全文获取类型
收费全文 | 238篇 |
免费 | 8篇 |
专业分类
化学 | 191篇 |
晶体学 | 7篇 |
力学 | 6篇 |
数学 | 10篇 |
物理学 | 32篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 7篇 |
2018年 | 3篇 |
2017年 | 1篇 |
2016年 | 5篇 |
2015年 | 8篇 |
2014年 | 5篇 |
2013年 | 10篇 |
2012年 | 3篇 |
2011年 | 17篇 |
2010年 | 8篇 |
2009年 | 9篇 |
2008年 | 11篇 |
2007年 | 13篇 |
2006年 | 19篇 |
2005年 | 15篇 |
2004年 | 20篇 |
2003年 | 11篇 |
2002年 | 7篇 |
2001年 | 1篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1970年 | 2篇 |
1968年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有246条查询结果,搜索用时 31 毫秒
61.
Kawai T Shibata A Kurosawa K Sato Y Kato S Ohki K Hashimoto T Sakura N 《Chemical & pharmaceutical bulletin》2006,54(5):659-664
Porcine neuromedin U-8 (X-Asn-NH(2), X=H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg) is occasionally unstable in the biological fluids used for bioassay as well as in the acidic solutions used for purification of synthetic peptides. In this study, HPLC examination of an incubate solution of X-Asn-NH(2) revealed that the main decomposition products in Tyrode's solution (pH 7.4) were either alpha- or beta-monocarboxylic acid analogs (X-Asn-OH or X-Asp-NH(2)), and that no dicarboxylic acid analog (X-Asp-OH) was produced. Further investigation, employing a model peptide (Y-Asn-NH(2), Y=Benzoyl-Pro-Arg) incubated in a 0.1 M sodium bicarbonate solution at 60 degrees C, revealed that the decomposition of C-terminal Asn-NH(2) occurred through the formation of an aminosuccinimide intermediate (Y-Asu), at a rate faster than that of Y-Asn-Ser peptide but slower than that of Y-Asn-Gly peptide. Mild acid hydrolysis of X-Asn-NH(2) examined in a 1 M HCl solution at 60 degrees C yielded X-Asn-OH and X-Asp-NH(2), which further decomposed to yield X-Asp-OH. The C-terminal degradation of X-Asn-NH(2) resulted in reduced biological and immunochemical binding activities. 相似文献
62.
63.
The surface tension of aqueous solutions of a sodium chloride (NaCl)-decyl methyl sulfoxide (DeMS) mixture was measured as a function of the total molality of the mixture and the mole fraction of DeMS in the mixture at 298.15 K under atmospheric pressure. The total surface density of the mixture and the mole fraction of DeMS in the adsorbed film and micelle were numerically evaluated by applying the thermodynamic treatment of surfactant mixture to the NaCl-DeMS mixture. Miscibility of NaCl and DeMS in the adsorbed film and micelle was clarified by use of the phase diagram of adsorption and micelle formation. Positive adsorption of NaCl was observed in the presence of DeMS and attributed to attractive interaction between the polar head group of DeMS molecule and Na+ or Cl- ions in the adsorbed film and micelle. The results were compared with those of NaCl-octyl methyl sulfoxide and NaCl-decyldimethylphosphine oxide mixtures to elucidate the structure effect of nonionic surfactant on the miscibility. 相似文献
64.
