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The cyclization of an aryllithium tethered to a methylenecycloalkane, generated from 2-(o-bromobenzyl)-1-methylenecycloalkanes 1, 2, and 3 by low-temperature lithium-bromine exchange, has been found to be a kinetically slow but thermodynamically favorable process that proceeds at a convenient rate in an exclusively 5-exo fashion when solutions of the aryllithium in n-heptane-di-n-butyl ether (9:1 v/v) are warmed to 45 degrees C. The cyclization affords stereoisomerically pure cis-fused products (7 and 8) when the methylenecycloalkane is five- or six-membered but it is less stereoselective when the methylenecycloalkane is seven-membered. The ring-closure of the aryllithium derived from 2-(o-bromobenzyl)-1-methylenecyclohexane (2) provides an experimentally convenient route to stereoisomerically pure 4a-substituted cis-hexahydrofluorenes in 60-90% isolated yield. 相似文献
124.
Bisazocalix[4]arenes [N,N′-bis(5-azo-25,26,27-tribenzoyloxy-28-hydroxycalix[4]arene)benzene (1), N,N′-bis(5-azo-25,26,27-tribenzoyloxy-28-hydroxycalix[4]arene)biphenyl (2) and N,N′-bis(5-azo-25,26,27-tribenzoyloxy-28-hydroxycalix[4]arene)-2,2′-dinitro biphenyl (3)] have been synthesized from 25,26,27-tribenzoyloxy-28-hydroxycalix[4]arene by diazocoupling with the corresponding aromatic diamines (p-phenylenediamine, 4,4′-diamino biphenyl and 4,4′-diamino-2,2′-dinitrobiphenyl). Extraction studies of bisazocalix[4]arenes 1, 2, and 3 show no difference in their extraction behavior and selectivity, whereas azocalix[4]arenes are a poor extractant for heavy metal cations. The absorption spectra of the prepared bisazocalix[4]arenes are discussed, both the effect of varying pH and solvent upon the absorption ability of bisazocalix[4]arenes. 相似文献
125.
Haq Nawaz Ahsen Tahir Nauman Ahmed Ubaid U. Fayyaz Tayyeb Mahmood Abdul Jaleel Mandar Gogate Kia Dashtipour Usman Masud Qammer Abbasi 《Entropy (Basel, Switzerland)》2021,23(11)
Global navigation satellite systems have been used for reliable location-based services in outdoor environments. However, satellite-based systems are not suitable for indoor positioning due to low signal power inside buildings and low accuracy of 5 m. Future smart homes demand low-cost, high-accuracy and low-power indoor positioning systems that can provide accuracy of less than 5 m and enable battery operation for mobility and long-term use. We propose and implement an intelligent, highly accurate and low-power indoor positioning system for smart homes leveraging Gaussian Process Regression (GPR) model using information-theoretic gain based on reduction in differential entropy. The system is based on Time Difference of Arrival (TDOA) and uses ultra-low-power radio transceivers working at 434 MHz. The system has been deployed and tested using indoor measurements for two-dimensional (2D) positioning. In addition, the proposed system provides dual functionality with the same wireless links used for receiving telemetry data, with configurable data rates of up to 600 Kbauds. The implemented system integrates the time difference pulses obtained from the differential circuitry to determine the radio frequency (RF) transmitter node positions. The implemented system provides a high positioning accuracy of 0.68 m and 1.08 m for outdoor and indoor localization, respectively, when using GPR machine learning models, and provides telemetry data reception of 250 Kbauds. The system enables low-power battery operation with consumption of <200 mW power with ultra-low-power CC1101 radio transceivers and additional circuits with a differential amplifier. The proposed system provides low-cost, low-power and high-accuracy indoor localization and is an essential element of public well-being in future smart homes. 相似文献
126.
