基于三维简并四波混频的PDT光敏剂HA瞬态光栅特性研究

竹红菌甲素(hypocrellin A,HA)具有丰富的激发态特性,有可能在新型光动力疗法(PDT)光敏剂、激光染料和新型光电器件方面有一定的应用前景。利用瞬态光栅技术研究了竹红菌甲素分别在不同极性和粘度溶剂中以及溶剂本身的瞬态光栅特性,把其瞬态光栅的超快过程归结为竹红菌甲素质子转移形成的过渡态TS*的衰减,得出过渡态TS*瞬态光栅的寿命为10.5 ps。竹红菌甲素分子的质子转移过渡态TS*瞬态光栅寿命不受溶剂极性和粘度的影响。     

大气风场探测萨尼亚克干涉仪光程差的计算及探测模式研究

提出了基于时空混合调制的大气风场探测模式;应用光线追迹方法推导了一种改型萨尼亚克干涉仪在任意角入射时的光程差;从理论上对该干涉仪的参量作了分析计算;通过对同种、异种材料组合的理论分析,得出了异种材料组合的改型萨尼亚克干涉仪更加适合高层大气风场探测。该干涉仪具有稳态、大视场、大光程差、时空混合调制探测模式等显著特点。该研究发展了高层大气风场的被动探测理论,对风场探测技术研究、探测模式和工程化都具有十分重大的理论及实践意义。     

Experimental Study of Hygrothermal and Ultraviolet Aging on the Flexural Performance of Epoxy Polymer Mortar

This paper studies the effects of hygrothermal environment at different tempera-tures and ultraviolet(UV)radiation on the bending properties of epoxy polymer mo...     

会聚光在柱状模拟生物组织中的实验研究

在中空的柱状有机玻璃中充入Intralipid-10%溶液构成单层圆柱模拟样品.在会聚单色光入射Intralipid-10%溶液的情况下,利用特制的光纤探头、锁相放大器、斩波器和微动平台等组成测试装置,测量了柱状Intralipid-10%溶液内后向散射光、能流率的空间分布情况,并对测量结果进行分析.对参量不同的溶液中的光分布进行了比较,得出了柱状溶液中光分布的初步规律.     

二维导电金属有机骨架材料

金属有机骨架(MOFs)是由金属离子或簇与有机配体以配位键组装而成的晶态多孔材料,其高的孔隙率及功能可设计性使其广泛应用于各种领域.然而,传统MOFs多数电导率非常低,这严重制约了其在电学相关领域的发展.近年来,导电金属有机骨架尤其是二维导电金属有机骨架(2D ECMOFs)材料因其结构中独特的π-π堆积及π-d共轭作...     

Photocatalytic Carboxylation of Phenyl Halides with CO2 by Metal-Organic Frameworks Materials

In this work,important commercial pharmaceutical intermediates,phenylpropionic acid compounds,are successfully obtained by catalyzing the reaction of carbon dioxide with phenyl halides using MOF-5,a typical metal-organic framework(MOF)material.The influence of temperature,pressure,catalyst type and light on the reaction is investigated,and a 90.3%selectivity towards fluorophenylpropionic acid is reached.Significantly,the catalysts are effective for varied benzyl compounds containing different substituent groups.The catalysts are stable and remain active after three cycles.     

Antiproliferation- and Apoptosis-Inducible Effects of a Novel Nitrated [6,6,6]Tricycle Derivative (SK2) on Oral Cancer Cells

The benzo-fused dioxabicyclo[3.3.1]nonane core is the central framework in several natural products. Using this core, we had developed a novel nitrated [6,6,6]tricycle-derived compound containing an n-butyloxy group, namely, SK2. The anticancer potential of SK2 was not assessed. This study aimed to determine the antiproliferative function and investigated possible mechanisms of SK2 acting on oral cancer cells. SK2 preferentially killed oral cancer cells but caused no harmful effect on non-malignant oral cells. After the SK2 exposure of oral cancer cells, cells in the sub-G1 phase accumulated. This apoptosis-like outcome of SK2 treatment was validated to be apoptosis via observing an increasing annexin V population. Mechanistically, apoptosis signalers such as pancaspase, caspases 8, caspase 9, and caspase 3 were activated by SK2 in oral cancer cells. SK2 induced oxidative-stress-associated changes. Furthermore, SK2 caused DNA damage (γH2AX and 8-hydroxy-2′-deoxyguanosine). In conclusion, a novel nitrated [6,6,6]tricycle-derived compound, SK2, exhibits a preferential antiproliferative effect on oral cancer cells, accompanied by apoptosis, oxidative stress, and DNA damage.     

Indole-Based Tubulin Inhibitors: Binding Modes and SARs Investigations

Tubulin inhibitors can interfere with normal cell mitosis and inhibit cell proliferation through interfering with the normal structure and function of microtubules, forming spindle filaments. Indole, as a privileged pharmacological skeleton, has been widely used in anti-cancer inhibitors. A variety of alkaloids containing an indole core obtained from natural sources have been proven to inhibit tubulin polymerization, and an ever-increasing number of synthetic indole-based tubulin inhibitors have been reported. Among these, several kinds of indole-based derivatives, such as TMP analogues, aroylindoles, arylthioindoles, fused indole, carbazoles, azacarbolines, alkaloid nortopsentin analogues and bis-indole derivatives, have shown good inhibition activities towards tubulin polymerization. The binding modes and SARs investigations of synthetic indole derivatives, along with a brief mechanism on their anti-tubulin activity, are presented in this review.     

高效液相色谱法测定忍冬藤和叶中8种活性成分

建立了多波长分析忍冬藤和叶中化学成分含量的高效液相色谱分析方法,色谱柱为Aglient Zorbax80A,Extend-C18(4.6mm×250mm,5μm);流动相为0.3%甲酸-乙腈,梯度洗脱;流速为1.5mL/min;检测波长为240、330、360nm;柱温38℃。各指标成分的检出限均低于0.29mg/L;精密度RSD均低于2.29%;标准加入的回收率为91.2%～103.6%。应用新建立的方法测定了7个不同产地忍冬藤和叶中8种活性成分的含量。该方法简单、快速、准确,可用于忍冬藤和叶的质量控制。     

高效阴离子交换色谱分离-脉冲安培检测法测定烟草料液中的糖、糖醇和醇类化合物

建立了高效阴离子交换色谱分离-脉冲安培检测法测定烟草料液中的糖、糖醇以及醇类化合物的方法。以NaOH为淋洗液,在CarboPac MA1阴离子交换柱上等度分离了肌醇、甘油、丙二醇、半乳糖醇、木糖醇、山梨醇、甘露醇、葡萄糖、果糖、蔗糖、甘露糖和半乳糖等12种化合物。对影响分离和检测的条件进行了优化,并在此优化条件下分析了烟草料液中的糖、糖醇以及醇类化合物。12种化合物的检出限为2.0~216μg/L(25.0μL进样,以3倍信噪比计算检出限)。12种化合物浓度为1~5mg/L的标准溶液连续7次进样的RSD为0.7%~4.3%。方法对烟草料液中12种化合物的加标回收率为80%~108%。方法灵敏、高效、简便、快捷。