Top‐down proteomics with a quadrupole time‐of‐flight mass spectrometer and collision‐induced dissociation

With slight modifications of the instrumental parameters, we demonstrate that satisfactory top‐down data can be obtained with collision‐induced dissociation (CID) tandem mass spectrometry on a quadrupole time‐of‐flight (qTOF) instrument not originally designed for this purpose. Protein identification is achieved with both N‐ and C‐terminal sequence tags and BLAST database searches. The accurate mass measurement of multiply charged fragment ions (mostly y and b‐type) supplements the limited set of cleavage sites and provides a high degree of sequence coverage (90–100%). Post‐translational modification issues can be addressed too. This approach might help those mass spectrometry (MS) core facilities that are not able to afford very high‐resolution instruments, thus expanding the benefits of top‐down protein analysis over the worldwide MS community. Copyright © 2009 John Wiley & Sons, Ltd.     

Crystal structure and optical spectra of LiLa9(SiO4)6O2 crystals activated with Er3+

LiLa₉(SiO₄)₆O₂ (LLS) crystals activated with Er³⁺ have been grown by the flux growth method. Their apatite structure has been characterized by single-crystal X-ray diffraction. The absorption and emission spectra have been measured in the visible and NIR regions. They are affected by a significant inhomogeneous broadening making these crystals interesting active media for tunable solid-state laser operation.     

Integrated structural approach to Credit Value Adjustment

This paper proposes an integrated pricing framework for Credit Value Adjustment of equity and commodity products. The given framework, in fact, generates dependence endogenously, allows for calibration and pricing to be based on the same numerical schemes (up to Monte Carlo simulation), and also allows the inclusion of risk mitigation clauses such as netting, collateral and initial margin provisions. The model is based on a structural approach which uses correlated Lévy processes with idiosyncratic and systematic components; the pricing numerical scheme, instead, efficiently combines Monte Carlo simulation and Fourier transform based methods. We illustrate the tractability of the proposed framework and the performance of the proposed numerical scheme by means of a case study on a portfolio of commodity swaps using real market data.     

On Euler–Jaczewski sequence and Remmert–Van de Ven problem for toric varieties

Let X be a complete toric variety and Y a smooth projective variety with . We prove that, if is a surjective morphism then . Received: 15 May 2001; in final form: 22 October 2001/ Published online: 4 April 2002     

Central potentials with closed cruise orbits

A particle will be said to be in cruise motion if it is nonholonomically constrained to have constant speed. When the particle is placed in a central force field, the resulting mechanical system is known to be integrable. Cruise orbits in a central force field may be closed (periodic in time) or not, depending on the potential and on the speed. Here we give a constructive characterization of all central potentials for which all cruise motions of a given speed are closed. As a consequence, we also give a new proof of the fact that for any such potential the set of speeds for which all cruise motions are closed has always empty interior.     

Independence logic and abstract independence relations

We continue the work on the relations between independence logic and the model‐theoretic analysis of independence, generalizing the results of 15 to the framework of abstract independence relations for an arbitrary AEC. We give a model‐theoretic interpretation of the independence atom and characterize under which conditions we can prove a completeness result with respect to the deductive system that axiomatizes independence in team semantics and statistics.     

Approximation by means of nonlinear Kantorovich sampling type operators in Orlicz spaces

In this paper we introduce a nonlinear version of the Kantorovich sampling type series in a nonuniform setting. By means of the above series we are able to reconstruct signals (functions) which are continuous or uniformly continuous. Moreover, we study the problem of the convergence in the setting of Orlicz spaces: this allows us to treat signals which are not necessarily continuous. Our theory applies to L^p-spaces, interpolation spaces, exponential spaces and many others. Several graphical examples are provided.     

3‐D viscous Cahn–Hilliard equation with memory

We deal with the memory relaxation of the viscous Cahn–Hilliard equation in 3‐D, covering the well‐known hyperbolic version of the model. We study the long‐term dynamic of the system in dependence of the scaling parameter of the memory kernel ε and of the viscosity coefficient δ. In particular we construct a family of exponential attractors, which is robust as both ε and δ go to zero, provided that ε is linearly controlled by δ. Copyright © 2008 John Wiley & Sons, Ltd.     

On some Fano manifolds of large pseudoindex

In this paper we classify pairs (X,ℰ) with ℰ ample vector bundle of rank r on a smooth variety X of dimension n= 2r−1 such that K _X + det ℰ=? _x . Received: 7 April 2000