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971.
B. Fornal R. Broda W. Królas T. Pawlat J. Wrzesiński D. Bazzacco S. Lunardi C. Rossi Alvarez G. Viesti G. de Angelis M. Cinausero D. Napoli J. Gerl E. Caurier F. Nowacki 《The European Physical Journal A - Hadrons and Nuclei》2000,7(2):147-148
In-beam γ-rays in neutron-rich sdfp shell nuclei, produced in deep-inelastic collisions of 48Ca projectiles on 48Ca target nuclei, have been studied using Ge multidetector array EU-ROBALL III. New yrast states in heavy argon isotopes have
been identified.
Received: 11 November 1999 相似文献
972.
973.
Anran Shi Han Zheng Zhiyi Chen Wei Zhang Xiang Zhou Carole Rossi Ruiqi Shen Yinghua Ye 《Molecules (Basel, Switzerland)》2022,27(11)
The effect of the interface layer on energy release in nanoenergetic composite films is important and challenging for the utilization of energy. Nano Al/CuO composite films with different modulation periods were prepared by magnetron sputtering and tested by differential scanning calorimetry. With the increase in the modulation period of the nano Al/CuO energetic composite films, the interface layer contained in the energetic composite film decreased meaningfully, increasing the total heat release meaningfully. Ab initio molecular dynamics (AIMD) simulation were carried out to study the preparation process changes and related properties of the nano Al/CuO energetic composite films under different configurations at 400 K. The results showed that the diffusion of oxygen atoms first occurred at the upper and lower interfaces of CuO and Al, forming AlOx and CuxAlyOz. The two-modulation-period structure changed more obviously than the one-modulation-period structure, and the reaction was faster. The propagation rate and reaction duration of the front end of the diffusion reaction fronts at the upper and lower interfaces were different. The Helmholtz free energy loss of the nano Al/CuO composite films with a two-modulation-period configuration was large, and the number of interfacial layers had a great influence on the Helmholtz free energy, which was consistent with the results of the thermal analysis. Current molecular dynamics studies may provide new insights into the nature and characteristics of fast thermite reactions in atomic detail. 相似文献
974.
Maria Consiglia Trotta Francesco Petrillo Carlo Gesualdo Settimio Rossi Alberto Della Corte Judit Vradi Ferenc Fenyvesi Michele DAmico Anca Hermenean 《Molecules (Basel, Switzerland)》2022,27(15)
Diabetic retinopathy (DR) is a neurovascular disease characterized by the reduction of retina integrity and functionality, as a consequence of retinal pigment epithelial cell fibrosis. Although galectin-1 (a glycan-binding protein) has been associated with dysregulated retinal angiogenesis, no evidence has been reported about galectin-1 roles in DR-induced fibrosis. ARPE-19 cells were cultured in normal (5 mM) or high glucose (35 mM) for 3 days, then exposed to the selective galectin-1 inhibitor OTX008 (2.5–5–10 μM) for 6 days. The determination of cell viability and ROS content along with the analysis of specific proteins (by immunocytochemistry, Western blotting, and ELISA) or mRNAs (by real time-PCR) were performed. OTX008 5 μM and 10 μM improved cell viability and markedly reduced galectin-1 protein expression in cells exposed to high glucose. This was paralleled by a down-regulation of the TGF-β/, NF-kB p65 levels, and ROS content. Moreover, epithelial–mesenchymal transition markers were reduced by OTX008 5 μM and 10 μM. The inhibition of galectin-1 by OTX008 in DR may preserve retinal pigment epithelial cell integrity and functionality by reducing their pro-fibrotic phenotype and epithelial–mesenchymal transition phenomenon induced by diabetes. 相似文献
975.
Anna Tesei Michela Cortesi Martina Bedeschi Noemi Marino Giacomo Rossino Roberta Listro Daniela Rossi Pasquale Linciano Simona Collina 《Molecules (Basel, Switzerland)》2022,27(14)
Different pathological conditions, including viral infections and cancer, can have a massive impact on the endoplasmic reticulum (ER), causing severe damage to the cell and exacerbating the disease. In particular, coronavirus infections, including SARS coronavirus-2 (SARS-CoV-2), responsible for COVID-19, cause ER stress as a consequence of the enormous amounts of viral glycoproteins synthesized, the perturbation of ER homeostasis and the modification of ER membranes. Therefore, ER has a central role in the viral life cycle, thus representing one of the Achilles’ heels on which to focus therapeutic intervention. On the other hand, prolonged ER stress has been demonstrated to promote many pro-tumoral attributes in cancer cells, having a key role in tumor growth, metastasis and response to therapies. In this report, adopting a repurposing approach of approved drugs, we identified the antiplatelet agent ticlopidine as an interferent of the unfolded protein response (UPR) via sigma receptors (SRs) modulation. The promising results obtained suggest the potential use of ticlopidine to counteract ER stress induced by viral infections, such as COVID-19, and cancer. 相似文献
976.
Aggie Lawer James A. Rossi‐Ashton Thomas C. Stephens Bradley J. Challis Ryan G. Epton Jason M. Lynam William P. Unsworth 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(39):14080-14085
A strategy for the synthesis of medium‐sized lactones and lactams from linear precursors is described in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/ring expansion cascade sequence. This method obviates the need for the high‐dilution conditions usually associated with medium‐ring cyclisation protocols, as the reactions operate exclusively via kinetically favourable “normal”‐sized cyclic transition states. This same feature also enables biaryl‐containing medium‐sized rings to be prepared with complete atroposelectivity by point‐to‐axial chirality transfer. 相似文献
977.
