Diastereoselective access to nonracemic 2-cis-substituted and 2,6-cis-disubstituted piperidines

Access to nonracemic amino ketones via a hydrozirconation/transmetalation/acylation sequence applied to Boc-protected 1-aminobut-3-enes is presented. This method was applied to the stereoselective synthesis of cyclic imines (or iminiums) which were diastereoselectively converted into 2-cis-substituted and 2,6-cis-disubstituted piperidines. The potential of this approach in the field of alkaloid synthesis was illustrated by the synthesis of (-)-coniine and (-)-indolizidine 209D. Furthermore, access to indolizidines bearing a quaternary center could also be envisioned through this strategy.     

Practicality of the cyclotron production of radiolanthanide 142Pr: a potential for therapeutic applications and biodistribution studies

Radiolanthanide praseodymium-142 (T _1/2 = 19.12 h, E _?? ^?  = 2.162 MeV (96.3%), E?? = 1575 keV (3.7%)) due to its high ??-emission and low specific ??-emission could not only be a therapeutic radionuclide, but also a suitable radionuclide in order for biodistribution studies. Conventionally, ¹⁴²Pr produces via ¹⁴¹Pr(n,??)¹⁴²Pr reaction by irradiation in a low-fluence reactor and this study evaluates cyclotron reaction production of it. ¹⁴²Pr excitation function via ^natLa(??,n)¹⁴²Pr, ¹⁴²Ce(p,n)¹⁴²Pr, and ^natPr(d,p)¹⁴²Pr reactions were calculated by TALYS-1.2 and EMPIRE-2.19beta codes, and with the data taken from the TENDL-2010 database. In addition, we compared them with the reported measurement by experimental data. Requisite thickness of targets was obtained by SRIM-2010 code for each reaction. The ¹⁴²Pr production yield was evaluated with attention to excitation function and stopping power. Similar to reactor produced ¹⁴²Pr; ¹⁴¹Pr impurity exists in cyclotron produced ¹⁴²Pr while it could not be separated by chemical methods. Therefore, cyclotron and reactor produced ¹⁴²Pr will be in carrier added form.     

Application of N-thiocyanatosuccinimide as a reagent for the facile conversion of epoxides into thiocyanohydrines

The use of in situ generated N-thiocyanatosuccinimide with NH₄SCN offers an efficient reagent system for the conversion of epoxides into their corresponding thiocyanohydrines in good to high yields.The major advantages of this method are as follows:use of cheap reagent,high regioselectivity,simple availability of reagent,ease of workup of the reaction.     

Nonlinear anisotropic parabolic equations in with locally integrable data

In this paper, we prove existence and regularity of weak solutions for a class of nonlinear anisotropic parabolic problems in with locally integrable data. Our approach is based on the anisotropic Sobolev inequality, a smoothness, and compactness results. Copyright © 2012 John Wiley & Sons, Ltd.     

Entanglement transfer via XXZ Heisenberg chain with DM interaction

The role of spin-orbit interaction arises from the Dzyaloshinskii-Moriya anisotropic antisymmetric interaction on the entanglement transfer via an antiferromagnetic XXZ Heisenberg chain is investigated. From symmetrical point of view the XXZ Hamiltonian with Dzyaloshinskii-Moriya interaction can be replaced by a modified XXZ Hamiltonian which is defined by a new exchange coupling constant and rotated Pauli operators. The modified coupling constant and the angle of rotations depend on the strength of Dzyaloshinskii-Moriya interaction. In this paper we study the dynamical behavior of the entanglement propagation through a system which is consist of a pair of maximally entangled spins coupled to one end of the chain. The calculations are performed for the ground state and the thermal state of the chain separately. In both cases the presence of this anisotropic interaction make our channel more efficient. We show for large values of the strength of this interaction a large family of XXZ chains becomes efficient quantum channels for whole values of anisotropy parameter in the region −2 ≤ Δ ≤ 2.     

Dichloroimidazolidinedione-activated one-pot Suzuki–Miyaura cross-coupling of phenols

The first general method for the Suzuki-type cross-coupling of phenols with aryl boronic acids using dichloroimidazolidinedione (DCID) as a new reagent is presented. In the presence of DCID and Pd/metal–organic framework (MOF), coupling of aryl boronic acids with a wide range of phenols, was carried out smoothly in tetrahydrofuran (THF) at reflux conditions to afford the cross-coupling products in good to excellent yields. The structures of all compounds were corroborated by ¹H- and ¹³C-NMR. A plausible mechanism for this type of reaction is proposed.     

Exact identities for sessile drops

By direct integration of the Young-Laplace relation, a set of identities are presented for the axisymmetric sessile drops on flat and curved substrates. The geometrical parameters, including the apex curvature, the apex height, and the contact radius, are related by the identities. The validity of the identities is checked by various numerical solutions for drops on flat and curved substrates.     

Impact of Long‐Wavelength Ultraviolet A1 and Visible Light on Light‐Skinned Individuals

Solar radiation is known to be a major contributor to the development of skin cancer. Most sunscreen formulations, including those with broad spectrum, offer minimal protection in long‐wavelength ultraviolet A1 (UVA1; 370–400 nm) and visible light (VL; 400–700 nm) domain. There is limited information regarding the impact of this broad waveband (VL + UVA1, 370–700 nm) on those with light skin. In this study, ten healthy adult subjects with Fitzpatrick skin phototypes I–III were enrolled. On day 0, subjects' lower back was exposed to a VL + UVA1 dose of 480 J cm^?2. A statistically significant increase in erythema immediately after irradiation compared with subjects' baseline nonirradiated skin was observed. Clinically perceptible erythema with VL + UVA1 is a novel finding since the erythemogenic spectrum of sunlight has primarily been attributed to ultraviolet B and short‐wavelength ultraviolet A (320–340 nm). The results emphasize the need for protection against this part of the solar spectra and warrant further investigation.     

Two magnetic regimes in doped ZnO corresponding to a dilute magnetic semiconductor and a dilute magnetic insulator

Films of ZnO doped with magnetic ions Mn and Co and, in some cases, with Al have been fabricated with a very wide range of carrier densities. Ferromagnetic behavior is observed in both insulating and metallic films, but not when the carrier density is intermediate. Insulating films exhibit variable range hopping at low temperatures and are ferromagnetic at room temperature due to the interaction of the localized spins with static localized states. The magnetism is quenched when carriers in the localized states become mobile. In the metallic (degenerate semiconductor) range, robust ferromagnetism reappears together with very strong magneto-optic signals and room temperature anomalous Hall data. This demonstrates the polarization of the conduction bands and indicates that, when ZnO is doped into the metallic regime, it behaves as a genuine magnetic semiconductor.