全文获取类型
收费全文 | 540篇 |
免费 | 26篇 |
专业分类
化学 | 465篇 |
晶体学 | 3篇 |
力学 | 2篇 |
数学 | 36篇 |
物理学 | 60篇 |
出版年
2023年 | 7篇 |
2022年 | 21篇 |
2021年 | 23篇 |
2020年 | 13篇 |
2019年 | 20篇 |
2018年 | 8篇 |
2017年 | 11篇 |
2016年 | 36篇 |
2015年 | 24篇 |
2014年 | 22篇 |
2013年 | 46篇 |
2012年 | 27篇 |
2011年 | 33篇 |
2010年 | 24篇 |
2009年 | 25篇 |
2008年 | 45篇 |
2007年 | 28篇 |
2006年 | 30篇 |
2005年 | 22篇 |
2004年 | 18篇 |
2003年 | 14篇 |
2002年 | 15篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1977年 | 1篇 |
1973年 | 1篇 |
1934年 | 1篇 |
排序方式: 共有566条查询结果,搜索用时 15 毫秒
551.
Korkut A??kal?n 《Journal of Thermal Analysis and Calorimetry》2012,109(1):227-235
Pyrolytic characteristics and kinetics of pistachio shell were studied using a thermogravimetric analyzer in 50?C800?°C temperature range under nitrogen atmosphere at 2, 10, and 15?°C?min?1 heating rates. Pyrolysis process was accomplished at four distinct stages which can mainly be attributed to removal of water, decomposition of hemicellulose, decomposition of cellulose, and decomposition of lignin, respectively. The activation energies, pre-exponential factors, and reaction orders of active pyrolysis stages were calculated by Arrhenius, Coats?CRedfern, and Horowitz?CMetzger model-fitting methods, while activation energies were additionaly determined by Flynn?CWall?COzawa model-free method. Average activation energies of the second and third stages calculated from model-fitting methods were in the range of 121?C187 and 320?C353?kJ?mol?1, respectively. The FWO method yielded a compatible result (153?kJ?mol?1) for the second stage but a lower result (187?kJ?mol?1) for the third stage. The existence of kinetic compensation effect was evident. 相似文献
552.
The stereoselective synthesis of (1R,2R)- and (1S,2S)-trans-2-(diphenylmethylideneamino)cyclopropanecarboxylic acid has been accomplished in six steps starting from (2S)- and (2R)-β-benzyl N-(tert-butoxycarbonyl)aspartate, respectively. The key-step in the reaction sequence is a stereoselective base-induced ring closure with a good trans diastereoselectivity. These novel trans-β-ACC derivatives could be incorporated in dipeptides employing a standard peptide coupling technique. 相似文献
553.
Xanthones with amino substituents were synthesized to diminish the photoreactivity of the xanthone chromophore with DNA, with the objective of using these molecules to study their binding dynamics with DNA. The aminoxanthones showed a strong solvatochromic effect on their singlet and triplet excited-state photophysics, where polar solvents led to a decrease of the energies for the excited states. Quenching of the triplet excited states by nitrite anions was used to determine the binding dynamics, and a residence time in the microsecond time domain was estimated for the bound 2-aminoxanthone with DNA. The quenching experiments performed showed that this methodology will not be applicable to study the binding dynamics of a wide variety of guests with DNA. 相似文献
554.
Baron R Lioubashevski O Katz E Niazov T Willner I 《Organic & biomolecular chemistry》2006,4(6):989-991
The coupled activation of two enzymes: glucose dehydrogenase (GDH) and horseradish peroxidase (HRP), is used to construct the parallel-operating AND and InhibAND logic gates. The added substrates for the respective enzymes, glucose and H(2)O(2), act as the gate inputs, while the biocatalytically generated NADH and gluconic acid provide the output signals that follow the operations of the gates. The two gates are generated in the same vial, thus allowing the logic operations to take place in parallel, and the simultaneous readout of the functions of the gates. 相似文献
555.
Ramesh C Bryant B Nayak T Revankar CM Anderson T Carlson KE Katzenellenbogen JA Sklar LA Norenberg JP Prossnitz ER Arterburn JB 《Journal of the American Chemical Society》2006,128(45):14476-14477
We describe a new structural class of neutral tridentate pyridin-2-yl hydrazine chelates for labeling with tricarbonyl Re/99mTc(I) under aqueous conditions and investigate the receptor binding of synthetic estradiol derivatives with the novel G-protein-coupled receptor GPR30 and estrogen receptors ERalpha/beta. The steroid linkage affected the affinity and selectivity of estrogen binding with these receptors. Fluorescence assays based on calcium signaling demonstrate that membrane-permeable chelates 2 and 3 interact with the receptors in whole cells. These results suggest that in vitro assays will facilitate the development of targeted imaging agents for intracellular receptors and the feasibility of targeting GPR30 and ERalpha/beta for diagnostic tumor imaging. 相似文献
556.
