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81.
Ali Deeb 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):637-650
AbstractThis review describes the synthesis and reactions of 5-aminothieno[2,3-c]pyridazine-6-carbonitriles as a building blocks for the synthesis of polyfunctionalized heterocyclic compounds. The antimicrobial activity of some compounds are discussed. 相似文献
82.
Hamid Hadi-Alijanvand Ali A. Moosavi-Movahedi Bahram Goliaei 《Journal of the Iranian Chemical Society》2013,10(5):907-914
Prolyl hydroxylase domain 2 containing protein (PHD2) is a central protein in regulation of cellular response to hypoxia. This protein controls the responses of cell to oxygen level via the regulation of hypoxia inducible factor (HIF) stability. HIF induces the expression of many genes, especially ones orchestrate angiogenesis. There are some reports that mentioned in some tumor types the level of HIF is high in spite of the presence of wild-type PHD2 and normoxic environment. Therefore, the possibility of PHD2 misfolding in some cancer cells arises. Studying such important protein unfolding pathway is insightful for possible therapeutic approaches. In this study, the unfolding pathway of PHD2 illustrates utilizing molecular dynamics simulation of protein thermal denaturation. Based on current study results, we represent the possible mechanisms of PHD2 unfolding in detail. The possible intermediates of PHD2 thermal unfolding are characterized, and the most venomous state of its unfolding pathway is introduced. 相似文献
83.
Various types of trimethylsilyl and tert-butyldimethylsilyl ethers of primary and secondary benzylic alcohols could be selectively converted to their corresponding carbonyl compounds with MnO2 in the presence of AlCl3 in good to excellent yields. 相似文献
84.
The complexation equilibria of Fe(III) with two buffer families, which are ubiquitous in biological system studies, were studied by potentiometric measurements at a constant ionic strength of I = 0.1 mol·dm?3 NaNO3 in aqueous solutions at 298.15 K. The members of TRIS family are tris(hydroxymethyl)aminomethane (TRIS), N-[tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid (TES), N-[tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid (TAPS), N-[tris(hydroxymethyl)methyl]-3-amino-2-hydroxypropanesulfonic acid (TAPSO), and N-tris(hydroxymethyl)methyl-4-aminobutanesulfonic acid (TABS) buffers. The members of morpholine family are 4-morpholineethanesulfonic acid (MES), 4-morpholinepropanesulfonic acid (MOPS), 3-morpholino-2-hydroxypropanesulfonic acid (MOPSO), and 4-(N-morpholino) butanesulfonic acid (MOBS) buffers. The overall stability constants were determined from pH-metric data using the least-squares curve-fitting program HYPERQUAD 2008. Based on the best-fit results, the species formed at equilibrium are ML, ML2, ML2H?1, and ML3 in the systems with TRIS family buffers. The complex species ML, ML2, ML2H?1, and MLH?1 are formed in the MOPSO-containing system, while ML, ML2, and ML2H?1 are formed in the systems with MES, MOPS, and MOBS. The stabilities of the complexes fall in the order TABS > TRIS > TAPS > TAPSO > TES and MOBS > MOPS > MOPSO > MES for the TRIS family and morpholine families, respectively. 相似文献
85.
Batch equilibrium studies were conducted at 20 ± 0.5 °C with indigenously synthesized spherical resorcinol–formaldehyde resin beads, using radioanalytical technique, to determine their capacity for sorption of cesium ions from alkaline medium. Equilibrium isotherm studies were carried out, by varying the initial concentrations of cesium from 0.1 to 50 mM. The liquid-to-solid phase ratio of ~100 ml:1 g was maintained for all the sorption experiments. The equilibrium data were fitted to Langmuir and Freundlich isotherm models. It was observed that Freundlich isotherm explains sorption process nicely. The effect of resin size on percentage cesium ion uptake was also investigated, and 20–40 mesh size was found to be the optimum particle size. The cesium sorption capacity of the beads was determined to be ~238 mg/g. The kinetics of the sorption was studied at different initial cesium ion concentrations, and the kinetics data were fitted into various kinetics models. The kinetics of the cesium ion sorption was found to be pseudo second-order. The mechanistic steps involved were found to be complex, consisting of both film diffusion and intraparticle diffusion with film diffusion as the rate limiting step. 相似文献
86.
Keng Yoon Yeong Mohamed Ashraf Ali Chee Wei Ang Soo Choon Tan Hasnah Osman 《Tetrahedron letters》2014
A facile method to synthesize various 1,2-disubstituted benzimidazoles is developed. It is suggested that formation of a Meisenheimer adduct between the substrate, amine, and solvent aids the N-arylation process. The generality of the protocol is demonstrated by the efficient reactions involving numerous substituents ranging from electron-withdrawing groups to electron-donating groups. 相似文献
87.
Syam Sundar L. Misganaw A. H. Singh Manoj K. Sousa António C. M. Ali Hafiz Muhammad 《Journal of Thermal Analysis and Calorimetry》2021,143(2):959-972
Journal of Thermal Analysis and Calorimetry - In the present study, the thermal efficiency, convective heat transfer and friction factor analysis are investigated for a flat plate solar collector... 相似文献
88.
89.
Surface tensions of some Pb-free solder systems such as Ag–Bi–Sn with cross-sections Ag/Bi = 1/1, Ag/Bi = 1/2, Ag/Bi = 2/1, In–Sn–Zn with cross-sections Sn/In = 1/1, Sn/In = 1/3 and (Ag7Cu3)100?x Snx with cross-section Ag/Cu = 7/3 are calculated from the sub-binary surface tension data using the models, such as the Muggianu, Kohler, Toop models, Butler’s equation and Chou’s General Solution Model (GSM) at 873, 923 and 1073 K, respectively. The surface tension of In–Sn–Zn increases wavily with increasing amount of Zn and it is found that the best models are the GSM for both cross-sections in question while GSM becomes the best model for (Ag7Cu3)100?x Snx alloy in the whole experimental range. Moreover, the surface tension of (Ag7Cu3)100?x Snx decreases slightly with increasing amount of Sn. The Muggianu, Butler and Butler models are determined as the best models for the cross-sections in the order given above for entire measurement range, respectively, and the surface tension of Ag–Bi–Sn decreases slightly with an increasing amount of Bi and Ag but increases with increasing Sn in liquid alloys. 相似文献
90.
Benzoyl peroxide (BPO) is primarily used in the treatment of mild to moderate acne. However, its application is associated with skin irritation. It has been shown that encapsulation and controlled release of BPO could reduce the side effect while also reducing percutaneous absorption when administered to the skin. The aim of the present investigation was to design and formulate an appropriate encapsulated form of BPO, using microsponge technology, and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Benzoyl peroxide particles were prepared using an emulsion solvent diffusion method by adding an organic internal phase containing benzoyl peroxide, ethyl cellulose and dichloromethane into a stirred aqueous phase containing polyvinyl alcohol (PVA). Different concentrations of BPO microsponges were incorporated in lotion formulations and the drug release from these formulations were studied. The SEM micrographs of the BPO microsponges enabled measurement of their size and showed that they were spherical and porous. Results showed that the morphology and particle size of microsponges were affected by drug:polymer ratio, stirring rate and the amount of emulsifier used. The results obtained also showed that an increase in the ratio of drug:polymer resulted in a reduction in the release rate of BPO from the microsponges. The release data showed that the highest and the lowest release rates were obtained from lotions containing plain BPO particles and BPO microsponges with the drug:polymer ratio of 13:1, respectively. The kinetics of release study showed that the release data followed Peppas model and the main mechanism of drug release from BPO microsponges was diffusion. 相似文献