Hee-Sung Chae Olivia Dale Tahir Maqbool Mir Bharathi Avula Jianping Zhao Ikhlas A. Khan Shabana I. Khan 《Molecules (Basel, Switzerland)》2022,27(3)
Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ), liver X receptor (LXR), glucose uptake, and lipid accumulation (adipogenesis). Activation of PPARα, PPARγ and LXR was determined in hepatic (HepG2) cells by reporter gene assays. Glucose uptake was determined in differentiated muscle (C2C12) cells using 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose). Adipogenesis was determined in adipocytes (3T3-L1 cells) by Oil red O staining. At a concentration of 50 µg/mL, AF caused 12.2-fold activation of PPARα and 5.7-fold activation of PPARγ, while the activation of LXR was only 1.7-fold. AF inhibited (28%) the adipogenic effect induced by rosiglitazone in adipocytes and increased glucose uptake (32.8%) in muscle cells at 50 μg/mL. It was concluded that AF acted as a PPARα/γ dual agonist without the undesired effect of adipogenesis and exhibited the property of enhancing glucose uptake. This is the first report to reveal the PPARα/γ dual agonistic action and glucose uptake enhancing property of AF along with its antiadipogenic effect, indicating its potential in ameliorating the symptoms of metabolic syndrome. 相似文献
127.
Madeeha Shahzad Lodhi Fatima Khalid Muhammad Tahir Khan Zahoor Qadir Samra Shabbir Muhammad Yu-Juan Zhang Kejie Mou 《Molecules (Basel, Switzerland)》2022,27(1)
Therapeutic effects of anticancer medicines can be improved by targeting the specific receptors on cancer cells. Folate receptor (FR) targeting with antibody (Ab) is an effective tool to deliver anticancer drugs to the cancer cell. In this research project, a novel formulation of targeting drug delivery was designed, and its anticancer effects were analyzed. Folic acid-conjugated magnetic nanoparticles (MNPs) were used for the purification of folate receptors through a novel magnetic affinity purification method. Antibodies against the folate receptors and methotrexate (MTX) were developed and characterized with enzyme-linked immunosorbent assay and Western blot. Targeting nanomedicines (MNP-MTX-FR Ab) were synthesized by engineering the MNP with methotrexate and anti-folate receptor antibody (anti-FR Ab). The cytotoxicity of nanomedicines on HeLa cells was analyzed by calculating the % age cell viability. A fluorescent study was performed with HeLa cells and tumor tissue sections to analyze the binding efficacy and intracellular tracking of synthesized nanomedicines. MNP-MTX-FR Ab demonstrated good cytotoxicity along all the nanocomposites, which confirms that the antibody-coated medicine possesses the potential affinity to destroy cancer cells in the targeted drug delivery process. Immunohistochemical approaches and fluorescent study further confirmed their uptake by FRs on the tumor cells’ surface in antibody-mediated endocytosis. The current approach is a useful addition to targeted drug delivery for better management of cancer therapy along with immunotherapy in the future. 相似文献
128.
129.
Amita Gupta Alexei Yu Ganin Parmanand Sharma Vikrant Agnihotri LM Belova KV Rao Mikhail E Kozlov AA Zakhidov RH Baughman 《Pramana》2002,58(5-6):1051-1059
We present studies of novel nanocomposites of BiNi impregnated into the structure of opals as well as inverse opals. Atomic force microscopy and high resolution elemental analyses show
a highly ordered structure and uniform distribution of the BiNi filler in the matrix. These BiNi-based nanocomposites are
found to exhibit distinct ferromagnetic-like ordering with transition temperature of about 675 K. As far as we know there
exists no report in literature on any BiNi compound which is magnetic. 相似文献
130.
Tahir MN Théato P Müller WE Schröder HC Borejko A Faiss S Janshoff A Huth J Tremel W 《Chemical communications (Cambridge, England)》2005,(44):5533-5535
Silicatein immobilised on self-assembled polymer layers using a histidine-tag chelating anchor group retains its hydrolytical activity for the formation of biosilica, and catalyses the formation of layered arrangements of biotitania and biozirconia. 相似文献