全文获取类型
收费全文 | 3544篇 |
免费 | 133篇 |
国内免费 | 14篇 |
专业分类
化学 | 3029篇 |
晶体学 | 24篇 |
力学 | 23篇 |
数学 | 191篇 |
物理学 | 424篇 |
出版年
2023年 | 15篇 |
2022年 | 24篇 |
2021年 | 36篇 |
2020年 | 38篇 |
2019年 | 47篇 |
2018年 | 30篇 |
2017年 | 38篇 |
2016年 | 68篇 |
2015年 | 71篇 |
2014年 | 83篇 |
2013年 | 186篇 |
2012年 | 188篇 |
2011年 | 233篇 |
2010年 | 129篇 |
2009年 | 142篇 |
2008年 | 239篇 |
2007年 | 250篇 |
2006年 | 213篇 |
2005年 | 214篇 |
2004年 | 160篇 |
2003年 | 154篇 |
2002年 | 120篇 |
2001年 | 60篇 |
2000年 | 80篇 |
1999年 | 53篇 |
1998年 | 52篇 |
1997年 | 60篇 |
1996年 | 52篇 |
1995年 | 34篇 |
1994年 | 32篇 |
1993年 | 43篇 |
1992年 | 26篇 |
1991年 | 24篇 |
1990年 | 27篇 |
1989年 | 24篇 |
1988年 | 25篇 |
1987年 | 24篇 |
1986年 | 12篇 |
1985年 | 52篇 |
1984年 | 40篇 |
1983年 | 14篇 |
1982年 | 25篇 |
1981年 | 33篇 |
1980年 | 31篇 |
1979年 | 41篇 |
1978年 | 26篇 |
1977年 | 24篇 |
1976年 | 22篇 |
1975年 | 19篇 |
1974年 | 25篇 |
排序方式: 共有3691条查询结果,搜索用时 273 毫秒
991.
Kamata J Okada T Kotake Y Niijima J Nakamura K Uenaka T Yamaguchi A Tsukahara K Nagasu T Koyanagi N Kitoh K Yoshimatsu K Yoshino H Sugumi H 《Chemical & pharmaceutical bulletin》2004,52(9):1071-1081
As part of a series of studies to discover new topoisomerase II inhibitors, novel pyrimidoacridones, pyrimidophenoxadines, and pyrimidocarbazoles were synthesized, and in vitro and in vivo antitumor activities and DNA-protein and/or DNA-topoisomerase II cross-linking activity as an indicator of topoisomerase II-DNA cleavable complex formation were evaluated. The pyrimidocarbazoles possessed high in vitro and in vivo potencies. Compound 26 (ER-37326), 8-acetyl-2-[2-(dimethylamino)ethyl]-1H-pyrimido[5,6,1-jk]carbazole-1,3(2H)-dione, showed in vitro growth inhibitory activity with respective IC(50) values of 0.049 microM and 0.35 microM against mouse leukemia P388 and human oral cancer KB. In vivo, this compound inhibited the tumor growth of mouse sarcoma M5076 implanted into mice with T/C values of 42% and 13% at 3.13 and 6.25 mg/kg/d respectively without significantly affecting the body weight. In addition, compound 26 (ER-37326) increased the formation of DNA-topoisomerase II cross-linking in P388 cells. 相似文献
992.
Enrico Traversa Maria Luisa Di Vona Patrizia Nunziante Silvia Licoccia Takeshi Sasaki Naoto Koshizaki 《Journal of Sol-Gel Science and Technology》2000,19(1-3):733-736
Ag-TiO2 thin films were prepared with a sol-gel route, using titanium isopropoxide and silver nitrate as precursors, at 0.03 and 0.06 Ag/Ti nominal atomic ratios. After drying at 80°C, the films were fired at 300°C and 500°C for 30 min. The films were analysed by X-ray diffraction (XRD) with glancing angle, and X-ray photoelectron spectroscopy (XPS), with depth profiling of the concentration. XPS analysis showed the presence of C and N as impurities in the nanocomposite films. Their concentration decreased with increasing the firing temperature. Chemical state analysis showed that Ag was present in metallic state, except for the very outer layer where it was present as Ag+. For the films prepared with a Ag/Ti concentration of 0.06, depth profiling measurements of the film fired at 300°C showed a strong Ag enrichment at the outer surface, while composition remained almost constant within the rest of the film, at 0.019. For the films heated to 500°C, two layers were found, where the Ag/Ti ratios were 0.015 near the surface and 0.026 near the substrate. 相似文献
993.
Mitsutoshi Yanagiya Kimiyoshi Kaneko Takashi Kaji Takeshi Matsumoto 《Tetrahedron letters》1979,20(20):1761-1764
Photocycloadducts from dl-piperitone and 1,1-dimethoxyethylene afforded bicyclo[3.2.1]oct-6-en-8-one derivatives under glc conditions in excellent yields. The synthesis of the title sesquiterpenes was accomplished using the bridged bicyclic compounds as intermediates. 相似文献
994.
