全文获取类型
收费全文 | 1690篇 |
免费 | 59篇 |
国内免费 | 12篇 |
专业分类
化学 | 1368篇 |
晶体学 | 23篇 |
力学 | 23篇 |
数学 | 128篇 |
物理学 | 219篇 |
出版年
2023年 | 10篇 |
2022年 | 16篇 |
2021年 | 20篇 |
2020年 | 24篇 |
2019年 | 34篇 |
2018年 | 25篇 |
2017年 | 16篇 |
2016年 | 48篇 |
2015年 | 33篇 |
2014年 | 44篇 |
2013年 | 124篇 |
2012年 | 98篇 |
2011年 | 114篇 |
2010年 | 79篇 |
2009年 | 60篇 |
2008年 | 109篇 |
2007年 | 91篇 |
2006年 | 90篇 |
2005年 | 88篇 |
2004年 | 80篇 |
2003年 | 75篇 |
2002年 | 58篇 |
2001年 | 20篇 |
2000年 | 17篇 |
1999年 | 22篇 |
1998年 | 16篇 |
1997年 | 25篇 |
1996年 | 12篇 |
1995年 | 12篇 |
1994年 | 20篇 |
1993年 | 17篇 |
1992年 | 17篇 |
1991年 | 21篇 |
1990年 | 10篇 |
1989年 | 9篇 |
1986年 | 8篇 |
1985年 | 15篇 |
1984年 | 23篇 |
1983年 | 10篇 |
1982年 | 18篇 |
1981年 | 12篇 |
1980年 | 10篇 |
1979年 | 9篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1976年 | 13篇 |
1974年 | 8篇 |
1973年 | 8篇 |
1970年 | 7篇 |
1969年 | 10篇 |
排序方式: 共有1761条查询结果,搜索用时 15 毫秒
201.
202.
SUPER TOUGH GELS WITH A DOUBLE NETWORK STRUCTURE 总被引:1,自引:0,他引:1
Tasuku Nakajima Takayuki Kurokawa Hidemitsu Furukawa Yoshimi Tanaka Yoshihito Osada 龚剑萍 《高分子科学》2009,27(1)
Living tissues work with fantastic functions in soft and wet gel-like state.Thus,hydrogels have attracted much attention as excellent soft and wet materials,suitable tot making artificial organs for medical treatments.However, conventional hydrogels are mechanically too weak for practical uses.We have created double network (DN) hydrogels with extremely high mechanical strength in order to overcome this problem.DN gels are interpenetrating network (IPN) hydrogels consisting of rigid polyelectrolyte and s... 相似文献
203.
Dr. Yasunori Toda Takayuki Yoshida Kaoru Arisue Prof. Dr. Kazuaki Fukushima Dr. Hiroyoshi Esaki Ayaka Kikuchi Prof. Dr. Hiroyuki Suga 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(41):10578-10582
Chiral Lewis acid-catalyzed asymmetric alcohol addition reactions to cyclic carbonyl ylides generated from N-(α-diazocarbonyl)-2-oxazolidinones featuring a dual catalytic system are reported. Construction of a chiral quaternary heteroatom-substituted carbon center was accomplished in which the unique heterobicycles were obtained in good yields with high stereoselection. The alcohol adducts were successfully converted to optically active oxazolidine-2,4-diones by hydrolysis. Mechanistic studies by DFT calculations revealed that alcohols could be activated by Lewis acids, enabling enantioselective protonation of the carbonyl ylides. 相似文献
204.
Takayuki Miki Keigo Namii Kenta Seko Shota Kakehi Goshi Moro Hisakazu Mihara 《Chemical science》2022,13(43):12634
Phage display is the most widely used technique to discover de novo peptides that bind to target proteins. However, it is associated with some challenges such as compositional bias. In this study, to overcome these difficulties, we devised a ‘pattern enrichment analysis.’ In this method, two samples (one obtained by affinity selection, the other simply amplified without selection) are prepared, and the two sequence datasets read on next-generation sequencer are compared to find the three-residue pattern most enriched in the selected sample. This allows us to compare two sequence datasets with high coverage and facilitates the identification of peptide sequences and the key residues for binding. We also demonstrated that this approach in the combination with structured peptide libraries allowed spatial mapping of the enriched sequence patterns. Here, we prepared a phage library displaying chemically stapled helical peptides with the X1C2X3X4X5X6X7X8C9X10 sequence, where X is any amino acid. To validate our method, we performed screening against the HDM2 protein. The results showed that the hydrophobic residues (Phe, Tyr, Trp and Leu) that are key to interactions with HDM2 were clearly identified by the pattern enrichment analysis. We also performed selection targeting the SARS-CoV-2 spike RBD in the same manner. The results showed that similar patterns were enriched among the hit peptides that inhibited the protein–protein interaction.To effectively identify helical peptide binders from a phage library, we developed “pattern enrichment analysis,” which finds the enriched three-residue patterns by comparison with a control sample. 相似文献
205.
Takayuki Toyoda Hisakazu Mihara Akihiko Ueno 《Macromolecular rapid communications》2002,23(15):905-908
Peptides bearing β‐cyclodextrin and 4‐(N,N‐dimethylamino)benzoyl (DMAB) units in the peptide side chains were prepared as chemosensors for molecule detection. The DMAB unit was expected to be included into the cyclodextrin cavity intramolecularly. However, these peptides exhibited no twisted intramolecular charge transfer fluorescence and the normal fluorescence intensity decreased upon the addition of 1‐adamantanol as an exogenous guest, indicating that the DMAB units are shallowly included in the cyclodextrin cavities. 相似文献
206.
