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261.
Momoko Ishida Rika Ohara Fuka Miyagawa Hiroe Kikuzaki Kosuke Nishi Hiroyuki Onda Nanami Yoshino Takuya Sugahara 《Molecules (Basel, Switzerland)》2022,27(13)
Cuminum cyminum L. (cumin) is an annual plant of the Umbelliferae family native to Egypt. We previously showed that the aqueous extract of cumin seeds suppresses degranulation by downregulating the activation of antigen-induced intracellular signaling molecules in rat basophilic leukemia RBL-2H3 cells. However, the active substances in the extract have not yet been identified. Accordingly, herein, we aimed to ascertain the water-soluble substances present in cumin seeds that inhibit degranulation, which led to the identification of umbelliferose, a characteristic trisaccharide present in plants of the Umbelliferae family. Our study is the first to reveal the degranulation-suppressing activity of umbelliferose, and quantification studies suggest that cumin seed powder contains 1.6% umbelliferose. Raffinose, an isomer of umbelliferose, was also found to significantly suppress antigen-induced degranulation, but less so than umbelliferose. Both umbelliferose and raffinose contain sucrose subunits in their structures, with galactose moieties bound at different sites. These differences in structure suggest that the binding of galactose to the sucrose subunit at the α1-2 bond contributes to its strong degranulation-inhibiting properties. 相似文献
262.
Mostafa Abdelrahman Sho Hirata Takuya Mukae Tomohiro Yamada Yuji Sawada Magdi El-Syaed Yutaka Yamada Muneo Sato Masami Yokota Hirai Masayoshi Shigyo 《Molecules (Basel, Switzerland)》2021,26(5)
Garlic (Allium sativum) is the second most important Allium crop that has been used as a vegetable and condiment from ancient times due to its characteristic flavor and taste. Although garlic is a sterile plant that reproduces vegetatively through cloves, garlic shows high biodiversity, as well as phenotypic plasticity and environmental adaptation capacity. To determine the possible mechanism underlying this phenomenon and to provide new genetic materials for the development of a novel garlic cultivar with useful agronomic traits, the metabolic profiles in the leaf tissue of 30 garlic accessions collected from different geographical regions, with a special focus on the Asian region, were investigated using LC/MS. In addition, the total saponin and fructan contents in the roots and cloves of the investigated garlic accessions were also evaluated. Total saponin and fructan contents did not separate the garlic accessions based on their geographical origin, implying that saponin and fructan contents were clone-specific and agroclimatic changes have affected the quantitative and qualitative levels of saponins in garlic over a long history of cultivation. Principal component analysis (PCA) and dendrogram clustering of the LC/MS-based metabolite profiling showed two major clusters. Specifically, many Japanese and Central Asia accessions were grouped in cluster I and showed high accumulations of flavonol glucosides, alliin, and methiin. On the other hand, garlic accessions grouped in cluster II exhibited a high accumulation of anthocyanin glucosides and amino acids. Although most of the accessions were not separated based on country of origin, the Central Asia accessions were clustered in one group, implying that these accessions exhibited distinct metabolic profiles. The present study provides useful information that can be used for germplasm selection and the development of new garlic varieties with beneficial biotic and abiotic stress-adaptive traits. 相似文献
263.
Prof. Shingo Saito Toshiki Sakamoto Naoki Tanaka Ryo Watanabe Takuya Kamimura Kazuki Ota Kathryn R. Riley Keitaro Yoshimoto Yuiko Tasaki-Handa Masami Shibukawa 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(39):10058-10067
In DNA aptamer selection, existing methods do not discriminate aptamer sequences based on their binding affinity and function and the reproducibility of the selection is often poor, even for the selection of well-known aptamers like those that bind the commonly used model protein thrombin. In the present study, a novel single-round selection method (SR-CE selection) was developed by combining capillary electrophoresis (CE) with next generation sequencing. Using SR-CE selection, a successful semi-quantitative and semi-comprehensive aptamer selection for thrombin was demonstrated with high reproducibility for the first time. Selection rules based on dissociation equilibria and kinetics were devised to obtain families of analogous sequences. Selected sequences of the same family were shown to bind thrombin with high affinity. Furthermore, data acquired from SR-CE selection was mined by creating sub-libraries that were categorized by the functionality of the aptamers (e. g., pre-organized aptamers versus structure-induced aptamers). Using this approach, a novel fluorescent molecular recognition sensor for thrombin with nanomolar detection limits was discovered. Thus, in this proof-of-concept report, we have demonstrated the potential of a “DNA Aptaomics” approach to systematically design functional aptamers as well as to obtain high affinity aptamers. 相似文献
264.