Takeshi Wada Terutaka Watanabe Masaaki Takehisa Sueo Machi 《Journal of polymer science. Part A, Polymer chemistry》1974,12(8):1585-1608
The effects of temperature on the radiation-induced polymerization of ethylene in bulk and in the presence of ethyl alcohol, n-butyl alcohol, tert-butyl alcohol, cyclohexane, 2,2,4-trimethylpentane, and 2,2,5-trimethylhexane were studied. The changes of the amounts of polymerized monomer with the reaction temperature were different from each other in these reaction systems, especially in the range lower than 60–80°C. At temperatures lower than 60–80°C, as the reaction temperature increases, the amount of polymerized monomer decreased in bulk and in the presence of tert-butyl alcohol. The amount was almost constant in the presence of ethyl alcohol and 2,2,4-trimethylpentane, and it increased in the presence of n-butyl alcohol, cyclohexane, and 2,2,5-trimethylhexane. However, in the temperature range higher than 60–80°C, the amount of polymerized monomer increased with increasing temperature in every reaction system except for bulk polymerization. The molecular weight of polymer decreased with increasing temperature in every reaction system except at temperatures lower than 25°C. The molecular weight of polymer formed in bulk, in tert-butyl alcohol, and also in 2,2,4-trimethylpentane were relatively higher than that in other reaction systems. A bimodal molecular weight distribution was observed for the polymer formed in bulk and in tert-butyl alcohol at 40–60°C. These results are discussed in connection with the heterogeneity of the reaction system. The differences due to temperature in each reaction system are explained as due to the difference in affinity of the reaction system for the propagating chain and in the facility of chain transfer to the medium. 相似文献
995.
Masanori Taguchi Ikuyoshi Tomita Yasuhiko Yoshida Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》1999,37(21):3916-3921
The block copolymerization of allene derivatives (3A–3D) with 1,3-butadiene (2) by [(allyl)NiOCOCF3]2 (1) is described. For instance, the living coordination polymerization of phenylallene (3A, 50 equiv) starting from the living poly(2), which was prepared by the polymerization of 2 (160 equiv) by 1, successfully gave a block copolymer of 2 and 3A in high yield. The molecular weight of the block copolymer (4A) in gel permeation chromatography shifted clearly to the higher molecular weight region and kept a unimodal distribution (Mn = 17,400, Mw/Mn = 1.23) in comparison with that of the starting living poly(2) (Mn = 5,600, Mw/Mn = 1.67). The ratio of each segment and the molecular weight of the resulting copolymers could be controlled by the feed ratio of each monomer. The block copolymerization also proceeded successfully by the inverse order of the monomer feeding (i.e., the polymerization of 3A followed by that of 2) to obtain the corresponding block copolymers in high yields. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 3916–3921, 1999 相似文献
996.
Jong-Chan Lee Ikuyoshi Tomita Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》1999,37(13):1979-1986
The synthesis of pyridine-containing polymers was carried out by the cycloaddition of diynes with nitriles in the presence of organocobalt complexes as catalysts. As a model experiment, the pyridine-formation reaction of monofunctional acetylenes with nitriles was reexamined in detail in the presence of organocobalt catalysts, from which the combination of terminal aliphatic acetylenes and aromatic nitriles was proved to be suitable for the specific pyridine-formation process. On the basis of this result, the polymerization of terminal aliphatic diynes with aromatic nitriles was carried out in the presence of the cobalt catalyst (10 mol %) to give polymers containing substituted pyridine moieties in the main chain in high yields. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1979–1986, 1999 相似文献
997.
998.
Emiko Koyama Fumio Sanda Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》1997,35(2):345-352
Syntheses and polycondensations of optically active hydroxycarboxylic acids prepared from acid anhydrides and aminoalcohols were carried out. Novel polymers with M̄n 9900–27,200 were obtained by the polycondensations of hydroxycaboxylic acids derived from maleic or succinic acid using 1.2 eq. of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC · HCl) in DMF (2M) at room temperature for 8 h in satisfactory yields. Meanwhile, a hydroxycarboxylic acid obtained from phthalic acid afforded no polymer but a phthalimide derivative. The radical additions of ethanethiol or mercaptoethanol with the polymers derived from maleic anhydride proceeded smoothly in satisfactory incorporation ratios (65–98%), respectively. The polymer obtained from succinic anhydride and 2-aminoethanol showed hydrolytic degradability. © 1997 John Wiley & Sons, Inc. 相似文献
999.
Fumio Sanda Toru Abe Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》1997,35(13):2619-2629
Syntheses and radical polymerizations of several (meth)acrylamides having L -amino acid moieties were examined. The monomers were prepared by the reactions of L -amino acid ester hydrochlorides with (meth)acryloyl chloride in the presence of triethylamine in satisfactory yields. Radical polymerizations of the monomers were carried out in the presence of AIBN (1 mol %) in bulk and in several solvents to afford the corresponding polymers in satisfactory yield. The glass transition temperatures and specific rotations of the polymers depended on the substituents of the L -amino acid moieties. Nearly the same specific rotations were observed for the monomers and the model compounds of the polymer units, N-pivaloyl amino acid methyl esters. On the contrary, the specific rotations of the polymers shifted to the negative direction in ca. 30°. The interaction between the polymer side chains might affect the changes in the specific rotations from monomers to polymers. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 2619–2629, 1997 相似文献
1000.
Osamu Shimomura Toshihiko Sato Ikuyoshi Tomita Masato Suzuki Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》1997,35(14):2813-2819
A monomer having dibenzothiophene moiety, 2-vinyldibenzothiophene (1), was prepared by the Ni-catalyzed cross-coupling reaction of vinyl bromide with the Grignard reagent of 2-bromodibenzothiophene. The radical homopolymerization of 1 and the copolymerization with styrene were carried out at 60°C in toluene (1.0M) for 20 h using AIBN (5 mol %) as an initiator to obtain the corresponding polymers in high yields. Thermal analyses of the copolymers showed that both 10% weight loss and glass transition temperatures increase when increasing the content of 1 unit. The monomer reactivity ratio was evaluated as r1 = 2.55 (1) and r2 = 0.16 (styrene). © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35 : 2813–2819, 1997 相似文献