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991.
G Abbiati A Arcadi M Chiarini F Marinelli E Pietropaolo E Rossi 《Organic & biomolecular chemistry》2012,10(38):7801-7808
A new one-pot approach was developed to construct the 11H-indolo[3,2-c]quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new protocol as well as the mild and neutral reaction conditions make it a viable alternative to the previously reported procedures. 相似文献
992.
Demoro B Sarniguet C Sánchez-Delgado R Rossi M Liebowitz D Caruso F Olea-Azar C Moreno V Medeiros A Comini MA Otero L Gambino D 《Dalton transactions (Cambridge, England : 2003)》2012,41(5):1534-1543
In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasites, and particularly against African Trypanosomiasis, whose etiological agent is Trypanosoma brucei, organoruthenium compounds with bioactive nitrofuran containing thiosemicarbazones (L) as co-ligands were obtained. Four ruthenium(II) complexes with the formula [Ru(2)(p-cymene)(2)(L)(2)]X(2), where X = Cl or PF(6), were synthesized and the crystal structures of two of them were solved by X-ray diffraction methods. Two of the complexes show significant in vitro growth inhibition activity against Trypanosoma brucei brucei and are highly selective towards trypanosomal cells with respect to mammalian cells (J774 murine macrophages). These promising results make the title organoruthenium compounds good lead candidates for further developments towards potential antitrypanosomal organometallic drugs. 相似文献
993.
The evolution of a myrmecophilous lifestyle in beetles is often associated with morphological alterations. In particular, the antennae of all members of the myrmecophilous ground beetle tribe Paussini are greatly modified, with flagellomeres flattened or crassate, frequently reduced in number from 9 to 5 or even 1 single “antennal club”. The enhanced glandular function of the antennal club has been recently described by scanning (SEM) and transmission (TEM) electron microscopy in Paussus favieri Fairmaire, 1851, where the antenna has become a complex glandular organ, supplying rewarding substances to the ants. In the present work, the antennal sensilla of P. favieri are investigated by SEM, TEM and focused ion beam (FIB/SEM) technology. Most sensilla of scape and antennal club are highly modified mechanoreceptors (i.e. multipointed, fringed, branched, brush-like, sickle-shaped), singly or grouped in tufts (“antennal symphilous organs”). These “trichomes”, here assigned to 8 different morphotypes of sensilla chaetica (Ch.1–Ch.8), show a variable number of basal pores (present also at the base of the taste sensilla Ch.9), which spread dense substances of unknown chemical composition on the seta. Although hygro-, thermo- and chemoreceptors are reduced in number as compared with non-myrmecophilous relatives, and mainly relegated to the apex of the antennal club, their diversity is comparable to that of other carabid beetles: two types of sensilla trichodea (Tr.1–Tr.2); three types of basiconica (Ba.1–Ba.3); one type of campaniformia (Ca); one type of coeloconica (Co) and one type of Böhm sensilla (Bo). Contrary to the hypothesis that Paussus species lack a Johston's organ, a non-connective chordotonal organ composed of 9 groups of scolopidia has been found inside the pedicel. A comparison between sensilla of P. favieri and those of other non-myrmecophilous and myrmecophilous ground beetle species is provided. 相似文献
994.
We found that the absorption spectra of 2-acetylphenol (2-HAP), 4-acetylphenol (4-HAP), and p-nitrophenol (p-NPh) in water/sodium 1,4-bis(2-ethylhexyl)sulfosuccinate (AOT)/n-heptane reverse micelles (RMs) at various W(0) (W(0) = [H(2)O]/[surfactant]) values studied changed with time if (-)OH ions were present in the RM water pool. There is an evolution of ionized phenol (phenolate) bands to nonionized phenol absorption bands with time and this process is faster at low W(0) values and with phenols with higher bulk water pK(a) values. That is, in bulk water and at the hydroxide anion concentration used, only phenolate species are observed, whereas in AOT RMs at this fixed hydroxide anion concentration, ionized phenols convert into nonionized phenol species over time. Furthermore, we demonstrate that, independent of the (-)OH concentration used to prepare the AOT RMs, the nonionized phenols are the more stable species in the RM media. We explain our results by considering that strong hydrogen-bonding interactions between phenols and the AOT polar head groups result in the existence of only nonionized phenols at the AOT RM interface. The situation is quite different when the phenols are dissolved in cationic benzyl-n-hexadecyldimethylammonium chloride RMs. Therein, only phenolates species are present at the (-)OH concentrations used. The results clearly demonstrate that the classical definition of pH does not apply in a confined environment, such as in the interior of RMs and challenge the general idea that pH can be determined inside RMs. 相似文献
995.
