Crystal Structure of 〔PrAl(CF_3COO)_2(CF_3CHOO)(C_2H_5)_2(C_4H_8O)_2〕_2

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Synthesis and Antiviral Bioactivity of Novel 2‐Substituted Methlthio‐5‐(4‐Amino‐2‐Methylpyrimidin‐5‐yl)‐1,3,4‐Thiadiazole Derivatives

A series of novel 2‐substituted methlthio‐5‐(4‐amino‐2‐methylpyrimidin‐5‐yl‐)‐1,3,4‐thiadiazole derivatives were synthesized, characterized and evaluated for antiviral activities against tobacco mosaic virus (TMV). The preliminary biological results indicated that most compounds exhibit excellent antiviral activity against TMV in vivo. Among these compounds, compounds 9c , 9i , and 9p displayed the similar curative effect against TMV (EC₅₀ = 287.05–322.47 µg/mL) to that of the commercial agent Ningnanmycin (EC₅₀ = 301.83 µg/mL). In particular, compound 9d demonstrated the best curative effect against TMV (EC₅₀ = 266.21 µg/mL), which was better than that of commercial Ningnanmycin.     

Triticonazole enantiomers: Separation by supercritical fluid chromatography and the effect of the chromatographic conditions

Enantiomeric pairs of triticonazole have been successfully separated by supercritical fluid chromatography coupled with a tris(3,5‐dimethylphenylcarbamoyl) cellulose‐coated chiral stationary phase in this work. The effects of co‐solvent, dissolution solvent, flow rate, backpressure, and column temperature have been studied in detail with respect to retention, selectivity, and resolution of triticonazole. As indicated, the co‐solvents mostly affected the retention factors and resolution, due to the different molecular structure and polarity. In addition, the dissolution solvents, namely, chloromethanes and alcohols, have been also important for enantioseparation because of the different interaction with stationary phase. Higher flow rate and backpressure led to faster elution of the triticonazole molecules, and the change of column temperature showed slight effect on the resolution of triticonazole racemate. Moreover, a comparative separation experiment between supercritical fluid chromatography and high performance liquid chromatography revealed that chiral supercritical fluid chromatography gave the 3.5 times value of R_s/t_R2 than high performance liquid chromatography, which demonstrated that supercritical fluid chromatography had much higher separation efficiency.     

Sorption and Swelling of Poly(D,L-lactic acid) and Poly(lactic-co-glycolic acid) in Supercritical CO2

Summary: The equilibrium sorption and swelling behavior in supercritical CO₂ of poly(D,L-lactic acid) and poly(lactic-co-glycolic acid) has been studied at a temperature of 35 °C and at pressures up to 200 bar. Sorption was measured through a gravimetric technique and swelling by visualization. From these data, the behavior of the different polymers can be compared. In terms of partial molar volume of CO₂ in the polymer matrix, all the polymers exhibit a behavior typical of rubbery systems. The experimental results have been modeled using the Sanchez-Lacombe equation of state, which is able to represent the actual behavior of the polymer-CO₂ systems with reasonable accuracy.     

EVIDENCE FOR INVOLVEMENT OF PHYTOCHROME REGULATION IN MALE STERILITY OF A MUTANT OF Oryza sativa L.

Abstract— A rice mutant ( Oryza sativa L. Nongken 58S) "Hubei photoperiod-sensitive genie male-sterile rice" ( ms mutant) has been found to be male sterile under long day cycles (LD) and fertile in short day cycles (SD). After formation of the secondary rachis-branch primodia the mutant plants under SD were interrupted in the middle of the long night phase (night break) for 10 days with 5 min pulses of red light (R) or far-red light (FR). Rates of normal pollen and seed setting of the mutant treated by R or R → FR → R declined significantly, while the rates after FR or R → FR treatments were similar to those under SD alone. The result of these induction reversion experiments is consistent with the operational criteria for the involvement of photochrome. Wild-type rice ( O. sativa L. Nongken 58) under the same treatment showed no change in fertility. Experiments on the effect of different dark intervals (20 s to 15 min) between R and FR on male sterility of the ms mutant showed that the longer the dark interval, the greater the escape of R induction from FR reversibility. Treatment with SD or LD after formation of pollen mother cells had no influence on fertility of the ms mutant plants treated previously with R or FR night breaks.     

槲皮素修饰的双层脂膜的伏安研究

槲皮素修饰的从层脂膜作为研究抗病毒药物的一种模型体系,用循环伏安法测定了槲皮素在脂膜界面上的氧化还原性质和配位性质。在电位扫描过程中,微量铜离子能催化槲皮素的氧化,当双层脂膜的两侧存在着合适的氧化还原偶时,就会产生跨膜的电子传递。     

电子传输材料噻二唑衍生物的密度泛函研究

用密度泛函B3LYP方法对7种3-(3'-吡啶基)-6-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑分子进行全优化, 所有化合物都是平面分子. 计算了分子的垂直电子亲和势(VEA)、绝热电子亲和势(AEA)、分子内重组能以及绝对硬度等相关能量, 结果显示化合物的HOMO 与LUMO能级可通过连接不同取代基进行调节, 变化幅度为0.346～1.10 eV. 分子内重组能证实3-(4'-氰基-3'-吡啶基)-6-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑是很有前途的电子传输材料, 不同取代基所对应的化合物分子内重组能也不同. 绝对硬度数据与分子内重组能都表明, 化合物E, G难于传输电子. 用TDDFT方法计算了化合物A, B和C的吸收光谱, 与实验值相比, 最大吸收峰的差值在3～10 nm之间.     

An optical resolution of racemic organophosphorous esters by phosphotriesterase-catalyzing hydrolysis

Conclusion  We have shown that PTE chiral recognition is limited to organophosphorous esters having the chiral center on the phosphorous atoms, which is attacked with nucleophile, not having the chiral center on the other atoms of the leaving group. Therefore, PTE can be utilized for the synthesis of their chiral organophosphorous esters.