound. The twelve azoles have a stereogenic center in their structure. Hence, a method to separate the enantiomeric pairs, must be provided if any further study of chemical and pharmacological importance of these compounds is to be accomplished. Six chiral stationary phases were assayed: four were based on macrocyclic glycopeptide selectors and two on linear carbohydrates, i.e., derivatized maltodextrin and amylose. The enantiomers of the entire set of new chiral azole compounds were separated using three different mobile phase elution modes: normal phase, polar organic, and reversed phase. The most effective chiral stationary phase was the MaltoShell column, which was able to separate ten of the twelve compounds in one elution mode or another. Structural similarities in the newly synthesized oxazoles provided some insights into possible chiral recognition mechanisms. 相似文献
999.
1000.