Takahiro Kochi Yoki Nakamura Simeng Ma Kazue Hisaoka-Nakashima Dengli Wang Keyue Liu Hidenori Wake Masahiro Nishibori Masahiro Irifune Norimitsu Morioka 《Molecules (Basel, Switzerland)》2021,26(7)
Persistent pain following orofacial surgery is not uncommon. High mobility group box 1 (HMGB1), an alarmin, is released by peripheral immune cells following nerve injury and could be related to pain associated with trigeminal nerve injury. Distal infraorbital nerve chronic constriction injury (dIoN-CCI) evokes pain-related behaviors including increased facial grooming and hyper-responsiveness to acetone (cutaneous cooling) after dIoN-CCI surgery in mice. In addition, dIoN-CCI mice developed conditioned place preference to mirogabalin, suggesting increased neuropathic pain-related aversion. Treatment of the infraorbital nerve with neutralizing antibody HMGB1 (anti-HMGB1 nAb) before dIoN-CCI prevented both facial grooming and hyper-responsiveness to cooling. Pretreatment with anti-HMGB1 nAb also blocked immune cell activation associated with trigeminal nerve injury including the accumulation of macrophage around the injured IoN and increased microglia activation in the ipsilateral spinal trigeminal nucleus caudalis. The current findings demonstrated that blocking of HMGB1 prior to nerve injury prevents the onset of pain-related behaviors, possibly through blocking the activation of immune cells associated with the nerve injury, both within the CNS and on peripheral nerves. The current findings further suggest that blocking HMGB1 before tissue injury could be a novel strategy to prevent the induction of chronic pain following orofacial surgeries. 相似文献
65.
Y. Morioka 《Solid State Communications》1989,70(12):1127-1129
Raman spectra of polycrystalline YBa2Cu3Ox with various oxygen content x were recorded at 30 K. The intensity of the Cu-O stretching mode at 505 cm-1 depends on the oxygen content significantly. This peak becomes weak as the oxygen content decreases and finally disappears at x=6.05. The last result disagrees with previous Raman studies on the tetragonal phase. Other spectral changes, disappearance of the 115 cm-1 peak and shifts of some peaks, are observed at the oxygen content of ≈6.8. 相似文献
66.
(1,4,7,10-Tetraazacyclododecane) [diamine or (S)-alanine]-cobalt(III) complexes [diamine = ethylenediamine, 2-(aminomethyl)pyridine, (R)-1,2-propanediamine, (R,R)-1,2-diaminocyclohexane, trimethylenediamine and 2-methyl-1,3-diaminopropane] are prepared and characterized spectroscopically. The ligand field transitions occur at lower energies than those of the corresponding tetraamine analogues. Severe distortions caused by the too small size of the cyclic ligand are one of the origins. The distortions also exert influence upon circular dichroism spectra. 相似文献
67.
Yui T Tsuchino T Itoh T Ogawa M Fukushima Y Takagi K 《Langmuir : the ACS journal of surfaces and colloids》2005,21(7):2644-2646
Composite films of a meso-(tetramethylpyridinium)porphyrin (TMPyP) hybrid incorporated in mesoporous silica (MPS) and cast on a methyl viologen (MV2+)/titania nanosheet hybrid were synthesized and a light-induced charge separation between the two could be observed. These composite thin films were able to initiate a one-electron reduction of the MV2+ ions accompanied by the simultaneous decomposition of the TMPyP organic dye within the mesoporous silica channels. 相似文献
68.
A large macrocyclic compound with six para-phenylene rings and six amide moieties, which are alternately secondary and tertiary, was synthesized. In a stepwise synthesis, the final cyclization step was successful because a combination of three tertiary amides, which prefer a cis conformation, and two linear secondary amides would arrange both amino and carboxyl ends close to each other, while various sizes of macrocyclic compounds including the target cyclic trimer were generated in one-pot synthesis where three secondary amide bonds were formed. 相似文献
69.
The preparation of the angular and linear isomers of benzo-fused 1,4-dimethyl-2(1H)-quinolinones 3a–5a and their spectral data including 13C-nmr data are reported. Structural difference among 3a–5a is confirmed from the proximity effect in 1H- and 13C-nmr data and from the uv spectral pattern. 相似文献
70.
Suzuki M Watanabe K Fujiwara S Kurasawa T Wakabayashi T Tsuzuki M Iguchi K Yamori T 《Chemical & pharmaceutical bulletin》2003,51(6):724-727
Two norcarotenoids, 1 and 2, related to peridinin (3) were isolated from the cultured dinoflagellate of the genus Symbiodinium, a symbiont of the Okinawan soft coral Clavularia viridis, which contains in abundance antitumor marine prostanoids such as clavulones. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. These compounds showed significant growth-inhibitory activity in vitro toward cancer cells. Analysis of fatty acids of the dinoflagellate was also carried out, suggesting that the marine prostanoids are produced by the host soft coral itself. 相似文献