全文获取类型
收费全文 | 172篇 |
免费 | 4篇 |
国内免费 | 3篇 |
专业分类
化学 | 138篇 |
力学 | 2篇 |
数学 | 4篇 |
物理学 | 35篇 |
出版年
2024年 | 3篇 |
2023年 | 3篇 |
2022年 | 20篇 |
2021年 | 16篇 |
2020年 | 8篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2017年 | 8篇 |
2016年 | 5篇 |
2014年 | 10篇 |
2013年 | 15篇 |
2012年 | 8篇 |
2011年 | 14篇 |
2010年 | 8篇 |
2009年 | 5篇 |
2008年 | 4篇 |
2007年 | 1篇 |
2006年 | 2篇 |
2005年 | 4篇 |
2004年 | 11篇 |
2003年 | 6篇 |
2001年 | 3篇 |
1999年 | 2篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有179条查询结果,搜索用时 31 毫秒
161.
The present study was carried out to examine the mechanisms of the synergistic interaction of PAF and A23187 mediated platelet aggregation. We found that platelet aggregation mediated by subthreshold concentrations of PAF (5 nM) and A23187 (1 mM) was inhibited by PAF receptor blocker (WEB 2086, IC50 = 0.65 mM) and calcium channel blockers, diltiazem (IC50 = 13 mM) and verapamil (IC50 = 18 mM). Pretreatment of platelets with PAF and A23187 induced rise in intracellular calcium and this effect was also blocked by verapamil. While examining the role of the down stream signaling pathways, we found that platelet aggregation induced by the co-addition of PAF and A23187 was also inhibited by low concentrations of phospholipase C (PLC) inhibitor (U73122; IC50 = 10 mM), a cyclooxygenase inhibitor (indomethacin; IC50 = 0.2 mM) and inhibitor of TLCK, herbimycin A with IC50 value of 5 mM. The effect was also inhibited by a specific TXA2 receptor antagonist, SQ 29548 with very low IC50 value of 0.05 mM. However, the inhibitors of MAP kinase, PD98059 and protein kinase C, chelerythrine had no effect on PAF and A23187-induced platelet aggregation. These data suggest that the synergism between PAF and A23187 in platelet aggregation involves activation of thromboxane and tyrosine kinase pathways. 相似文献
162.
A rapid, simple and accurate spectrophotometric method is developed for the determination of ondansetron hydrochloride in pure and tablet formulations. The method depends on the charge‐transfer complexation between ondansetron base as n‐electron donor with chloranil as π‐acceptor to give a colored complex, which absorbs maximally at 470 nm. Beer's law is obeyed in the concentration ranges 70–980 μg mL?1 with molar absorptivity of 4.47 × 102 L mole?1 cm?1. The proposed method is precise, accurate and specific for the quantitative determination of drug in bulk and tablet formulations. 相似文献
163.
Preparation of novel,moisture-stable,Lewis-acidic ionic liquids containing quaternary ammonium salts with functional side chains 总被引:1,自引:0,他引:1
Abbott AP Capper G Davies DL Munro HL Rasheed RK Tambyrajah V 《Chemical communications (Cambridge, England)》2001,(19):2010-2011
A range of novel, moisture-stable, Lewis-acidic ionic liquids has been prepared by mixing appropriate molar ratios of MCl2 (M = Zn and/or Sn) and quaternary ammonium salts of formula [Me3NC2H4Y]Cl (Y = OH, Cl, OC(O)Me, OC(O)Ph); the influence of substituent Y and metal M on the physical properties of the melts has been investigated. 相似文献
164.
Rasheed Ahmad Khera Rasheed Ahmad Alexander Villinger Peter Langer 《Journal of fluorine chemistry》2010,131(9):892-897
The reaction of the dianion of 1,1,1-trifluoro-pentane-2,4-dione with aldehydes and subsequent addition of hydrochloric acid afforded 2,3-dihydro-6-trifluoromethyl-pyran-4-ones. The reaction of the dianion of acetylacetone with fluorinated benzaldehydes gave the corresponding fluorinated 2-aryl-2,3-dihydro-6-methyl-pyran-4-ones. All reactions proceeded in very good yield and with very good regioselectivity. 相似文献
165.
We reported the first mussel-inspired alternating copolymer with a high amount of catechol groups(50% molar ratio) through a facile epoxy-amino click reaction between 9,9-bis(4-(2-glycidyloxyethyl)phenyl fluorene(BGEPF) and dopamine(DA).The obtained copolymers were used to prepare carbon/nitrogen-doped α-Fe_2O_3 nanoparticles through self-assembly,coordination and calcination,which displayed excellent electrochemical performance as anode materials for Li-ion batteries. 相似文献
166.
Nawaz Rahat Rasheed Tahir Iqbal Taniya Bilal Muhammad Majeed Saadat 《Monatshefte für Chemie / Chemical Monthly》2020,151(4):505-510
Monatshefte für Chemie - Chemical Monthly - Herein, a carbon paste electrode was modified with 2,4-dinitrophenylhydrazine (2,4-DNPHMCPE), for the first time, to sense the three amino acids... 相似文献
167.
Suzuki-Miyaura reactions of 2,3,4,5-tetrabromofuran allow a convenient and site-selective synthesis of mono-, di- and tetraarylfurans which are not readily available by other methods. 相似文献
168.
Kamdem RS Wafo P Yousuf S Ali Z Adhikari A Rasheed S Khan IA Ngadjui BT Fun HK Choudhary MI 《Organic letters》2011,13(20):5492-5495
Canarene (1), a triterpene with an unprecedented carbon backbone, was isolated from Canarium schweinfurthii . It is the first member of a new class of triterpenoids, for which the name "canarane' is proposed. 1 showed weak α-glucosidase inhibitory activity, and its structure was unambiguously deduced by single-crystal X-ray diffraction. 相似文献
169.
A. Rasheed Khan Fahim Uddin Rehana Saeed Mahjabeen Mukhtar 《Frontiers of Chemistry in China》2011,6(2):113-119
The effects of CuCl2 and ZnCl2 on the viscosity in aqueous ethanol mixtures (10%–50% v/v) were studied in the concentration range 1.0×10−2–8.0×10−2 mol·dm−3 at different temperatures. It was found that the viscosities increased with an increase in the concentration of the salts
and percent composition of ethanol content, whereas it decreased with an increase in temperature. Ion-ion and ion-solvent
interactions are determined with the help of A- and B-coefficients of Jones-Dole equation. The values of A- and B-coefficients are irregular and increase with a rise in temperature and also with an increase in ethanol contents for both
salts. Negative values of B-coefficients show that ion solvent interactions is comparatively small and suggest that CuCl2 and ZnCl2 behave as structure breakers in aqueous ethanol mixtures. Thermodynamic parameters like the energy of activation (E
η
) and change in entropy of activation (ΔS*) were also evaluated which confirm the structure breaker behavior of salts in aqueous ethanol mixtures. 相似文献
170.
Khan AN Fatima I Khaliq UA Malik A Miana GA Qureshi ZU Rasheed H 《Molecules (Basel, Switzerland)》2011,16(3):2053-2064
New naturally occurring nitrogenous compounds 1 and 2, along with a new dimeric lignan glucoside 3, have been isolated from the ethyl acetate soluble fraction of Centaurea iberica. Their structures have been elucidated through spectroscopic techniques. All the isolated compounds showed significant platelet aggregation inhibition. 相似文献