S Roy A Willinger S Combrié A De Rossi G Eisenstein M Santagiustina 《Optics letters》2012,37(14):2919-2921
We predict narrowband parametric amplification in dispersion-tailored photonic crystal waveguides made of gallium indium phosphide. We use a full-vectorial model including the dispersive nature both of the nonlinear response and of the propagation losses. An analytical formula for the gain is also derived. 相似文献
996.
Nissilä T Sainiemi L Karikko MM Kemell M Ritala M Franssila S Kostiainen R Ketola RA 《Lab on a chip》2011,11(8):1470-1476
We developed a nanoreactor chip based system to mimic phase I metabolic reactions of small organic compounds. The microchip, made of silicon, has an anatase-phase titanium dioxide (TiO(2)) nanolayer coating for photocatalysis and an integrated electrospray ionization (ESI) tip for direct mass spectrometric (MS) analysis. This novel method for mimicking phase I metabolic reactions uses an on-chip TiO(2)-nanolayer and an external UV-lamp to induce photocatalyzed chemical reactions of drug compounds in aqueous solutions. The reactions of selected test compounds (verapamil, metoprolol, propranolol, lidocaine, 2-acetamidofluorene, and S-methylthiopurine) produced mostly the same main products as phase I metabolic reactions induced by human liver microsomes, rat hepatocytes, or cytochrome P enzymes, showing hydroxylation, dehydrogenation, and dealkylations as the main photocatalytic reactions. With this method it is possible to detect reactive and toxic products (mimicking reactive metabolites) due to the absence of biological matrices and an immediate analysis. The method used is sensitive: only 20-40 pmol (1-10 ng) of a substrate was needed for the experiment, thus it provides an inexpensive method for screening possible metabolites of new drug candidates. Due to small dimensions of the microchip, diffusion lengths are suitable for the high reaction rates, thus providing a rapid analysis as the reaction products can be detected and identified directly after the photoinduced reactions have occurred. The method shows a similar performance to that of electrochemistry, a commonly used technique for mimicking phase I metabolism. 相似文献
997.
Tricas H Colon M Ellis D Macgregor SA McKay D Rosair GM Welch AJ Glukhov IV Rossi F Laschi F Zanello P 《Dalton transactions (Cambridge, England : 2003)》2011,40(16):4200-4211
The icosahedral carboranes 1-C(6)F(5)-2-Ph-1,2-closo-C(2)B(10)H(10) (1), 1-(4'-F(3)CC(6)H(4))-2-Ph-1,2-closo-C(2)B(10)H(10) (2), 1,2-(4'-F(3)CC(6)H(4))(2)-1,2-closo-C(2)B(10)H(10) (3), 1-(4'-H(3)CC(6)F(4))-2-Ph-1,2-closo-C(2)B(10)H(10) (4), 1-(4'-F(3)CC(6)F(4))-2-Ph-1,2-closo-C(2)B(10)H(10) (5), 1,2-(4'-F(3)CC(6)F(4))(2)-1,2-closo-C(2)B(10)H(10) (6), 1,7-(4'-F(3)CC(6)F(4))(2)-1,7-closo-C(2)B(10)H(10) (7) and 1,12-(4'-F(3)CC(6)F(4))(2)-1,12-closo-C(2)B(10)H(10) (8), with fluorinated aryl substituents on cage carbon atoms, have been prepared in good to high yields and characterised by microanalysis, (1)H, (11)B and (19)F NMR spectroscopies, mass spectrometry, single-crystal X-ray diffraction and (spectro)electrochemistry. By analysis of <δ(11)B>, the weighted average (11)B chemical shift, a ranking order for the ortho carboranes 1-6 is established based on the combined electron-withdrawing properties of the C-substituents, and is in perfect agreement with that established independently by electrochemical study. In a parallel computational study the effects of a wide range of different substituents on the redox properties of carboranes have been probed by comparison of ΔE values, where ΔE is the energy gap between the DFT-optimised [7,9-R(2)-7,9-nido-C(2)B(10)](2-) anion and its DFT-optimised basket-shaped first oxidation product. The overall conclusion from the NMR spectroscopic, electrochemical and computational studies is that strongly electron withdrawing substituents significantly stabilise [7,9-nido-C(2)B(10)](2-) dianions with respect to oxidation, and that the best practical substituent is 4-F(3)CC(6)F(4). Thus attention focussed on the reduction