Tamara Lazarević Pašti Tatjana Momić Antonije Onjia Ljubodrag Vujisić Vesna Vasić 《Mikrochimica acta》2010,170(3-4):289-297
In order to improve the sensitivity of assays for inhibitors of the enzyme acetylcholine esterase (AChE), an effective method was developed for the conversion of the organophosphate pesticides (OPs) diazinon, malathion, chlorpyrifos, azinphos-methyl and phorate into more toxic inhibitors. This was accomplished by converting them from the thio form into their oxo form using the enzyme myeloperoxidase. The oxo forms, which are the only products of conversion, were determined by AChE bioassays, using either the free enzyme, or a flow injection analysis manifold with immobilized AChE and spectrophotometric detection. All modified OPs exhibited inhibitory power at ppb levels and within 10 min. The method is considered to represent an excellent means for improving the sensitivity of assays for determination of OPs. 相似文献
557.
The axisymmetric time-fractional diffusion equation with mass absorption is studied in a circle under the time-harmonic Dirichlet boundary condition. The Caputo derivative of the order is used. The investigated equation can be considered as the time-fractional generalization of the bioheat equation and the Klein–Gordon equation. Different formulations of the problem for integer values of the time-derivatives and are also discussed. The integral transform technique is employed. The outcomes of numerical calculations are illustrated graphically for different values of the parameters. 相似文献
558.
Tamara Carevi Marina Kosti Biljana Nikoli Dejan Stojkovi Marina Sokovi Marija Ivanov 《Molecules (Basel, Switzerland)》2022,27(20)
Hesperetin is the aglycone of citrus flavonoid hesperidin. Due to the limited information regarding hesperetin antimicrobial potential and emerging need for novel antimicrobials, we have studied its antimicrobial activity (microdilution assay), antibiofilm activity with different assays in two models (mono- and polymicrobial biofilm), and toxicity (MTT and brine shrimp lethality assays). Hesperetin inhibited growth of all Candida isolates (minimal inhibitory concentration, MIC, 0.165 mg/mL), while it’s inhibitory potential towards Staphylococcus aureus was lower (MIC 4 mg/mL). Hesperetin (0.165 mg/mL) reduced ability of Candida to form biofilms and moderately reduced exopolysaccharide levels in biofilm matrix. Effect on the eradication of 24 h old C. albicans biofilms was promising at 1.320 mg/mL. Inhibition of staphylococcal biofilm formation required higher concentrations of hesperetin (<50% inhibition with MIC 4 mg/mL). Establishment of polymicrobial C. albicans-S. aureus biofilm was significantly inhibited with the lowest examined hesperetin concentration (1 mg/mL) in crystal violet and CFU assays. Hesperetin toxicity was examined towards MRC-5 fibroblasts (IC50 0.340 mg/mL) and in brine shrimp lethality assay (LC50 > 1 mg/mL). Hesperetin is efficient in combating growth and biofilm formation of Candida species. However, its antibacterial application should be further examined due to the cytotoxic effects provoked in the antibacterial concentrations. 相似文献
559.
Balázs Pogrányi Dr. Tamara Mielke Dr. Alba Díaz-Rodríguez Dr. Jared Cartwright Dr. William P. Unsworth Prof. Gideon Grogan 《Angewandte Chemie (International ed. in English)》2023,62(5):e202214759
A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO-PaDa-I-H) is a highly effective catalyst for the oxygenation of a diverse range of N-heterocyclic compounds. Scalable biocatalytic oxygenations (27 preparative examples, ca. 100 mg scale) have been developed across a wide range of substrates, including alkyl pyridines, bicyclic N-heterocycles and indoles. H2O2 is the only stoichiometric oxidant needed, without auxiliary electron transport proteins, which is key to the practicality of the method. Reaction outcomes can be altered depending on whether hydrogen peroxide was delivered by syringe pump or through in situ generation using an alcohol oxidase from Pichia pastoris (PpAOX) and methanol as a co-substrate. Good synthetic yields (up to 84 %), regioselectivity and enantioselectivity (up to 99 % ee) were observed in some cases, highlighting the promise of UPOs as practical, versatile and scalable oxygenation biocatalysts. 相似文献
560.
For the selection of the polymer materials and polymer blends for various fields of applications the stability of material under constant deformation and constant load are very important. In this paper, the copolymers high-impact polystyrene, PS-HI, styrene-ethylene/buthylene-styrene block copolymer, SEBS, and their blends PS-HI/SEBS were investigated. The investigations were done by DMA analysis. The secondary viscoelastic functions, creep, creep modulus, stress and flexural relaxation modulus were investigated in creep and stress relaxation experiment at temperatures 25, 35, 45, 55 and 65°C during 1 h. The master curves were created by time-temperature correspondence principle, TTC. The correlation of the secondary viscoelastic functions with time, temperature and content of the hard, PS, phase was discussed. 相似文献