Carbonylation of C−N Bonds in Tertiary Amines Catalyzed by Low‐Valent Iron Catalysts

The first iron catalysts able to promote the formal insertion of CO into the C?N bond of amines are reported. Using low‐valent iron complexes, including K₂[Fe(CO)₄], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl₃ and Nd(OTf)₃, have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars).     

Determination of Fenofibric Acid in Human Plasma by LC–MS/MS and LC–UV

A sensitive, high-throughput and economic liquid chromatographic method for determination of fenofibric acid in human plasma was developed and validated by ultraviolet detection and tandem mass spectrometry, then applied in pharmacokinetic study to investigate Lipanthyl™ 200 mg MC bioavailability under food and fasting conditions. Fenofibric acid with 2-chloro fenofibric acid-d6 (internal standard) was extracted from 100 µL of human plasma by acetonitrile in a single extraction step. 25 and 2 µL from supernatant were injected onto ACE column, 50 mm, 5 micron with 4.6 mm inner diameter for LC–UV and 2.1 mm for LC–MS/MS, and both systems were eluted isocratically by water:methanol:formic acid (35:65:0.1, v/v/v), with a constant flow rate of 1 mL min⁻¹. The established calibration curve was linear between 0.05–20 µg mL⁻¹, and the within- and between-day precisions were all below 13 % in both LC–MS/MS and LC–UV systems during validation, and accuracies ranged between 91 and 112 %. Twenty-eight healthy adult subjects participated in this clinical study, and the pharmacokinetic parameters including coefficient of variation were calculated and discussed. A dramatic decrease in C _max and AUC0-72 (3.63- and 1.85-fold, respectively) were observed for Lipanthyl™ MC under fasting conditions with more variable inter subject measurements comparing to the fed state.

     

Optimization and effect of wall conduction on natural convection in a cavity with constant temperature heat source: Using lattice Boltzmann method and neural network algorithm

Journal of Thermal Analysis and Calorimetry - In this paper, the natural convection (NC) of the Al2O3–H2O nanofluids (NFs) in a cavity with a heat source in its center is numerically...     

Heat transfer analysis in the flow of Walters' B fluid with a convective boundary condition

Radiative heat transfer in the steady two-dimensional flow of Walters' B fluid with a non-uniform heat source/sink is investigated. An incompressible fluid is bounded by a stretching porous surface. The convective boundary condition is used for the thermal boundary layer problem. The relevant equations are first simplified under usual boundary layer assumptions and then transformed into a similar form by suitable transformations. Explicit series solutions of velocity and temperature are derived by the homotopy analysis method(HAM). The dimensionless velocity and temperature gradients at the wall are calculated and discussed.     

Design,Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates

The increasing prevalence of microbial infections and the emergence of resistance to the currently available antimicrobial drugs urged the development of potent new chemical entities with eminent pharmacokinetic and/or pharmacodynamic profiles. Thus, a series of new indole-triazole conjugates 6a-u was designed and synthesized to be assessed as new antimicrobial candidates using the diameter of the inhibition zone and minimum inhibitory concentration assays against certain microbial strains. Their in vitro antibacterial evaluation revealed good to moderate activity against most of the tested Gram-negative strains with diameter of the inhibition zone (DIZ) values in the range of 11–15 mm and minimum inhibition concentration (MIC) values around 250 µg/mL. Meanwhile, their in vitro antifungal evaluation demonstrated a potent activity against Candida tropicalis with MIC value as low as 2 µg/mL for most of the tested compounds. Moreover, compound 6f is the most potent congener with an MIC value of 2 µg/mL against Candida albicans.     

Simplicity of the Lie Algebra of Skew Symmetric Elements of a Leavitt Path Algebra

For a field F of characteristic not 2 and a directed row-finite graph Γ let L(Γ) be the Leavitt Path Algebra with standard involution *. We study the lie algebra of K = K(L(Γ), *) of * ?skew-symmetric elements and find necessary and sufficient conditions for the Lie algebra [K, K] to be simple.     

Double injection–single detector flow injection spectrophotometric method for simultaneous determination of ascorbic acid and paracetamol in pharmaceutical formulations

Journal of the Iranian Chemical Society - A simple and low-cost flow injection spectrophotometric method was proposed for the simultaneous determination of ascorbic acid (AA) and paracetamol (PCM)...