Haruyasu Asahara Takuya Koizumi Eiko Mochizuki Takumi Oshima 《Acta Crystallographica. Section C, Structural Chemistry》2006,62(3):o136-o138
The crystal structures of the two thermally equilibrated conformational isomers of the epoxide 1′,5′‐dimethylspiro[10,11‐dihydro‐5H‐dibenzo[a,d]cycloheptene‐5,8′‐4′‐oxatricyclo[5.1.0.03,5]octane]‐2′,6′‐dione, C23H20O3, have been determined by X‐ray diffraction. In the tricyclic dione skeleton, the oxirane and cyclopropane rings adopt an anti structure with respect to the conjunct quinone frame. The spiro‐linked 10,11‐dihydro‐5H‐dibenzo[a,d]cycloheptene ring of the major isomer has a fairly twisted boat form, folding opposite to the adjoining cyclopropane methyl substituent, whereas the seven‐membered ring of the minor isomer has an almost ideal twist–boat form, inversely folding to the side of the relevant methyl group. The conformational structures of these isomers have been compared with those of the corresponding isomers of the unepoxidized homobenzoquinone. 相似文献
265.
Hidetoshi Sekiguchi Atsushi Kanzawa Takuya Honda 《Plasma Chemistry and Plasma Processing》1989,9(2):257-275
Effects of the thermal quenching process in the synthesis of NO and the decomposition of CO2 were studied using a thermal argon plasma and different-i.d. cooling tubes. Four tubes of different i.d.'s were used to change the cooling rate. The conversions obtained in both reactions increased with decreasing quenching tube diameter. Furthermore, the concept of quenching temperature was introduced. This temperature was obtained from two time constants of reaction and cooling rate. The conversions into CO can be estimated in a similar manner to the NO synthesis with a proper modification for radicals which remain at high concentrations at the quenching temperature. 相似文献
266.
Takuya Hara 《Integral Equations and Operator Theory》1992,15(4):551-567
Let
be a Hilbert space. A continuous positive operatorT on
uniquely determines a Hilbert space
which is continuously imbedded in
and for which
with the canonical imbedding
. A Kreîn space version of this result, however, is not valid in general. This paper provides a necessary and sufficient condition for that a continuous selfadjoint operatorT uniquely determines a Kreîn space (
) which is continuously imbedded in
and for which
with the canonical imbedding
. 相似文献
267.
Takuya Sato Nobuyuki Hara Nobuo Tajima Atsushi Sudo Michiya Fujiki Yoshitane Imai 《Tetrahedron letters》2018,59(17):1619-1622
Although chiral 1,1′-binaphthalene-2,2′-diyl-O,O-bis(N,N-dimethylthiocarbamate) (1) revealed no circularly polarized luminescence (CPL) signals, Newman–Kwart rearrangement of O-thiocarbamate groups at 1 yielded clear CPL signals from 1,1′-binaphthalene-2,2′-diyl-S,S-bis(N,N-dimethylthiocarbamate) (2), which acts as a CPL-gen molecule. 相似文献
268.
Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Reactions of Aldehyde Acyl Anions with either Diarylmethyl or Allylic Carbonates
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Dr. Shigeo Yasuda Takuya Ishii Shunsuke Takemoto Hiroki Haruki Prof. Dr. Hirohisa Ohmiya 《Angewandte Chemie (International ed. in English)》2018,57(11):2938-2942
Benzylation and allylation of aldehyde acyl anions were enabled by the merger of a thiazolium N‐heterocyclic carbene (NHC) catalyst and a palladium/bisphosphine catalyst in a synergistic manner. Owing to the mildness of the reaction conditions, various functional groups were tolerated in the substrates. 相似文献
269.
Iron‐Catalyzed Aminative Cyclization/Intermolecular Homolytic Aromatic Substitution Using Oxime Esters and Simple Arenes
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Intermolecular C?H alkylation of simple arenes in the presence of an iron catalyst has been achieved in a cascade manner with an aminative cyclization triggered by N?O bond cleavage of an alkene‐tethered oxime ester. Various arenes, including electron‐rich and electron‐poor arenes, and heteroarenes can be employed in the reaction system. Regioselectivity and radical trapping experiments support the involvement of alkyl radical species, which undergo a homolytic aromatic substitution (HAS) to afford the arylation products. 相似文献
270.
Shindou Takuya Katayama Shingo Yamada Noriko Kamiya Kanichi 《Journal of Sol-Gel Science and Technology》2003,27(1):15-21
Polydimethylsiloxane (PDMS)-based inorganic/organic hybrids films were prepared on polyimide sheets by the sol-gel method using silanol-terminated PDMS and titanium tetraisopropoxide as starting materials. The effect of heat-treatment temperature on the surface property of the hybrid films was examined in terms of contact angle of water and Tapping-Mode Atomic Force Microscopy (AFM). AFM phase images showed the presence of domains, 200–500 nm in size, on the surface of these films after heat-treatment below 300°C. These regions were more hydrophilic than the rest of the area. The domains disappeared at 300°C and the surface became homogeneous surface of the peak to valley value, about 10 nm. It is also uniformly hydrophobic and a maximum contact angle (about 115°C) was obtained. 相似文献