of 1,2-(4'-F(3)CC(6)F(4))(2)-1,2-closo-C(2)B(10)H(10), compound 6. The sequence 6/[6](-)/[6](2-) appears reversible on the cyclic voltammetric timescale but on the longer timescale of macroelectrolysis the radical anion is only partially stable. EPR study of the electrogenerated monoanions from the ortho-carboranes 1-6 confirms the cage-centred nature of the redox processes. In contrast, the reduction of the meta- and para-carboranes 7 and 8, respectively, appears to be centred on the aromatic substituents, a conclusion supported by the results of DFT calculation of the LUMOs of compounds 6-8. Bulk 2-electron reduction of 6 affords a dianion which is remarkably stable to reoxidation, surviving for several hours in the open laboratory in the absence of halogenated solvents. 相似文献
998.
Carbonylation of styrenes catalyzed by bioxazoline Pd(II) complexes: mechanism of enantioselectivity
Carfagna C Gatti G Mosca L Natanti P Paoli P Rossi P Gabriele B Salerno G 《Dalton transactions (Cambridge, England : 2003)》2011,40(25):6792-6801
Preliminary studies of the elementary steps involved in the reaction of a chiral methyl carbonyl bioxazoline Pd(II) complex with aromatic olefins and CO have allowed development of a new enantioselective catalytic carbonylation process, leading to γ-ketoester derivatives with high yield and good enantiomeric excess. The intermediate palladacycle complexes have been isolated and characterized by NMR spectroscopy and X-ray diffraction. Factors that govern the stereoselectivity of the olefin carbonylation process are discussed. 相似文献
999.
The development of Micro Air Vehicles with flapping wings is inspired from the observation and study of natural flyers such
as insects and birds. This article explores the rotational power consumption of a flapping wing using a mechanical flapper
at Re ≃ 4,500. This mechanical flapper is simplified to a 2D translation and a rotation in a water tank. Moreover, the wing kinematics
are reduced to a linear translation and a rotation for the purpose of our study. We introduce the notion of non-ideal flapper
and associated non-ideal rotational power. Such non-ideal devices are defined as consuming power for adding and removing mechanical
power to and from the flow, respectively. First, we use a traditional symmetrical wing kinematic which is a simplified kinematic
inspired from natural flyers. The lift coefficient of this flapping is about C
L ≃ 1.5. This symmetrical wing kinematic is chosen as a reference. Further, wing kinematics with asymmetric rotations are then
compared with this one. These new kinematics are built using a differential velocity defined according to the translational
kinematics, a time lag and a distance, r
kp. The analogy of this distance is discussed as a key point to follow along the chord. First, the wing kinematics are varied
keeping a similar shape for the profiles of the angular velocity. It is shown that when compared to the reference wing kinematic,
a 10% reduction in the rotational power is obtained whilst the lift is reduced by 9%. Second, we release the limitation to
a similar shape for the profiles of the angular velocity leading to a novel shape for the angular velocity profile named here
as “double bump” profile. With these new wing kinematics, we show that a 60% reduction in the non-ideal rotational power can
be achieved whilst the lift coefficient is only reduced by 1.7%. Such “double bump kinematics” could then be of interest to
increase the endurance of Micro Air Vehicles. 相似文献
1000.
Riccarda Rossi Tomáš Roubí?ek 《Nonlinear Analysis: Theory, Methods & Applications》2011,74(10):3159-3190
We address a model for adhesive unilateral frictionless Signorini-type contact between bodies of heat-conductive viscoelastic material, in the linear Kelvin-Voigt rheology, undergoing thermal expansion. The flow rule for debonding the adhesion is considered rate-independent and unidirectional, and a thermodynamically consistent model is derived and analysed as far as the existence of a weak solution is concerned. 相似文献