207.
Summary: New main‐chain‐type polymers of 8‐quinolinol were prepared by organometallic polycondensation. They had a poly(aryleneethynylene)‐type structure and exhibited photoluminescence with a peak at about 470 nm and quantum yields of 21–39%. Metal ions such as Zn2+ and Al3+ modified the photoluminescence.
208.
209.
Prof. Dr. Tomoaki Tanase Dr. Kanako Nakamae Haruka Miyano Prof. Dr. Yasuyuki Ura Prof. Dr. Yasutaka Kitagawa Dr. Shiho Yada Prof. Dr. Tomokazu Yoshimura Prof. Dr. Takayuki Nakajima 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(47):12078-12103
A series of the octapalladium chains supported by meso-Ph2PCH2P(Ph)CH2P(Ph)CH2PPh2 (meso-dpmppm) ligands, [Pd8(meso-dpmppm)4(L)2](BF4)4 (L=none ( 1 ), solvents: CH3CN ( 2 a ), dmf ( 2 b ), dmso ( 2 c ), RN≡C: R=Xyl ( 3 a ), Mes ( 3 b ), Dip ( 3 c ), tBu ( 3 d ), Cy ( 3 e ), CH3(CH2)7 ( 3 f ), CH3(CH2)11 ( 3 g ), CH3(CH2)17 ( 3 h )) and [Pd8(meso-dpmppm)4(X)2](BF4)2 (X=Cl ( 4 a ), N3 ( 4 b ), CN ( 4 c ), SCN ( 4 d )), were synthesized by using 2 a as a stable good precursor, and characterized by spectroscopic (IR, 1H and 31P NMR, UV-vis-NIR, ESI-MS) measurements and X-ray crystallographic analyses (for 1 , 2 a , b , 3 a , b , e , f , 4 a – d ). On the basis of DFT calculations on the X-ray determined structure of 2 b ( [2b-Pd8]4+ ) and the optimized models [Pd8(meso-Ph2PCH2P(H)CH2P(H)CH2PH2)4(CH3CN)2]4+ ( [Pd8Ph8]4+ ) and [Pd8(meso-H2PCH2P(H)CH2P(H)CH2PH2)4(CH3CN)2]4+ ( [Pd8H8]4+ ), with and without empirically calculating dispersion force stabilization energy (B3LYP-D3, B3LYP), the formation energy between the two Pd4 fragments is assumed to involve mainly noncovalent interactions (ca. −70 kcal/mol) with four sets of interligand C−H/π interactions and Pd⋅⋅⋅Pd metallophilic one, while electron shared covalent interactions are almost canceled out within the Pd8 chain. All the compounds isolated are stable in solution and exhibit characteristic absorption at ∼900 nm, which is assignable to a spin allowed HOMO to LUMO transition, and shows temperature dependent intensity change with variable absorption coefficients presumably due to coupling with some thermal vibrations. The structures and electronic states of the Pd8 chains are found finely tunable by varying the terminal capping ligands. In particular, theoretical calculations elucidated that the HOMO-LUMO energy gap is systematically related to the central Pd−Pd distance (2.7319(6)–2.7575(6) Å) by two ways with neutral ligands L ( 1 , 2 , 3 ) and with anionic ligands X ( 4 ), which are reflected on the NIR absorption energy of 867–954 nm. The isocyanide terminated Pd8 complexes ( 3 ) further reacted with excess of RNC (6 eq) to afford the Pd4 complexes, [Pd4(meso-dpmppm)2(RNC)2](BF4)2 ( 13 ), and the cyclic voltammograms of 2 a (L=CH3CN), 3 , and 13 (R=Xyl, Mes, tBu, Cy) demonstrated wide range redox behaviors from 2{Pd4}4+ to 2{Pd4}0 through 2{Pd4}2+↔{Pd8}4+, {Pd8}3+, and {Pd8}2+ strings. The oxidized complexes, [Pd4(meso-dpmppm)2(RNC)3](BF4)4 ( 16 ), were characterized by X-ray analyses, and the two-electron reduced chain of [Pd8(meso-dpmppm)4](BF4)2 ( 7 ) was analyzed by spectroscopic and electrochemical techniques and DFT calculations. Reactions of 2 a with 1 equiv. of aromatic linear bisisocyanide (BI) in CH2Cl2 deposited insoluble coordination polymers, {[Pd8(meso-dpmppm)4(BI)](BF4)4}n ( 5 ), and interestingly, they were soluble in acetonitrile, 31P{1H} and 1H DOSY NMR spectra as well as SAXS curves suggesting that the coordination polymers may exist in acetonitrile as dynamically 1D self-assembled coordination polymers comprising ca. 50 units of the Pd8 rod averaged within the timescale. 相似文献
210.
Takayuki Yamanaka Hideki Fukano Ken Tsuzuki Munehisa Tamura Ryuzo Iga Matsuyuki Ogasawara Yasuhiro Kondo Tadashi Saitoh 《光学学报》2003,23(Z1)
A comprehensive analysis of multi-quantum-well electroabsorption modulators buried with semi-insulating (SI)-InP is presented. We quantitatively demonstrate that suppression of Zn diffusion into the burying and optical core layers plays a key role in high-speed and high-extinction operation. 相似文献