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51.
W. Tate 《Fresenius' Journal of Analytical Chemistry》1891,30(1):312
Ohne Zusammenfassung 相似文献
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C. C. Coffin G. Grinling F. G. H. Tate 《Analytical and bioanalytical chemistry》1935,102(5-6):198-199
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The performance of back-propagation artificial neural networks (NN) and partial least squares (PLS) regression for the calibration of linear and nonlinear systems has been investigated by using six types of synthetic data. Three PLS methods, conventional linear-PLS and two nonlinear-PLS methods, have been used in the study. In all but one of the synthetic data types, the band intensities varied nonlinearly with concentration. These five data types were designed to represent the effect of band shifts with increasing concentration, a nonlinear relationship between peak height and concentration, or a combination of both types of nonlinearities. The results showed that NNs perform better than PLS for all the nonlinear datasets. When a band shift is the major reason for the nonlinearity, the relative performance of NNs and PLS depends on the overlap of the absorption bands. If there is no band overlap, neither NN nor PLS can calibrate the data accurately but the results could be improved by convolving the spectral features with a Gaussian broadening function. The results indicate that a combination of peak position shift and peak height change is the most difficult nonlinearity to calibrate. NN and PLS were also used to determine the concentration of CHCl3 in pure component and mixtures of CHCl3 and CH2Cl2 using their Fourier transform infrared (FT-IR) spectra, a dataset that has been proved nonlinear in high concentrations due to the nonlinear response of the detector. The best results for the experimental data were obtained by applying one hidden layer NN to the mean-centered absorbance spectra. 相似文献
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Main W. Carmel Y. Ogura K. Weaver J. Nusinovich G.S. Kobayashi S. Tate J.P. Rodgers J. Bromborsky A. Watanabe S. Amin M.R. Minami K. Destler W.W. Granatstein V.L. 《IEEE transactions on plasma science. IEEE Nuclear and Plasma Sciences Society》1994,22(5):566-577
Specific slow wave structures are needed in order to produce coherent Cherenkov radiation in overmoded relativistic generators. The electromagnetic characteristics of such slow wave, resonant, finite length structures commonly used in relativistic backward wave oscillators have been studied both experimentally and theoretically. In experiments, perturbation techniques were used to study both the fundamental and higher order symmetric transverse magnetic (TM) modes. Finite length effects lead to end reflections and quantization of the wave number. The effects of end reflections in open slow wave structures were found from the spectral broadening of the discrete resonances of the different axial modes. The measured axial and radial field distributions are in excellent agreement with the results of a 2-D code developed for the calculation of the fields in these structures 相似文献
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Heal WP Wickramasinghe SR Bowyer PW Holder AA Smith DF Leatherbarrow RJ Tate EW 《Chemical communications (Cambridge, England)》2008,(4):480-482
N-Myristoyl transferase-mediated modification with azide-bearing substrates is introduced as a highly selective and practical method for in vitro and in vivo N-terminal labelling of a recombinant protein using bioorthogonal ligation chemistry. 相似文献
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Heal WP Wickramasinghe SR Leatherbarrow RJ Tate EW 《Organic & biomolecular chemistry》2008,6(13):2308-2315
N-Myristoyl transferase-mediated labelling using a substrate modified with an azide or alkyne tag is described as an efficient and site-selective method for the introduction of a bioorthogonal tag at the N-terminus of a recombinant protein. The procedure may be performed in vitro, or in a single over-expression/tagging step in vivo in bacteria; tagged proteins may then be captured using Staudinger-Bertozzi or 'click' chemistry protocols to introduce a secondary label for downstream analysis. The straightforward synthesis of the chemical and molecular biological tools described should enable their use in a wide range of N-terminal labelling applications. 相似文献
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Dr. Daniel Conole Dr. Fangyuan Cao Dr. Christopher W. am Ende Dr. Liang Xue Sheila Kantesaria Dr. Dahye Kang Jun Jin Dr. Dafydd Owen Dr. Linda Lohr Dr. Monica Schenone Dr. Jaimeen D. Majmudar Prof. Dr. Edward W. Tate 《Angewandte Chemie (International ed. in English)》2023,62(47):e202311190
Deubiquitinases (DUBs) are a family of >100 proteases that hydrolyze isopeptide bonds linking ubiquitin to protein substrates, often leading to reduced substrate degradation through the ubiquitin proteasome system. Deregulation of DUB activity has been implicated in many diseases, including cancer, neurodegeneration and auto-inflammation, and several have been recognized as attractive targets for therapeutic intervention. Ubiquitin-derived covalent activity-based probes (ABPs) provide a powerful tool for DUB activity profiling, but their large recognition element impedes cellular permeability and presents an unmet need for small molecule ABPs which can account for regulation of DUB activity in intact cells or organisms. Here, through comprehensive chemoproteomic warhead profiling, we identify cyanopyrrolidine (CNPy) probe IMP-2373 ( 12 ) as a small molecule pan-DUB ABP to monitor DUB activity in physiologically relevant live cells. Through proteomics and targeted assays, we demonstrate that IMP-2373 quantitatively engages more than 35 DUBs across a range of non-toxic concentrations in diverse cell lines. We further demonstrate its application to quantification of changes in intracellular DUB activity during pharmacological inhibition and during MYC deregulation in a model of B cell lymphoma. IMP-2373 thus offers a complementary tool to ubiquitin ABPs to monitor dynamic DUB activity in the context of disease-relevant phenotypes. 相似文献