Jörg M. Stockmann Jörg Radnik Sebastian Bütefisch Ingo Busch Thomas Weimann Cristiana Passiu Antonella Rossi Wolfgang E.S. Unger 《Surface and interface analysis : SIA》2020,52(12):890-894
Small-area/spot photoelectron spectroscopy (SAXPS) is a powerful tool for the investigation of small surface features like microstructures of electronic devices, sensors or other functional surfaces, and so forth. For evaluating the quality of such microstructures, it is often crucial to know whether a small signal in a spectrum is an unwanted contamination of the field of view (FoV), defined by the instrument settings, or it originated from outside. To address this issue, the d80/20 parameter of a line scan across a chemical edge is often used. However, the typical d80/20 parameter does not give information on contributions from the long tails of the X-ray beam intensity distribution or the electron-optical system as defined by apertures. In the VAMAS TWA2 A22 project “Applying planar, patterned, multi-metallic samples to assess the impact of analysis area in surface-chemical analysis,” new test specimen was developed and tested. The here presented testing material consists of a silicon wafer substrate with an Au-film and embedded Cr circular and square spots with decreasing dimensions from 200 μm down to 5 μm. The spot sizes are traceable to the length unit due to size measurements with a metrological SEM. For the evaluation of the FoV, we determined the Au4f intensities measured with the center of the FoV aligned with the center of the spot and normalized to the Au4f intensity determined on the Au-film. With this test specimen, it was possible to characterize, as an example, the FoV of a Kratos AXIS Ultra DLD XPS instrument. 相似文献
978.
Mossini Eros Codispoti Luca Parma Giorgio Rossi Filippo Maria Macerata Elena Porta Alessandro Campi Fabrizio Mariani Mario 《Journal of Radioanalytical and Nuclear Chemistry》2019,322(3):1341-1350
Journal of Radioanalytical and Nuclear Chemistry - Since its shutdown in 1979, L-54M nuclear research reactor of Politecnico di Milano has been kept in safe storage configuration. In view of... 相似文献
979.
Giuliana Ferrante Rossana Rossi Giovanna Cilluffo Dario Di Silvestre Andrea Brambilla Antonella De Palma Chiara Villa Velia Malizia Rosalia Gagliardo Yvan Torrente Giovanni Corsello Giovanni Viegi Pierluigi Mauri Stefania La Grutta 《Molecules (Basel, Switzerland)》2021,26(5)
Urine proteomic applications in children suggested their potential in discriminating between healthy subjects from those with respiratory diseases. The aim of the current study was to combine protein fractionation, by urinary extracellular vesicle isolation, and proteomics analysis in order to establish whether different patterns of respiratory impedance in healthy preschoolers can be characterized from a protein fingerprint. Twenty-one 3–5-yr-old healthy children, representative of 66 recruited subjects, were selected: 12 late preterm (LP) and 9 full-term (T) born. Children underwent measurement of respiratory impedance through Forced Oscillation Technique (FOT) and no significant differences between LP and T were found. Unbiased clustering, based on proteomic signatures, stratified three groups of children (A, B, C) with significantly different patterns of respiratory impedance, which was slightly worse in group A than in groups B and C. Six proteins (Tripeptidyl peptidase I (TPP1), Cubilin (CUBN), SerpinA4, SerpinF1, Thy-1 membrane glycoprotein (THY1) and Angiopoietin-related protein 2 (ANGPTL2)) were identified in order to type the membership of subjects to the three groups. The differential levels of the six proteins in groups A, B and C suggest that proteomic-based profiles of urinary fractionated exosomes could represent a link between respiratory impedance and underlying biological profiles in healthy preschool children. 相似文献
980.
Dr. Stefano Amatori Dr. Gianluca Ambrosi Dr. Mirco Fanelli Dr. Mauro Formica Prof. Vieri Fusi Dr. Luca Giorgi Dr. Eleonora Macedi Dr. Mauro Micheloni Prof. Paola Paoli Dr. Roberto Pontellini Dr. Patrizia Rossi Maria Antonietta Varrese 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(14):4274-4284
Ligand L (4‐(7‐nitrobenzo[1,2,5]oxadiazole‐4‐yl)‐1,7‐dimethyl‐1,4,7,10‐tetra‐azacyclododecane) is a versatile fluorescent sensor useful for CuII, ZnII and CdII metal detection, as a building block of fluorescent metallo‐receptor for halide detection, and as an organelle marker inside live cells. Ligand L undergoes a chelation‐enhanced fluorescence (CHEF) effect upon metal coordination in acetonitrile solution. In all three complexes investigated the metal cation is coordinatively unsaturated; thus, it can bind secondary ligands as anionic species. The crystal structure of [Zn L Cl](ClO4) is discussed. CuII and ZnII complexes are quenched upon halide interaction, whereas the [Cd L ]2+ species behaves as an OFF–ON sensor for halide anions in acetonitrile solution. The mechanism of the fluorescence response in the presence of the anion depends on the nature of the metal ion employed and has been studied by spectroscopic methods, such as NMR spectroscopy, UV/Vis and fluorescence techniques and by computational methods. Subcellular localization experiments performed on HeLa cells show that L mainly localizes in spot‐like structures in a polarized portion of the cytosol that is occupied by the Golgi apparatus to give a green fluorescence signal. 相似文献