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571.
da Silveira Géssica Domingos Bressan Lucas Panes Schmidt Marcella Emilia Petra Dal Molin Thaís Ramos Teixeira Carlos Alberto Poppi Ronei Jesus da Silva José Alberto Fracassi 《Journal of Solid State Electrochemistry》2020,24(8):1999-2010
Journal of Solid State Electrochemistry - Evaluation of electrochemical behavior of 5-type phosphodiesterase inhibitory drugs is of major concern since they have been added illegally as adulterants... 相似文献
572.
Milene Lopes da Silva Róbson Ricardo Teixeira Fabrício Marques de Oliveira Luciano de Moura Guimarães Felipe Terra Martins 《Journal of heterocyclic chemistry》2021,58(3):777-792
Compounds containing a pyran moiety fused to two cyclohexen-2-one rings are collectively called xanthenodiones (1,8-dioxooctahydroxanthenes). With the aim of increasing the knowledge about the structures of xanthenodiones, in the present investigation two xanthenodiones, namely 9-(4-hydroxy-3-methoxyphenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione ( 1 ) and 9-(4-hydroxyphenyl)-3,6-diisopropyl 3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione ( 2 ), were synthesized. Their structures were investigated by nuclear magnetic resonance, single-crystal X-ray diffraction, infrared (IR), and Raman spectroscopy techniques along with mass spectrometry. In addition, a computational study was carried out involving vibrational spectroscopy, which allowed us to assign vibrational modes and their shifts as lattice environment. Even though compound 2 has two stereocenters, it crystallized in a centrosymmetric space group (P21/c) as expected from its achiral synthesis. This compound also crystallized as monohydrate and the presence of water molecule did not change the conformation of the target compounds. 相似文献
573.
Luana R. Michels Flvia N.S. Fachel Juliana H. Azambuja Nicolly E. Gelsleichter Elizandra Braganhol Helder F. Teixeira 《Biomedical chromatography : BMC》2019,33(10)
A high‐performance liquid chromatography method for temozolomide (TMZ) determination in complex biological matrices was developed and validated for application in in vitro, ex vivo and in vivo studies of new nanotechnology‐based systems for TMZ nasal delivery. The method was able to quantify TMZ in nanoemulsions, following cellular uptake, in the porcine nasal mucosa and in mouse plasma and brain. Analyses were performed on a C18 column at 35°C, under UV detection at 330 nm. The mobile phase was methanol–acetic acid 0.5% (30:70, v/v), eluted at an isocratic flow rate of 1.1 mL/min. The method was found to be specific, precise, accurate, robust and linear (0.05 to 5 μg/mL) for TMZ determination in all matrices. No interference of TMZ degradation products was found under various stress conditions such as acidic, alkaline, oxidative, light and thermal exposure, demonstrating stability. The method was applied for the quantification of TMZ in different matrices, i.e. the efficiency of nanoemulsions in vitro in increasing TMZ cellular uptake, ex vivo TMZ permeation and retention in the porcine nasal mucosa tissue, and for in vivo TMZ quantification in mouse brain following intranasal nanoemulsion administration compared with free TMZ. 相似文献
574.
Graziela Teixeira de Oliveira Paula Avelar Amado Jaqueline Maria Siqueira Ferreira 《Natural product research》2019,33(16):2402-2407
Lippia alba, belonging to the Verbenaceae family, is one of the most commonly utilized medicinal plants in folk medicine. The allelopathic activity was assessed using seeds of Lactuca sativa (lettuce) and Allium cepa (onion) by assessing the growth of the radicle and hypocotyl. The tests showed allelopathic efficiency in inhibiting the growth of lettuce and onion seeds. The best results for allelopathic activity were presented by the dichloromethane (DCM) fraction of the fresh plant, which inhibited radicle (23.04–100% lettuce and 64.17–66.36% onion) and hypocotyl (16.77–100% lettuce and 65.10–69.43% onion) formation, and as well as the DCM fraction of the dry plant, which also inhibited radicle (30.74–82.83% lettuce and 63.50–93.67% onion) and hypocotyl (24.12–70% lettuce and 69.07–79.95% onion) formation. Based on these results, it was found that the aerial parts of L. alba are rich in bioactive substances, suggesting the possibility of using of L. alba as a natural herbicide. 相似文献
575.
576.
This paper is concerned with a geometric study of ()‐parameter families of constrained differential systems, where . Our main results say that the dynamics of such a family close to the impasse set is equivalent to the dynamics of a multiple time scale singular perturbation problem (that is a singularly perturbed system containing several small parameters). This enables us to use a geometric theory for multiscale systems in order to describe the behaviour of such a family close to the impasse set. We think that a systematic program towards a combination between geometric singular perturbation theory and constrained systems and problems involving persistence of typical minimal sets are currently emergent. Some illustrations and applications of the main results are provided. 相似文献
577.
Ana Carolina Corrêa Eliangela de Morais Teixeira Luiz Antonio Pessan Luiz Henrique Capparelli Mattoso 《Cellulose (London, England)》2010,17(6):1183-1192
Curaua nanofibers extracted under different conditions were investigated. The raw fibers were mercerized with NaOH solutions;
they were then submitted to acid hydrolysis using three different types of acids (H2SO4, a mixture of H2SO4/HCl and HCl). The fibers were analyzed by cellulose, lignin and hemicellulose contents; viscometry, X-ray diffraction (XRD)
and thermal stability by thermogravimetric analysis (TG). The nanofibers were morphologically characterized by transmission
electron microscopy (TEM) and their surface charges in suspensions were estimated by Zeta-potential. Their degree of polymerization
(DP) was characterized by viscometry, crystallinity by XRD and thermal stability by TG. Increasing the NaOH solution concentration
in the mercerization, there was a decrease of hemicellulose and lignin contents and consequently an increase of cellulose
content. XRD patterns presented changes in the crystal structure from cellulose I to cellulose II when the fibers were mercerized
with 17.5% NaOH solution. All curaua nanofibers presented a rod-like shape, an average diameter (D) of 6–10 nm and length
(L) of 80–170 nm, with an aspect ratio (L/D) of around 13–17. The mercerization of fibers with NaOH solutions influenced the
crystallinity index and thermal stability of the resulting nanofibers. The fibers mercerized with NaOH solution 17.5% resulted
in more crystalline nanofibers, but thermally less stable and inferior DP. The aggregation state increases with the amount
of HCl introduced into the extraction, due to the decrease of surface charges (as verified by Zeta Potential analysis). However,
this release presented nanofibers with better thermal stability than those whose acid hydrolysis was carried out using only
H2SO4. 相似文献
578.
Sara C. Silvério Oscar Rodríguez José A. Teixeira Eugénia A. Macedo 《The Journal of chemical thermodynamics》2010,42(8):1063-1069
The Gibbs free energy of transfer of a suitable hydrophobic probe can be regarded as a measure of the relative hydrophobicity of the different phases. The methylene group (CH2) can be considered hydrophobic, and thus be a suitable probe for hydrophobicity. In this work, the partition coefficients of a series of five dinitrophenylated-amino acids were experimentally determined, at 23 °C, in three different tie-lines of the biphasic systems: (UCON + K2HPO4), (UCON + potassium phosphate buffer, pH 7), (UCON + KH2PO4), (UCON + Na2HPO4), (UCON + sodium phosphate buffer, pH 7), and (UCON + NaH2PO4). The Gibbs free energy of transfer of CH2 units were calculated from the partition coefficients and used to compare the relative hydrophobicity of the equilibrium phases. The largest relative hydrophobicity was found for the ATPS formed by dihydrogen phosphate salts. 相似文献
579.